Selective serotonin reuptake inhibitors (SSRIs) have shown promise in cancer therapy, particularly for hepatocellular carcinoma (HCC), but their molecular targets and mechanisms remain unclear. Here, we show that SSRIs exhibit significant anti-HCC effects independent of their classical target, the serotonin reuptake transporter (SERT). Using global inverse gene expression profiling, drug affinity

INTRODUCTION: Overweight and obesity are linked to increased hospitalization and mortality in COVID-19 patients. This study aimed to characterize induced immune responses and deep immune cell profiles stratified by BMI in hospitalized COVID-19 patients.METHODS AND RESULTS: This observational multicenter cohort pilot study included 122 adult patients with PCR-confirmed COVID-19 in Denmark, stratifi

BACKGROUND: Vaccine breakthrough SARS-CoV-2 infections are common and of clinical and public health concern. However, little is known about the immunological characteristics of patients hospitalized due to these infections. We aimed to investigate and compare immune cell subpopulations and induced immune responses in vaccinated and non-vaccinated patients hospitalized with severe COVID-19.METHODS:

BACKGROUND: Adiponectin is secreted by adipocytes and is inversely associated with obesity. Given the association between low body mass index (BMI) and higher mortality risk after community-acquired pneumonia (CAP), we hypothesized that high adiponectin levels are associated with a higher risk of adverse clinical outcomes in patients with CAP.METHODS: In a prospective cohort study of 502 patients

BACKGROUND: To compare the intrinsic virulence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant with the delta variant in hospitalized adults with coronavirus disease 2019 (COVID-19).METHODS: All adults hospitalized in the Capital Region of Copenhagen with a positive reverse transcription polymerase chain reaction test for SARS-CoV-2 and an available variant dete

BACKGROUND: Viral shedding and neutralizing antibody (NAb) dynamics among patients hospitalized with severe coronavirus disease 2019 (COVID-19) and immune correlates of protection have been key questions throughout the pandemic. We investigated the duration of reverse transcriptase-polymerase chain reaction (RT-PCR) positivity, infectious viral shedding and NAb titers as well as the association be

Undernutrition is associated with increased mortality after hospitalization with community-acquired pneumonia (CAP), whereas obesity is associated with decreased mortality in most studies. We aimed to determine whether undernutrition and obesity are associated with increased risk of re-hospitalization and post-discharge mortality after hospitalization. This study was nested within the Surviving Pn

BACKGROUND: The immune pathogenesis underlying the diverse clinical course of COVID-19 is poorly understood. Currently, there is an unmet need in daily clinical practice for early biomarkers and improved risk stratification tools to help identify and monitor COVID-19 patients at risk of severe disease.METHODS: We performed longitudinal assessment of stimulated immune responses in 30 patients hospi

Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP caused by bacteria or influenza virus in hospital

BACKGROUND: Different pathogens can cause community-acquired pneumonia (CAP); however, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has re-emphasized the vital role of respiratory viruses as a cause of CAP. The aim was to explore differences in metabolic profile, body composition, physical capacity, and inflammation between pati

BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of hospitalization worldwide. Bed rest with low levels of physical activity is common during periods of hospitalization and leads to functional decline as well as increased risk of complications. The aim of this study is to assess the effect of supervised physical training during hospitalization with CAP compared with standard usual

OBJECTIVES: The presentation of sarcoidosis can involve symptoms from all organs and the diagnosis is therefore often difficult. A raised serum level of serum angiotensin-converting enzyme (sACE) can be detected in 41-58% of patients. However, whether the sACE level per se reflects the severity of the sarcoid inflammation at the onset of the disease is not well described. The purpose of this study

INTRODUCTION: People with neurodegenerative disorders (ND) frequently face diagnostic delay and misdiagnosis. We investigated blood and cerebrospinal fluid (CSF) neurofilament light chain (NfL) to distinguish ND from primary psychiatric disorders (PPD), a common challenge in clinical settings. METHODS: Plasma and CSF NfL levels were measured and compared between groups, adjusting for age, sex, and

This thesis investigates superfluidity in exotic phases of ultracold bosonic gases, namely self-bound droplets, mixed bubbles, and dipolar supersolids. We investigated these systems analytically and numerically using an extended Gross-Pitaevskii and Bogoliubov-de Gennes formalism. The dissertation offers six chapters, providing the necessary derivations to build the required background and underst

Order-picking is one of the costliest processes in warehouses and we investigate how it can be optimized using Software as a Service (SaaS). First, we describe three specific order-picking optimization problems: The Picker Routing Problem (PRP), the Order Batching Problem (OBP) and the Storage Location Assignment Problem (SLAP). The PRP is a type of Traveling Salesman Problem (TSP) where we find a

We analyze public-policy speeches in the Florentine Consulte e Pratiche, immediately prior to the Ciompi Revolt, for signs of elite factional conflict, in the context of self-proclaimed unity. We employ three statistical analyses of these speeches in Latin: namely, scatterplots of word frequencies, Wordfish scaling, and regressions on speech-similarities. Plus we employ two qualitative analyses: a

The Florentine Consulte e Pratiche is the oldest recorded series of speech-by-speech policy discussion by political elites in European history, over one hundred and fifty years in length. This article is the first of an extended two-article sequence on political discussion in the Consulte e Pratiche, during the 1376–1378 period of the War of Eight Saints, which led up to the famous Ciompi Revolt.

African intellectual traditions have much to offer social analysis, yet many historical African intellectuals remain obscured by history and peripheral to contemporary academic work. This paper turns to the writings of the prolific amaXhosa intellectual S.E.K. Mqhayi, exploring his social and political thought, and considering how his work can be taken as part of an African sociological tradition.