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Skin autofluorescence, a measure of tissue accumulation of advanced glycation end products, is associated with subclinical atherosclerosis in coronary and carotid arteries

Background and aims: Skin autofluorescence (AF), a measure of tissue accumulation of advanced glycation endproducts (AGEs), has been associated with diabetes and cardiovascular disease. However, the association of skinAF with subclinical coronary atherosclerosis in the general population is largely unknown. Our study aimed toexamine the associations between skin AF and subclinical atherosclerosis

Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.

Aims: Skeletal muscle is a major metabolic organ and plays important roles in glucose metabolism, insulin sensitivity and insulin action. Muscle telomere length reflects the myocyte's exposure to harmful environmental factors. Leukocyte telomere length is considered a marker of muscle telomere length and is used in epidemiologic studies to assess associations with ageing-related diseases where mus

A multicentre, randomised, controlled, open-label pilot study on the feasibility of discontinuation of adalimumab in established patients with rheumatoid arthritis in stable clinical remission.

Treatment with tumour necrosis factor (TNF) blockers, once started as therapy for rheumatoid arthritis (RA), is usually continued indefinitely. The aim of this trial was to assess the possibility of discontinuing treatment with adalimumab (ADA) while maintaining remission in patients with RA with established disease in stable remission on combination therapy with ADA and methotrexate (MTX).

The electromagnetic field in a layered earth induced by an arbitrary stationary current distribution

The subject of this paper is to calculate the fields in a layered earth induced by a current distribution. A general formulation is presented, which contains very few restrictions of the current distribution. For the simplest current distributions (dipole, circular, and rectangular loops) we derive expressions for the fields, which contain a single integral (Sommerfeld type). Numerical computation

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Since the latest update of the checklist on bees known from Denmark, the following three species have been added as new to the country: Colletes halophilus Verhoeff, 1943 (Colletidae), Nomada obscura Zetterstedt, 1838 (Apidae) and Xylocopa violacea (Linnaeus, 1758) (Apidae). The national checklist hereby includes 286 bee species, but more species will probably be found in the future, as the wild b

Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease.

Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurod

Third trimester assessment of the uterine scar in women with prior caesarean: what is the evidence?

The increasing rate of caesarean delivery is a worldwide concern. A major contributor to this evolution has been a concomitantly decline in vaginal birth after caesarean, because of the risk of intrapartum uterine rupture, which is a rare but potentially catastrophic complication of a trial of labour after caesarean (TOLAC). On the other hand, elective repeat caesarean is associated with surgical

Effects of Walking Speed and Results of Timed Get-Up-and-Go Tests on Quality of Life and Social Participation in Elderly Individuals With a History of Osteoporosis-Related Fractures.

OBJECTIVE: To investigate the relationships between physical performance, quality of life (QoL), and social participation among elderly men and women with a history of osteoporosis-related fractures. METHOD: The study was a population-based cross-sectional study including 155 participants aged 60 to 93 years from the Swedish longitudinal investigation, "Good Aging in Skåne." The participants had s