Retinal progenitor cell xenografts to the pig retina: immunological reactions.
We evaluated the host response to murine retinal progenitor cells (RPCs) following transplantation to the subretinal space (SRS) of the pig. RPCs from GFP mice were transplanted subretinally in 18 nonimmunosuppressed normal or laser-treated pigs. Evaluation of the SRS was performed on hematoxylin-cosin (H&E)-stained sections. Serum samples were taken from naive and RPC-grafted pigs and mouse-r