Molecular dynamics (MD) simulations are a powerful approach to studying the structure and dynamics of proteins related to health and disease. Advances in the MD field allow modeling proteins with high accuracy. However, modeling metal ions and their interactions with proteins is still challenging. NPL4 is a zinc-binding protein and works as a cofactor for p97 to regulate protein homeostasis. NPL4

Fires involving electric vehicles have attracted considerable attention in the media. In particular, the toxic gases released upon combustion of electric vehicles and lithium-ion batteries has been a major concern. In this study, the results of six large-scale vehicle fire tests are presented including three electric vehicles, two internal combustion engine vehicles, and one electric vehicle with

Astroglial dysfunction contributes to the pathogenesis of Huntington s disease (HD), and glial replacement can ameliorate the disease course. To establish the topographic relationship of diseased astrocytes to medium spiny neuron (MSN) synapses in HD, we used 2-photon imaging to map the relationship of turboRFP-Tagged striatal astrocytes and rabies-Traced, EGFP-Tagged coupled neuronal pairs in R6/

Background: Patients with intermittent claudication need lifelong treatment with secondary prevention to prevent cardiovascular events and progression of atherosclerotic disease. Illness perception, health literacy, self-efficacy, adherence to medication treatment, and quality of life are factors influencing patients’ self-management. Knowledge of these factors could be important when planning for

The rainfall product derived from the SM2RAIN (Soil Moisture to Rain) algorithm has been widely used. However, there is still a large uncertainty partly due to the soil moisture input and parameters estimation of the SM2RAIN algorithm, which limits the application of the model in alpine regions. Here, the SM2RAIN-BayesOpt algorithm was developed by integrating the SM2RAIN algorithm and Bayesian op

Background: Nausea and vomiting in pregnancy (NVP) affects 50–80% of pregnant women and is correlated to the level of human chorionic gonadotropin (hCG). Hyperemesis gravidarum (HG) is a severe condition, with an incidence of 0.2–1.5%, characterized by consistent nausea, vomiting, weight loss and dehydration continuing after the second trimester. Aim: The aim of this systematic review was to inves

For two-dimensional steady pure-gravity water waves with a unidirectional flow of constant favorable vorticity, we prove an explicit bound on the amplitude of the wave, which decays to zero as the vorticity tends to infinity. Notably, our result holds true for arbitrary water waves, that is, we do not have to restrict ourselves to periodic or solitary or symmetric waves.

Tumor antigens can emerge through multiple mechanisms, including translation of noncoding genomic regions. This noncanonical category of tumor antigens has recently gained attention; however, our understanding of how they recur within and between cancer types is still in its infancy. Therefore, we developed a proteogenomic pipeline based on deep learning de novo mass spectrometry (MS) to enable th

Background: Complex level-of-care decisions involve uncertainty in which decisions are beneficial for older patients. Knowledge of physicians’ decision-making during acute situations in older patients’ homes is limited. Therefore, this study aimed to describe physicians’ experiences and actions in making complex level-of-care decisions during the assessment of older patients in acute situations wi

Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα patients with thyroxine to overcome tissue hormone resistance does not elevate their heart rate. Cardiac telemetry in male, TRα1 mutant, mice indicates that such persis

Background: To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predomi

In this chapter, it is argued that Mary Wollstonecraft’s (1759–1797) writings on morality and politics are usefully analyzed as comprehensive critique of hierarchy and inequality, as detrimental to freedom and virtue. Focus is placed on Wollstonecraft’s approach to doing philosophy, or her method. She regarded inequalities as moral deviations from proper standards of rightness but also as continge

The 1990s and 2000s have seen a rapidly growing use of flow field-flow fractionation (flow FFF, FlFFF). As of today hundreds of publications in many different application areas are presented each year in which flow FFF has been used or is referred to. In this chapter a brief historical overview of flow FFF is given. Channel designs and basic principles are discussed as well as approaches to develo

Denna uppsats behandlar möjligheterna att begå brottet köp av sexuell tjänst på distans. Undersökningen tar avstamp i en närmare undersökning av brottet i sig. I denna konstateras att den straffbara gärningen, tillfällig sexuell förbindelse mot ersättning, knyter an till det i övrigt upphävda begreppet sexuellt umgänge. Brotten i 6 kap. BrB som enligt gällande rätt kan begås på distans knyter an tThis thesis explores the possibilities of committing the crime purchase of sexual service remotely. The investigation begins with a closer examination of the offense itself. It is noted that the punishable act “casual sexual relation in return for payment”, is closely related to the abolished term “sexual intercourse”. The crimes in chapter six in the Swedish Criminal Code that currently can be co

Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incor

This longitudinal study examined the relationship between flexibility-activity and blood-pressure (BP) change among older adults in Japan. Our study included 452 older adults who took part in our survey in both 2012/2013 and 2017/2018. The seated systolic blood pressure (SBP) and diastolic BP (DBP) were measured both at baseline and at the 5 years follow-up. The frequencies of the different physic

Payments for ecosystem services (PES), a mechanism of incentives or compensation to landowners for provision of ecosystem services, have grown as a tool for meeting conservation goals. The Costa Rican payments for ecosystem services (PSA) program is one of the best-known examples because of being one of the most established. Despite this, the PSA program and many other PES programs do not monitor

Background: Selection pressure exerted by pathogens can influence patterns of genetic diversity in the host. In the immune system especially, numerous genes encode proteins involved in antagonistic interactions with pathogens, paving the way for coevolution that results in increased genetic diversity as a consequence of balancing selection. The complement system is a key component of innate immuni

INTRODUCTION If a family is discharged from a hospital earlier after birth, close supervision by a skilled midwife is essential. The aim was to describe mothers’ overall experience receiving postnatal care in a Swedish home-based midwifery care model. METHODS A descriptive qualitative study was conducted. Mothers meeting the inclusion criteria for a new home-based postnatal care model at a hospita

Introduction Pressure-volume (PV) loops can be used to assess both load-dependent and load-independent measures of cardiac hemodynamics. However, analysis of PV loops during exercise is challenging as it requires invasive measures. Using a novel method, it has been shown that left ventricular (LV) PV loops at rest can be obtained non-invasively from cardiac magnetic resonance imaging (CMR) and bra