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Kinins are potent proinflammatory peptides that are produced extracellularly and rapidly degraded by extracellular peptidases and by intracellular peptidases accessed by kinins via receptor-mediated endocytosis. Here, we developed model cell systems expressing the kinin B2 receptor (B2R) and the metalloendopeptidase thimet oligopeptidase (EC 3.4.24.15; EP24.15) either individually or together to a

The suppressors of cytokine signaling (SOCS) are well-known negative regulators of cytokine receptor signaling. SOCS6 is one of eight members of the SOCS family of proteins. Similar to other SOCS proteins, SOCS6 consists of an uncharacterized extended N-terminal region followed by an SH2 domain and a SOCS box. Unlike other SOCS proteins, SOCS6 is mainly involved in negative regulation of receptor

The closely related receptor tyrosine kinases c-Kit and Flt3 are mainly expressed in hematopoietic cells and are involved in driving cell proliferation and promoting survival in response to growth factor stimulation. Several gain-of-function mutations of both c-Kit and Flt3 have been found in malignancies like acute myeloid leukemia, gastrointestinal stroma tumors and small cell lung carcinomas, a

In many countries, current research policy is dominated by managerialism and excellence, manifesting the aim of making universities into national strategic assets in the globally competitive knowledge economy. This article discusses these policy trends and their mirror in recent developments in public funding for academic research, with special attention to Sweden. A review of the language in thre

Resilience of ecological communities to perturbation is important in the face of increased global change from anthropogenic stressors. Monitoring is required to detect the impact of, and recovery from, perturbations, and before-after-control-impact (BACI) analysis provides a powerful framework in this regard. However, species in a community are not observed with perfect detection, and occupancy an

We consider stochastic population processes (Markov jump processes) that develop as consequence of the occurrence of randon events at random time-inervals. The population is divided into sub-populations or compartments. The events occur at rates that depend linearly with the number of individuals in the different described compartments. The dynamics is presented in terms of a Kolmogorov Forward Eq

The variations in tropospheric transport pathways over a 20 year period, 1990-2009, are studied at six locations in Europe. Three Atlantic (Lisbon, Mace Head, and Cabauw) and three Mediterranean sites (Malaga and Elche in the western part and Lecce in the central Mediterranean) are considered. The work is based on the identification of flow types at each location by robust cluster analysis of the

Background: Hip dislocation is a serious complication among children with cerebral palsy (CP). The aim of this study was to compare the prevalence of hip dislocation among children with CP in an area providing regular care with an area providing hip surveillance services. Methods: This is a cross-sectional study in seven Norwegian counties providing regular care and one Swedish healthcare region w

The purpose of this study was to assess the reliability and construct validity of the Spanish version of the 6-item carpal tunnel syndrome (CTS) symptoms scale (CTS-6).

The activity concentration of (CS)-C-137, I-131, Zn-65, Co-60, Co-58, Mn-54, and K-40 were determined in samples of brown seaweed (Fucus) and some other marine plants using low background high-resolution gamma-spectrometry. The algae were mainly sampled in the bay just north of the Barseback NPP (55.4 N, 12.6 E) in the south of Sweden to study the contamination levels in the nearest shallow waters

We report on the multi-wavelength observations of PKS 1510-089 (a flat spectrum radio quasar (FSRQ) at z = 0.361) during its high activity period between 2008 September and 2009 June. During this 11 month period, the source was characterized by a complex variability at optical, UV, and gamma-ray bands, on timescales down to 6-12 hr. The brightest gamma-ray isotropic luminosity, recorded on 2009 Ma

This paper focuses on the institutional framework for sulfur dioxide emission information disclosure (SDEID) in power industries. The authors argue that mandatory and voluntary SDEID are two complementary regulatory instruments for emission reduction in the power industry. An analytical framework of SDEID with six facets is suggested in this paper to demonstrate relevant legal provisions and regul

Ventilator-associated pneumonia (VAP) is a common complication of respiratory support and is associated with increased mortality, morbidity and costs, and a prolonged stay in the intensive care unit. Scandinavian data on the aetiology in VAP are lacking. We hereby present a retrospective study on the aetiology of VAP diagnosed by protective specimen brush culture at Malmo University Hospital in re

Solar energy harvesting for electricity production is regarded as a fully credible future energy source: plentiful and without serious environmental concerns. The breakthrough for solar energy technology implementation has, however, been hampered by two issues: the conversion efficiency of light into electricity and the solar panel production cost. The use of III-V nanowires (NWs) in photovoltaics

The population of the high-spin states in Nd-140 was investigated using the reaction Zr-96(Ca-48,4n). The results from two experiments, one with the EUROBALL array and one with the JUROGAM II + RITU + GREAT setup employing the recoil decay tagging technique, have been combined to develop a very detailed level scheme for Nd-140. Twelve bands of quadrupole transitions and eleven bands of dipole tran

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A search for long-lived charged particles reaching the muon spectrometer is performed using a data sample of 37 pb(-1) from pp collisions at root s = 7 TeV collected by the ATLAS detector at the LHC in 2010. No excess is observed above the estimated background. Stable (tau) over bar sleptons are excluded at 95% CL up to a mass of 136 GeV, in GMSB models with N-5 = 3 , m(messenger) = 250 TeV, sign(

The influence on the fatigue crack growth behaviour of a short edge crack due to different configurations of a nearby located low angle grain boundary is investigated under quasi-static and plane strain conditions. The geometry is modelled by dislocation dipole elements in a boundary element approach, and the plasticity is modelled by discrete dislocations. The crack is assumed to grow in a single

Sterols are a class of membrane-reinforcing, ringed lipids which have a long history of examination in algae as a means of deriving chemotaxonomic relationships and as potential lipidic biomarkers. The Raphidophyceae represent a class of harmful, bloom-forming, marine and freshwater algae. To date, there have been four published examinations of their sterol composition, focusing primarily on brown