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Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset

HLA-associated relative risks of type 1 (insulin-dependent) diabetes mellitus were analysed in population-based Swedish patients and controls aged 0-34 years. The age dependence of HLA-associated relative risks was assessed by likelihood ratio tests of regression parameters in separate logistic regression models for each HLA category. The analyses demonstrated an attenuation with increasing age at

Exploring sensory perception, appraisal and concern: An approach to support design activity

The fundamental first stage of product interaction is through sensory perception, which generates cognitive and affective experiences. Product perception through sensory feedback is a major component in the end user product appraisal that precedes the elicitation of product emotion. Sensory evaluation is connected to a set of concepts including appraisal, concern and goal oriented objective. The i

Association of Arsenic Exposure with Whole Blood DNA Methylation : An Epigenome-Wide Study of Bangladeshi Adults

BACKGROUND: Arsenic exposure affects [Formula: see text] people worldwide, including [Formula: see text] in Bangladesh. Arsenic exposure increases the risk of cancer and other chronic diseases, and one potential mechanism of arsenic toxicity is epigenetic dysregulation. OBJECTIVE: We assessed associations between arsenic exposure and genome-wide DNA methylation measured at baseline among 396 Bangl

Age governs gender-dependent islet cell autoreactivity and predicts the clinical course in childhood IDDM

Most IDDM patients temporarily restore some of their beta-cell function following the initiation of insulin therapy. The aim of this study was to analyse the influence of age, gender, metabolic state at diagnosis and presence of autoantibodies (GAD65 antibodies and ICA) on the duration of the clinical partial remission. In total, 149 consecutively diagnosed IDDM children, 0-16 y old (70F, 79M, mea

Different HLA-DR-DQ haplotypes are associated with cervical intraepithelial neoplasia among human papillomavirus type-16 seropositive and seronegative Swedish women

To analyze whether HLA may be a determinant of the risk of developing cervical cancer precursor lesions, the association between HLA and cervical neoplasia among HPV16-seropositive and -negative subjects was determined in a population-based cohort in the Vasterbotten county of Northern Sweden. HLA genotyping of DR and DQ was done by PCR in 74 patients and 164 healthy controls matched for age, sex

Intraluminal duodenal diverticulum causing pancreatitis in a patient with a polysplenia syndrome

A 19-year-old female had recurrent bouts of pancreatitis. At endoscopy a mucosa-covered mass lesion was seen in the duodenum. A double-contrast examination of the stomach and duodenum showed an intraluminal duodenal diverticulum (IDD). Also an inversed abdominal situs and a midgut malrotation were noted. Computed tomography revealed evidence of a polysplenia syndrome. Although this syndrome is ass

RECONCILING the ORBITAL and PHYSICAL PROPERTIES of the MARTIAN MOONS

The origin of Phobos and Deimos is still an open question. Currently, none of the three proposed scenarios for their origin (intact capture of two distinct outer solar system small bodies, co-accretion with Mars, and accretion within an impact-generated disk) are able to reconcile their orbital and physical properties. Here we investigate the expected mineralogical composition and size of the grai

Electron and photon energy calibration with the ATLAS detector using 2015-2016 LHC proton-proton collision data

This paper presents the electron and photon energy calibration obtained with the ATLAS detector using about 36 fb -1 of LHC proton-proton collision data recorded at s=13 TeV in 2015 and 2016. The different calibration steps applied to the data and the optimization of the reconstruction of electron and photon energies are discussed. The absolute energy scale is set using a large sample of Z boson d

Sequentially loop-generated quark and lepton mass hierarchies in an extended Inert Higgs Doublet model

Extended scalar and fermion sectors offer new opportunities for generating the observed strong hierarchies in the fermion mass and mixing patterns of the Standard Model (SM). In this work, we elaborate on the prospects of a particular extension of the Inert Higgs doublet model where the SM hierarchies are generated sequentially by radiative virtual corrections in a fully renormalisable way, i.e. w

HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin dependent diabetes mellitus

Autoantibodies to glutamic acid decarboxylase (GAD65Ab) are common in both caucasian and Japanese patients with insulin-dependent diabetes mellitus (type 1), while the type 1-associated HLA haplotypes differ. In the present study, we analyzed GAD65Ab in relation to HLA-DQ and -DR alleles in Japanese type 1 patients. GAD65Ab were found in 58% short-duration (less than 5 years) type 1, 23% long-dura

Association between HLA and islet cell antibodies in diabetic patients with a mitochondrial DNA mutation at base pair 3243

Islet cell antibodies (ICA), autoantibodies to glutamic acid decarboxylase (GAD) and HLA genotypes were examined in 31 patients with diabetes and a mitochondria! gene mutation located at base pair 3243 (mtDNA 3243 mutation). ICA was detected in 42 % (13/31) of these patients compared to 0 of 90 among healthy control subjects. The ICA showed a "non-restricted" pattern of staining in all 13 ICA-posi

Angular distributions in t t ¯ H (H →b b ¯) reconstructed events at the LHC

The associated production of a Higgs boson and a top-quark pair, tt¯H, in proton-proton collisions is addressed in this paper for a center of mass energy of 13 TeV at the LHC. Dileptonic final states of tt¯H events with two oppositely charged leptons and four jets from the decays t→bW+→b+ν, t¯→b¯W-→b¯-ν¯ and h→bb¯, are used. Signal events, generated with MadGraph5-aMC@NLO, are fully reconstructed