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At what age do sunburn episodes play a crucial role for the development of malignant melanoma

The age relationship between sunburns and malignant melanoma was investigated in a population-based, matched, case-control study from the South Swedish Health Care Region (the highest risk area for melanoma in Sweden). Between 1988 and 1990, a total of 400 patients with a first diagnosis of malignant melanoma and 640 healthy controls aged 15-75 years answered a comprehensive questionnaire includin

The prognosis of breast cancer in males a report of 335 cases

Background. Because of the relative rarity of breast cancer in males, data have not been sufficient to support a definitive analysis of pertinent prognostic factors. Remarkably, no studies of male patients with breast cancer have presented survival information based on the number of histologically positive axillary nodes, the most sensitive single indicator of prognosis in women with breast cancer

Metabolism of estrone sulfate by normal breast tissue : Influence of menopausal status and oral contraceptives

The metabolism of [ 3 H]estrone sulfate ([ 3 H]E 1 S) was studied in normal breast tissue from 10 premenopausal women without oral contraceptives (OC), in 12 OC users and in 9 untreated postmenopausal women. [ 3 H]E 1 S was converted into estrone ([ 3 H]E 1 ) and estradiol-17β ([ 3 H]E 2 ) by tissue samples from all three groups of women, with only minor formation of other unconjugated compounds.

Socialt arbete och pappersgöra : Mellan klient och digitala dokument

Standardiserade dokument och digitala formulär omgärdar socionomens arbete. I boken Socialt arbete och pappersgöra tar författarna med oss till socialtjänstkontoren och undersöker hur det går till när socialt arbete dokumenteras. Hur påverkar dokumentationen mötet med klienten? Vilka blir konsekvenserna? Och varför? Bokens viktigaste budskap är att till synes neutrala dokumentationssystem påtaglig

Rock, paper, scissors : Lessons from the steel industry - Should paper listen?

The US paper industry should understand competent management and continuous innovation in a competitive environment in order to ensure the proper growth of the industry. It is suggested that investment in new technology and processes ensures the benefits to companies and the government policies is not the optimal solution to improve the industry. The United States is although a powerful nation but

Chloroperoxidase catalysed oxidation of benzyl alcohol using tert-butyl hydroperoxide oxidant in organic media

The quantitative oxidation of benzyl alcohol to benzaldehyde using the enzyme chloroperoxidase (CPO) from Caldariomyces fumago as catalyst and tert-butyl hydroperoxide (t-BuOOH) as a cosubstrate for the enzyme, in organic solvent is demonstrated. The enzymatic transformation of primary alcohols to aldehydes has not previously been shown in predominantly organic solvent using CPO, and in aqueous me

papiNet - A vehicle for supply chain standardization and integratior

The Paper and Plastics Education and Research Insitute at the University of North Florida and NPTA have taken an initiative to adopt and implement the papiNet standards for supply chain standardization and integration. papiNet can be described as a global standard for the paper and forest industries. The companies, which want to adopt papiNet, are required to follow the standards developed by the

From function to process : A logistics-based framework for transforming Tetra Pak business support

This article describes a logistics-based framework for organizational change of service organizations. This framework is based on the key concepts of modern logistics: systems thinking for a holistic approach to business; process orientation for structure of the organization; and process management for continuous change and improvement. The development of logistics as a research and practitioner d

Interesterification of phosphatidylcholine with lipases in organic media

Lipases were investigated with respect to their ability to catalyse the incorporation of fatty acids into phosphatidylcholine (PC) by interesterification reactions. The enzymes were dried onto solid support materials and the conversions were carried out in water-saturated toluene. Three lipases (two fungal and one plant enzyme) had the desired activity; immobilized lipase from Mucor miehei (Lipozy

Optimization of galactooligosaccharide production from lactose using β-glycosidases from hyperthermophiles

The maximal production of galactooligosaccharides (GOS) from lactose by (β-glycosidases from the hyperthermophilic archaea, Sulfolobus solfataricus (LacS) (derived from lacS gene) and Pyrococcus furiosus (CelB) (derived from celB gene) was optimized. The performance of these enzymes under extreme reaction conditions, temperatures up to 95°C and lactose concentrations up to 90% (w/v), were studied.

Immobilisation of lipases by adsorption and deposition : High protein loading gives lower water activity optimum

Two different immobilisation techniques for lipases were investigated: adsorption on to Accurel EP-100 and deposition on to Celite. The specific activities were in the same order of magnitude, 2.9 (μmol min -1 mg protein) when Celite was used as support and 2.3 (μmol min -1 mg -1 protein) when Accurel EP-100 was used as support, even if the amount of lipase loaded differed by 2 orders of magnitude

Reaction medium engineering in enzymatic peptide fragment condensation : Synthesis of eledoisin and LH-RH

The influence of different reaction systems on α-chymotrypsin-catalyzed synthesis of eledoisin and LH-RH peptides from (7+4) and (5+5) fragments was investigated. The peptide yield was determined in the following systems: buffered aqueous media, frozen solutions, organic media, and cosolvent mixtures. The experimental set up was tailored to allow the screening of an array of conditions with minimu

Physical characterization of porous materials and correlation with the activity of immobilized enzyme in organic medium

A series of commonly used porous supports was characterized by determination of particle size distribution, porosity, surface area (total and distributions with pore diameters) and skeletal density. The performance of immobilized α-chymotrypsin catalyzed dipeptide synthesis in an acetonitrile medium was correlated with these physical properties.At high enzyme loading, when internal mass transfer l

Does the bile salt stimulated lipase of human milk have a role in the use of the milk long-chain polyunsaturated fatty acids?

Long-chain polyunsaturated (LCP) fatty acids derived from linoleic (18:2 n-6) and alpha-linolenic (18:3 n-3) acids are considered essential nutrients in preterm infants. The efficiency by which such fatty acids are released as absorbable products from triacylglycerol was explored in vitro using rat chylomicron triacylglycerol as substrate. When incubated with purified human pancreatic colipase-depLong-chain polyunsaturated (LCP) fatty acids derived from linoleic (18:2 n-6) and alpha-linolenic (18:3 n-3) acids are considered essential nutrients in preterm infants. The efficiency by which such fatty acids are released as absorbable products from triacylglycerol was explored in vitro using rat chylomicron triacylglycerol as substrate. When incubated with purified human pancreatic colipase-dep

Drell-Yan, ZZ, W+W- production in SM & ADD model to NLO+PS accuracy at the LHC

In this paper, we present the next-to-leading order QCD corrections for di-lepton, di-electroweak boson (ZZ, W+W-) production in both the SM and the ADD model, matched to the HERWIG parton shower using the aMC@NLO framework. A selection of results at the 8 TeV LHC, which exhibit deviations from the SM as a result of the large extra-dimension scenario, are presented.