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Liquid-based cytology using cytorich Red/Tripath is diagnostically equivalent to conventional smears for bronchial washings and brushings and reduces the cost.

A split sample study was performed on 109 bronchial brushings and washings and evaluated from conventional slides (CS) and CytoRich Red/Tripath preparations (CRR/Tripath). Unassessable bronchial washings were significantly more frequent in CS (5 vs. 0), but as all brushings were assessable with both methods, no overall diagnostic advantage was found. CS and CRR/Tripath gave discordant diagnoses in

Climatic Thermal Stresses in the Vätösund Box-Girder Concrete Bridge

Severe cracks have been found in several box-girder bridges in Sweden, with the cracks being more frequent on the south side than the north. This indicates that solar radiation has a large impact on the stress field of these bridges, since this is the only factor that is significantly different between the walls. In this study the Vätösund Bridge has been modelled in a 3D FE-model to analyse the t

Streptococcal M1 Protein-Provoked CXC Chemokine Formation, Neutrophil Recruitment and Lung Damage Are Regulated by Rho-Kinase Signaling.

Streptococcal toxic shock syndrome is frequently caused by Streptococcus pyogenes of the M1 serotype. The aim of this study was to determine the role of Ras-homologous (Rho)-kinase signaling in M1 protein-provoked lung damage. Male C57BL/6 mice received the Rho-kinase-specific inhibitor Y-27632 before administration of M1 protein. Edema, neutrophil accumulation and CXC chemokines were quantified i

The effect of systematic set-up deviations on the absorbed dose distribution for left-sided breast cancer treated with respiratory gating

The aim of this study was 1) to investigate interfraction set-up uncertainties for patients treated with respiratory gating for left-sided breast cancer, 2) to investigate the effect of the inter-fraction set-up on the absorbed dose-distribution for the target and organs at risk (OARs) and 3) optimize the set-up correction strategy. By acquiring multiple set-up images the systematic set-up deviati

From words to action: Concepts, framings of problems and knowledge production practices in regional transport infrastructure planning in Sweden

This paper presents an analysis of a regional transport infrastructure plan in Sweden. A comparison is made of two concepts central to transport infrastructure planning in Sweden; Regional expansion and Environmentally sound transport. These concepts signify different perspectives on the benefits and problems with transport. The analysis explains how these clashing perspectives are resolved in the

Learning Stimulus Intervals – Adaptive Timing of Conditioned Purkinje Cell Responses

Classical conditioning of motor responses, such as the eyeblink response, is an experimental model of associative learning and of adaptive timing of movements. A conditioned blink will have its maximum amplitude near the expected onset of the unconditioned blink-eliciting stimulus and it adapts to changes in the interval between the conditioned and unconditioned stimuli. Previous studies have show

Interfacial Molecular Imprinting in Nanoparticle-Stabilized Emulsions.

A new interfacial nano and molecular imprinting approach is developed to prepare spherical molecularly imprinted polymers with well-controlled hierarchical structures. This method is based on Pickering emulsion polymerization using template-modified colloidal particles. The interfacial imprinting is carried out in particle-stabilized oil-in-water emulsions, where the molecular template is presente

A Compartmental Model for Biokinetics and Dosimetry of 18F-Choline in Prostate Cancer Patients

PET with F-18-choline (F-18-FCH) is used in the diagnosis of prostate cancer and its recurrences. In this work, biodistribution data from a recent study conducted at Skane University Hospital Malmo were used for the development of a biokinetic and dosimetric model. Methods: The biodistribution of F-18-FCH was followed for 10 patients using PET up to 4 h after administration. Activity concentration

Prognostic sub-classifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark's level of invasion. Results of a population-based study from the Swedish Melanoma Register.

Background: Survival and prognostic factors for thin melanomas have been relatively little studied in population-based settings. This patient group account for the majority of melanomas diagnosed in western countries today and better prognostic information is needed. Objective: The aim of this study is to use established prognostic factors such as ulceration, tumour thickness and Clark's level of

The ca. 1380 Ma Mashak igneous event of the Southern Urals

A review of the geochronology, geochemistry and distribution of the 1380 Ma Mashak Large Igneous Province (LIP) of the eastern margin of the East European craton indicates a potential link to a major breakup stage of the Mesoproterozoic supercontinent Columbia (Nuna), link to a major stratigraphic boundary (Lower-Middle Riphean), and economic significance for hydrocarbons and metallogeny. Specific

Controversial role of toll-like receptors in acute pancreatitis.

Acute pancreatitis (AP) is a common clinical condition with an incidence of about 300 or more patients per million annually. About 10%-15% of patients will develop severe acute pancreatitis (SAP) and of those, 10%-30% may die due to SAP-associated complications. Despite the improvements done in the diagnosis and management of AP, the mortality rate has not significantly declined during the last de

Genome methylation patterns in male breast cancer - Identification of an epitype with hypermethylation of polycomb target genes.

Male breast cancer (MBC) is a rare disease that shares both similarities and differences with female breast cancer (FBC). The aim of this study was to assess genome-wide DNA methylation profiles in MBC and compare them with the previously identified transcriptional subgroups of MBC, luminal M1 and M2, as well as the intrinsic subtypes of FBC. Illumina's 450K Infinium arrays were applied to 47 MBC

Heterogeneous and Complex Rearrangements of Chromosome Arm 6q in Chondromyxoid Fibroma. Delineation of Breakpoints and Analysis of Candidate Target Genes.

Chondromyxoid fibroma (CMF) is an uncommon benign cartilaginous tumor of bone usually occurring during the second decade of life. CMF is associated with recurrent rearrangements of chromosome bands 6p23-25, 6q12-15, and 6q23-27. To delineate further the role and frequency of the involvement of three candidate regions (6q13, 6q23.3 and 6q24) in the pathogenesis of CMF, we studied a group of 43 case

Double-spin asymmetry of electrons from heavy-flavor decays in p plus p collisions at root s=200 GeV

We report on the first measurement of the double-spin asymmetry, A(LL), of electrons from the decays of hadrons containing heavy flavor in longitudinally polarized p + p collisions at root s = 200 GeV for p(T) = 0.5 to 3.0 GeV/c. The asymmetry was measured at midrapidity (vertical bar eta vertical bar < 0.35) with the PHENIX detector at the Relativistic Heavy Ion Collider. The measured asymmetries

Relationship of 3D meniscal morphology and position with knee pain in subjects with knee osteoarthritis: a pilot study

To explore whether quantitative, three-dimensional measurements of meniscal position and size are associated with knee pain using a within-person, between-knee study design. We studied 53 subjects (19 men, 34 women) from the Osteoarthritis Initiative, with identical radiographic OA grades in both knees, but frequent pain in one and no pain in the other knee. The tibial plateau and menisci were ana

Behavioural syndromes at multiple scales in Myrmica ants

Behavioural syndromes (correlations between suites of behavioural traits) have been documented in a wide range of animals and are important for the understanding of evolution and ecology. Previous research has focused primarily on behavioural syndromes composed of individual animals: we investigated behavioural syndromes at the individual, caste and colony levels in Myrmica ants. We first related

Using NMR Chemical Shift Imaging To Monitor Swelling and Molecular Transport in Drug-Loaded Tablets of Hydrophobically Modified Poly(acrylic acid): Methodology and Effects of Polymer (In)solubility

A new technique has been developed using NMR chemical shift imaging (CSI) to monitor water penetration and molecular transport in initially dry polymer tablets that also contain small low-molecular weight compounds to be released from the tablets. Concentration profiles of components contained in the swelling tablets could be extracted via the intensities and chemical shift changes of peaks corres

Mapping daily evapotranspiration and dryness index in the East African highlands using MODIS and SEVIRI data

Routine information on regional evapotranspiration (ET) and dryness index is essential for agricultural water management, drought monitoring, and studies of water cycle and climate. However, this information is not currently available for the East Africa highlands. The main purpose of this study is to develop (1) a new methodology that produces spatially gridded daily ET estimates on a (near) real

Rethinking the Univariate Approach to Panel Unit Root Testing: Using Covariates to Resolve the Incidental Trend Problem: Using Covariates to Resolve the Incidental Trend Problem

In an influential paper, Hansen (Rethinking the Univariate Approach to Unit Root Testing: Using Covariates to Increase Power, Econometric Theory 11, 1148–1171, 1995) shows that covariate augmentation can lead to substantial power gains when compared to univariate tests. In this paper we ask if this result extends also to the panel data context? The answer turns out to be yes, which is maybe not th