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Uncovering sociodemographic disparities in temporal trends of osteoarthritis incidence and age-at-diagnosis, 2006-2019

AIM: To describe sociodemographic disparities in temporal trends of incidence and age distributions of first registered osteoarthritis (OA) diagnosis in southern Sweden.METHODS: We identified all Skåne residents aged 35+ who had lived in the region at any point during the period 2006-2019 with no previous OA diagnosis (ICD-10 codes M15-M19) for 8 years prior to inclusion in the study (n = 849,061)

Laparoscopic lavage vs primary resection for acute perforated diverticulitis : The SCANDIV randomized clinical trial

IMPORTANCE: Perforated colonic diverticulitis usually requires surgical resection, which is associated with significant morbidity. Cohort studies have suggested that laparoscopic lavage may treat perforated diverticulitis with less morbidity than resection procedures. OBJECTIVE: To compare the outcomes from laparoscopic lavage with those for colon resection for perforated diverticulitis. DESIGN, S

Isolation of Amyloid by solubilization in water

Amyloid fibrils are highly insoluble in neutral aqueous media of regular ionic strengths making solubilization a difficult task that normally calls for extremely harsh treatment. This is among the reasons for the routine employment of synthetic proteins in amyloid research, where the amylogenic components are needed. Here we describe a process for solubilizing amyloid in pure water that we adopted

Solubilized cystatin C amyloid is cytotoxic to cultured human cerebrovascular smooth muscle cells

Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid within arteries of the cerebral cortex and leptomeninges. This condition is age related, especially prevalent in Alzheimer's disease (AD) and the main feature of certain hereditary disorders. The vascular smooth muscle cells (VSMC) appear to play a vital role in the development of CAA and have been found to produce t

Business model innovation factors of small and medium-sized enterprises in Bolivia

This paper aims to explore how four Bolivian small and medium-sized enterprises’ business has overcome the gaps in reliance on traditional small and medium-sized enterprises’ business models, i.e., to extract and sell raw unrefined natural resources in a local area, and instead make productive use of innovation inputs (technology, higher-educated people) by innovating their business models. We wer

Modelling and analysis of multi-scale networks

The broad goal of this thesis is to develop a deeper mathematical understanding of the processes at work in the neuronal network of a brain by rigorously examining very fundamental elements of the processes involved. Paper I considers the flow of discrete signals on a graph and Paper II the complexity arising from the interplay of simple units. The concrete probabilistic investigations of such mod

Conceptualization of a minority between a strategical mechanism of absorption and a tactical tool for recognition: The Constitutional Court judgements on the political party bans in Turkey

This chapter analyzes five cases in which the Turkish Constitutional Court banned political parties, advocating for equal citizenship rights for the Kurdish people, based on their alleged violation of the law on political parties, which prohibits claims of the existence of minorities. The chapter aims to explore the conceptualization of minority rights within the juridico-political realm of Turkey

Making warming worlds : Future making between climate politics and science – The case of the Structured Expert Dialogue

The Long-Term Global Goal (LTGG) is the focal point for addressing future climate change. This paper explores a specific institutional context: the Structured Expert Dialogue (SED) of the UN Framework Convention on Climate Change (UNFCCC). Set up as a platform for interaction between experts and UN negotiators, the SED is a site where scientific information about the LTGG and net-zero was translat

Towards a service life extension of the Øresund Fixed Link

The Øresund Fixed Link is a 15,9 km road and railway connection between the southerly Swedish city of Malmö and its neighbor across the Øresund strait, Copenhagen, in Denmark. The link, which opened in 2000, consists of an elevated bridge, including a high stay cable bridge, an artificial island, as well as a submerged tunnel. The operators of the link, Øresundsbron Consortium, have recently, as p

Transforming a Synthetic World : The Political Economy of Petrochemical Transitions

Operating enormous, integrated refineries and clusters, the petrochemical industry runs processes in which hydrocarbons are turned into the fundamental components for plastics and other synthetic materials. Continuing a historical trend of consistent output growth, petrochemicals are the largest current driver of oil demand growth. At the same time, the industry is under increasing pressure to tra

Delivering Transit Oriented Development (TOD) in low to medium density contexts. Actor relationships and market conditions in smaller Swedish cities

This article analyses actor relationships in Transit Oriented Development (TOD) planning in order to better understand the preconditions necessary for planning processes to result in TOD in lower density contexts, in suburbs, or small cities. Empirically, the analysis builds on a comparative case study of TOD planning projects. The focus in the analytical work is on understanding how market condit

Non-linear Extreme Ultraviolet Applications with Attosecond Pulses

In recent years laser driven attosecond sourcesAttosecond sources based on loose geometry high order harmonic generationHigh order harmonic generation reach focused intensities as high as to induce multi-photonMulti-photonmultiple ionizationMultiple ionization or even strong -field effectsEven strong-field effects in the extreme ultraviolet spectral range. In this chapter, we review four such sour