Bone marrow resident hematopoietic stem cells differentiate into all different types of lymphoid populations, there among mature naive B cells expressing IgM and IgD. During the maturation, the B cells are subjected to several steps of selection to ensure proper development of the antigen receptor. The mechanisms regulating the selection are to great extent unknown. In paper I of this thesis, we d

This Norm focussing article starts exploring the various influence processes that take place in connection with the dawn of a new theme - the environment and then sustainable development - in today's society. The Swedish society has in the early 1990-ies declared that educational institutions, places designed for the intentional influence, shall utilise the new environmental theme in its practice.

Antologin Kritiska gemenskaper är en vänbok till professor Diana Mulinari vid Lunds universitet. Medverkande i antologin är: Malinda Andersson, Signe Arnfred, Anna Bredström, Cynthia Cockburn, Paulina de los Reyes, Maud Eduards, Suvi Keskinen, Wuokko Knocke, Gail Lewis, Mia Liinason, Carina Listerborn, Åsa Lundqvist, Catrin Lundström, Chandra Talpade Mohanty, Irene Molina, Anders Neergaard, Tiina

Popular Abstract in Swedish Parkinsons sjukdom är en av de vanligaste neurodegenerativa sjukdomarna och orsakas av en selektiv förlust av dopaminerga neuron i mellanhjärnans substantia nigra (SN). Detta leder till en minskad mängd dopamin (DA) i hjärnans motoriska centrum, striatum, vilket orsakar de karakteristiska symptomen bradykinesi, muskelrigiditet och tremor. Förlusten av DA neuron i SN skeParkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra, leading to a loss of dopamine in the target structure striatum and development of motor symptoms, such as bradykinesia, rigidity and tremor. New experimental treatment strategies for Parkinson's disease are aimed at either preventing the degeneration of the dopaminergic neurons, or a

This work presents a fully-functional, microfabricated electrochemical-cantilever hybrid platform with flow control. A new cantilever chip format is designed, fabricated, and mounted in a custom polymer flow cell. Issues such as leakage and optical/electrical access are addressed, and combined mechanical and electrochemical performance is investigated. Lastly, a cantilever is “defunctionalized” in

Abstract is not available

A simulation model for embedding the bias of a transistor is presented. The model exploits the simulator equilibrium point calculation to set the bias point of the transistor. The model uses negative feedback to set the bias point according to what the designer desires. When the simulator goes into its main analyses, the negative feedback is broken and embedded bias sources are added. This way it

A family of 340-bp tandem telomere-associated DNA repeats is present in 50- to 200-kb blocks in seven of the eight paired chromosome ends in Chironomus pallidivittatus. It consists of four main subfamilies, differing from each other by small clusters of mutations. This differentiation may reflect different functional roles for the repeats. Here we find that one subfamily, D3, is consistently local