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Cardiac Transplantation and Organ Preservation

This chapter will deal with the advances and the innovative paradigms leading to reengineering the preservation of the myocardium and the potential of new upcoming reconditioning strategies to reduce BDD organ shortage and move toward DCD donation.

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Die Folgen des Klimawandels für die Gesundheit sind bereits heute spürbar und als zunehmende Bedrohung für die Gesundheit in Österreich einzustufen. Die stärksten Gesundheitsfolgen mit breiter Wirkung sind durch Hitze zu erwarten. Veränderungen in Ökosystemen begünstigen zudem das Auftreten von Pollenallergien und durch Vektoren übertragene Infektionskrankheiten. Mit vermehrten Gesundheitsfolgen i

If Marc is Suzanne’s father, does it follow that Suzanne is Marc’s child? An experimental philosophy study in reproductive ethics

In this paper, we report the results from an experimental reproductive ethics study exploring questions about reproduction and parenthood. The main finding in our study is that, while we may assume that everyone understands these concepts and their relationship in the same way, this assumption may be unwarranted. For example, we may assume that if ‘x is y’s father’, it follows that ‘y is x’s child

International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024

The "International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024" updates and replaces the "Listing Criteria for Heart Transplantation: International Society for Heart and Lung Transplantation Guidelines for the Care of Cardiac Transplant Candidates-2006" and the "2016 International Society for Heart Lung Transplantation Lis

Phosphorylated tau in cerebrospinal fluid-derived extracellular vesicles in Alzheimer’s disease.

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ) peptides and phosphorylated tau (P-tau) proteins in the brain, leading to cognitive decline and memory impairment. Despite extensive research, the exact mechanisms of AD pathogenesis remain elusive, and reliable biomarkers for early diagnosis and disease monitoring are still ne

Carbon isotope values of hazelnut shells: a new proxy for canopy density

Hazel (Corylus avellana) has been abundant in the vegetation of northern and central Europe since the early Holocene and has provided food and materials for humans ever since. Here we use stable carbon isotope (δ13C) values of hazelnut shells to infer woodland openness based on the premise of the “canopy effect”. It is well established that plants growing in dense, shaded forests have lower carbon

Measurement of ZZ production cross-sections in the four-lepton final state in pp collisions at s=13.6TeV with the ATLAS experiment

This paper reports cross-section measurements of ZZ production in pp collisions at s=13.6TeV at the Large Hadron Collider. The data were collected by the ATLAS detector in 2022, and correspond to an integrated luminosity of 29 fb−1. Events in the ZZ→4ℓ (ℓ=e, μ) final states are selected and used to measure the inclusive and differential cross-sections in a fiducial region defined close to the anal

Search for high-mass resonances in final states with a Formula Presented-lepton and missing transverse momentum with the ATLAS detector

A search for high-mass resonances decaying into a Formula Presented-lepton and a neutrino using proton-proton collisions at a center-of-mass energy of Formula Presented is presented. The full run 2 data sample corresponding to an integrated luminosity of Formula Presented recorded by the ATLAS experiment in the years 2015-2018 is analyzed. The Formula Presented-lepton is reconstructed in its hadro

Nulliparous women's lived experiences of the prolonged passive stage of labour : A thematic analysis based on descriptive phenomenology

Introduction: Prolonged progress can occur in the first and second stages of labour and may contribute to a negative birth experience. However, previous studies have mainly focused on quantitative aspects or overall birth experience, and little is known about women's experiences of a prolonged passive second stage. Objective: To describe the lived experiences of a prolonged passive second stage of

Urbanisation-associated shifts in the avian metabolome within the annual cycle

While organisms have evolved to cope with predictable changes in the environment, the rapid rate of current global change presents numerous novel and unpredictable stressors to which organisms have had less time to adapt. To persist in the urban environment, organisms must modify their physiology, morphology and behaviour accordingly. Metabolomics offers great potential for characterising organism

Multispecies synbiotics alleviate dextran sulfate sodium (DSS)-induced colitis : Effects on clinical scores, intestinal pathology, and plasma biomarkers in male and female mice

Background: Inflammatory bowel disease (IBD) is characterized by recurrent inflammation of the gastrointestinal tract and has been linked to an imbalance in gut bacteria. Synbiotics, which combine probiotics and prebiotics, are emerging as potential IBD treatments. Aim: To examine the effects of four synbiotic formulations on intestinal inflammation and peripheral biomarkers in a rodent IBD model

Are we using more sugar substitutes? Wastewater analysis reveals differences and rising trends in artificial sweetener usage in Swedish urban catchments

The market for artificial sweeteners as substitutes for conventional sugar (sucrose) is growing, despite potential health risks associated with their intake. Estimating population usage of artificial sweeteners is therefore crucial, and wastewater analysis can serve as a complement to existing methods. This study evaluated spatial and temporal usage of artificial sweeteners in five Swedish communi

Study of Z→llγ decays at s = 8 TeV with the ATLAS detector

This paper presents a study of Z→llγ decays with the ATLAS detector at the Large Hadron Collider. The analysis uses a proton–proton data sample corresponding to an integrated luminosity of 20.2 fb-1 collected at a centre-of-mass energy s = 8 TeV. Integrated fiducial cross-sections together with normalised differential fiducial cross-sections, sensitive to the kinematics of final-state QED radiatio

In-depth proteomic analysis and structural modelling of protein-protein interactions identify known and novel molecular binding partners for EMP3 in erythroid cells

Background: The absence of Epithelial Membrane Protein 3 (EMP3) on red blood cells (RBCs) underlies the MAM-negative (MAM−) phenotype. EMP3 is a ubiquitous protein found at low levels in most tissues but with higher expression in hematopoietic cells. Low levels of CD44 are a signature of MAM− RBCs due its proposed physical interaction with EMP3, indicating that EMP3 stabilises CD44 in the membrane

Search for Nearly Mass-Degenerate Higgsinos Using Low-Momentum Mildly Displaced Tracks in pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector

Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is O(1 GeV). This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse imp

Variability of polygenic prediction for body mass index in Africa

Background: Polygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent. Studies to understand the factors that affect PRS variability within Africa are required. Methods: Using the first multi-ancestry genome-wide associa

Validation of the Health Assessment Tool (HAT) based on four aging cohorts from the Swedish National study on Aging and Care

Background: As global aging accelerates, routinely assessing the functional status and morbidity burden of older patients becomes paramount. The aim of this study is to assess the validity of the comprehensive clinical and functional Health Assessment Tool (HAT) based on four cohorts of older adults (60 + years) from the Swedish National study on Aging and Care (SNAC) spanning urban, suburban, and

Impact of final design on daylight provision

Daylight analysis informs design decisions in architectural spaces, yet materials, colours, and furnishings - often chosen later - can significantly impact indoor daylighting. This study assessed these effects in a typical open-plan office in Copenhagen using parametric simulations with Radiance through Honeybee in Grasshopper, complemented by a sensitivity analysis following the Morris method. Va