Subarachnoid hemorrhage (SAH) is associated with increased cerebral artery sensitivity to vasoconstrictors and release of the perivascular sensory vasodilator CGRP. In the current study the constrictive phenotype and the vasodilatory effects of exogenous and endogenous perivascular CGRP were characterized in detail applying myograph technology to cerebral artery segments isolated from experimental

Background: The main aim of the present population-based study was to compare drugs in fall versus non-fall accidents causing major trauma, including both clinical and medico-legal autopsy data. Methods: All individuals with accidents resulting in major trauma, a new injury severity score (NISS) > 15 or lethal outcome was identified at hospital and/or the Department of Forensic Medicine between 20

Researching intimacies and new media encompasses a wide variety of intersecting practices and relationships. This special issue presents contributions from researchers who are investigating practices of intimacy mediated either wholly or in part through new media in which a variety of different methodological opportunities and challenges are highlighted and discussed. Existing research has address

Festskriften till Håkan Hydén uppmärksammar att det 2018 är 40 år sedan Hydén disputerade, 30 år sedan Hydén blev professor i rättssociologi vid Lunds universitet och 10 år sedan Hydén blev innehavare av professuren till minne av Samuel von Pufendorf vid samma universitet. Festskriften innehåller bidrag från ca 60 forskare från olika universitet, från flera olika länder och med flera olika ämnesti

Kapitlet beskriver hur kritiken mot den straffrättsliga behandlingstanken formulerades av dåtidens radikala jurister och hur feministisk kritik mot av- och nedkriminalisingar på sexualbrottsområdet kom att forma ett kriminalpolitiskt perspektivskifte. Utgångspunkten är att 1970-talet utgör en kriminalpolitisk vändpunkt och att det därför är viktigt att återkommande reanalysera genom närläsningar a

Personers riskuppfattning påverkas av flera faktorer, som närheten till tidigare händelser, egna erfarenheter (utbildning och social kontext) och vad som kommuniceras. Detta innebär att både budskapsgivaren och mottagaren har stor betydelse för hur en kommunikationssituation utvecklas.Syftet med detta delprojekt, som är en del av projektet ”Nätverk vid upptäckt av befolkningsexponering fo

Background: The persistent environmental contaminants perfluoroalkyl substances (PFASs) have gained attention due to their potential adverse health effects, in particular following early life exposure. Information on human fetal exposure to PFASs is currently limited to one report on first trimester samples. There is no data available on PFAS concentrations in fetal organs throughout all three tri

About one third of the food produced globally is wasted along the food chain, representing a burden for the environment and an inefficiency of the food system. Tackling food waste is a priority on the global political agenda to guarantee food security. Defining a methodology for food waste quantification is key to monitoring progress towards the achievement of reduction targets. This paper summari

Objectives: Nailfold capillaroscopy is being increasingly used by rheumatologists in the diagnosis of SSc. However, assessment of all nailfolds can be time-consuming in a busy outpatient clinic. Our aim was to answer the question as to how many (and which) fingers a clinician should routinely assess to capture accurately the true state. Methods: A total of 2994 assessments (by an international pan

Background and Purpose- We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods- Copy number variation was identified in high-density single-nucleotide polymorphism microarray data of IS patients from the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) and SiGN (Stroke Genetics Network)/GISCOME (Genetics of Ischaemic Stroke Fu

Skeletal stem cells (SSCs) are present in bone marrow (BM) and offer great potential for bone regenerative therapies. However, in the absence of a unique marker, current sorting approaches remain challenging in the quest for simple strategies to deliver SSCs with consistent regeneration and differentiation capacities. Microfluidics offers the possibility to sort cells marker-free, based on intrins

Chronic lymphocytic leukemia (CLL) stereotyped subsets #6 and #8 include cases expressing unmutated B cell receptor immunoglobulin (BcR IG) (U-CLL). Subset #6 (IGHV1-69/IGKV3-20) is less aggressive compared to subset #8 (IGHV4-39/IGKV1(D)-39) which has the highest risk for Richter's transformation among all CLL. The underlying reasons for this divergent clinical behavior are not fully elucidated.

Portable and autonomous analytical instrumentation is becoming more important. Portable instrumentation can be designed via the miniaturization approach and this is a challenging task due to: (i) the limited battery power supply, (ii) a low number of mechanical and moving parts allowed in the design and (iii) susceptibility to changing environment and temperature fluctuations. In this work we desc

BACKGROUND: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF. METHODS: We meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hi

Patients with heart failure with left ventricular (LV) dyssynchrony often do not respond to cardiac resynchronization therapy (CRT), indicating that the pathophysiology is insufficiently understood. Intracardiac hemodynamic forces computed from four-dimensional (4-D) flow MRI have been proposed as a new measure of cardiac function. We therefore aimed to investigate how hemodynamic forces are alter

Social entrepreneurship research highlights the collaborative nature of social entrepreneurial efforts. Further, acknowledging the embeddedness of social ventures in the wider socio-economic and cultural context, the literature stresses the need to move our analysis from the micro-level of intra-organisational practices to the meso-level of inter-organisational dynamics. To answer to these calls,

Background: Even though identical blood group matching between recipient and donor is preferred, it is still not clear by how much this improves the outcome for patients who received a lung transplant (LTx), or whether there is any survival benefit. Earlier studies have yielded ambiguous results and few have investigated long-term survival. The aim of this study is, therefore, to explore the diffe