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Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years
The Perseverance rover (Mars 2020) mission, the first step in NASA’s Mars Sample Return (MSR) program, will select samples for caching based on their potential to improve understanding Mars’ astrobiological, geological, geochemical, and climatic evolution. Geochronologic analyses will be among the key measurements planned for returned samples. Assessing a sample’s shock history will be critical be
Embedded-cluster models of crystalline solids are important to allow accurate wave function methods to be applicable to solids. The ab-initio model potential method, in which the crystal is divided into three different fragments, one quantum fragment, one ab-initio model potential fragment and one point-charge fragment, has historically been shown to be a viable tool for describing the electronic
Embedded-cluster models of crystalline solids are important to allow accurate wave function methods to be applicable to solids. The ab initio model potential method for embedding ionic solids has historically been shown to be a viable tool. While useful, the method has been limited by the need to generate such potentials for each crystal structure and the lack of a freely available program for gen
Our recent work on mitral and tricuspid valve tracking in cardiovascular magnetic resonance (CMR) imaging to obtain accurate evaluations of longitudinal myocardial valve motion (both relaxation and contraction) has enabled an automated diastolic function assessment (e') with CMR. Its time-resolved capability allows a further evaluation of the valve dynamics by providing valve dimension measurement
This paper explores intensive motherhood and educational desires in contemporary Singapore. Singapore’s education system is globally renowned for its high academic standards and for producing students who excel in international assessment tests and rankings. At the same time, there has been a shift of attention in education policy towards social-emotional competencies and well-being. While a top-n
This review compares the methodology of published clinical studies investigating the extended-half-life (EHL) factor VIII (FVIII) products, rFVIIIFc (efmoroctocog alfa, Elocta®/Eloctate®), BAY 94-9027 (damoctocog alfa pegol, Jivi®), BAX 855 (rurioctocog alfa pegol, Adynovate®) and N8-GP (turoctocog alfa pegol, Esperoct®) including the phase 2/3 studies, A-LONG (NCT01181128), PROTECT VIII (NCT01580
Nanomaterials can adsorb biomolecules to their surface and form a protein corona. Here we investigated the protein profile bound to different sizes of aminated and carboxylated polystyrene (PS) nanoparticles after passing through the digestive tract of the freshwater zooplankter Daphnia magna. We found that acutely toxic aminated 53 nm PS nanoparticles bind a different set of proteins compared to
We describe a deep learning method to read hand-written records from the 16th century. The method consists of a combination of a segmentation module and a Handwritten Text Recognition (HTR) module. The transformer-based HTR module exploits both language and image features in reading, classifying and extracting the position of each word on the page. The method is demonstrated on a unique historical
This review presents state-of-the-art knowledge and identifies knowledge gaps for future research in the area of exercise-associated modifications of infection susceptibility. Regular moderate-intensity exercise is believed to have beneficial effects on immune health through lowering inflammation intensity and reducing susceptibility to respiratory infections. However, strenuous exercise, as perfo
Focusing on welfare challenges and crises encountered by women in contemporary Vietnam, this article examines the gendering of morality and the ways in which a feminized ethics of care is entangled with women’s practice of the social capacity tình cảm (sentiments/feelings/emotions). Drawing on data from the Industrial Zones of northern Vietnam, the article highlights how low-income workers are ren
The aim of this study was to examine the association between watching pornography and poor mental health in three repeated cross-sectional surveys in Sweden (2004, 2009, 2014) among high school seniors (13,277 students) with an average age of 18 years. The same index questions concerning ever having watched pornography and the frequency of watching pornography during the last year were combined wi
Objective: To evaluate the success rate of Extracorporeal Shock Wave Lithotripsy (ESWL) therapy and identify relevant treatment-specific factors affecting stone-free rate (SFR) after ESWL. Materials and methods: All ESWL treatments in the years 2016–2019, in Ängelholm Hospital, Skåne, Sweden were analysed retrospectively. Primary outcome was stone-free rate (SFR) at 3 months. Univariate logistic r
Background: Intraventricular hemorrhage causes significant lifelong mortality and morbidity, especially in preterm born infants. Progress in finding an effective therapy is stymied by a lack of preterm animal models with long-term follow-up. This study addresses this unmet need, using an established model of preterm rabbit IVH and analyzing outcomes out to 1 month of age. Methods: Rabbit pups were
Approximately 5% of patients with colorectal cancer (CRC) have a Mendelian predisposition for the disease. Identification of the disease-causing genetic variant enables carrier testing and tailored cancer prevention within affected families. To determine the panorama and genetic variation of Mendelian CRC syndromes among referrals at the cancer genetics clinics in Sweden, 850 patients clinically s
STOFFENMANAGER® and the Advanced REACH Tool (ART) are recommended tools by the European Chemical Agency for regulatory chemical safety assessment. The models are widely used and accepted within the scientific community. STOFFENMANAGER® alone has more than 37 000 users globally and more than 310 000 risk assessment have been carried out by 2020. Regardless of their widespread use, this is the first
