Melanocortin receptor accessory proteins (MRAPs) modulate signaling of melanocortin receptors in vitro. To investigate the physiological role of brain-expressed melanocortin 2 receptor accessory protein 2 (MRAP2), we characterized mice with whole-body and brain-specific targeted deletion of Mrap2, both of which develop severe obesity at a young age. Mrap2 interacts directly with melanocortin 4 rec

We present a new analysis of J/psi production yields in deuteron-gold collisions at root s(NN) =200 GeV using data taken from the PHENIX experiment in 2003 and previously published in S. S. Adler [Phys. Rev. Lett 96, 012304 (2006)]. The high statistics proton-proton J/psi data taken in 2005 are used to improve the baseline measurement and thus construct updated cold nuclear matter modification fac

The present work is based on the Kantian (AaO) axiom and conceptualised as a textbook. As scientific in the true sense of the notion science, the Vertex version of Perspective Text Analysis (PTA) represents a completely new approach to text-based studies. The inter-lingual character of Vertex has been tested and established in the context of six different languages, four belonging to the German fa

TPC stand alone simulations based on different energy loss models are compared to previously reported measurements with an ALICE TPC prototype. The performance obtained from simulations is shown to depend significantly on all the included detector effects stressing that energy loss model calculations alone are inadequate for describing the performance. When all effects are included, a good quantit

Recent advances in coherent multidimensional spectroscopy have boosted interest in exciton coherences in light harvesting complexes. We present nonperturbative calculations of two-dimensional (2D) electronic spectroscopy from a fifth-order phase-matching direction. The calculations show clear patterns that correspond to the electronic structure of one- and two-exciton manifolds of a Fenna-Matthews

Background. Over the last few decades, an increasing number of studies have suggested a connection between neurodevelopmental problems (NDPs) and body mass index (BMI). Attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) both seem to carry an increased risk for developing extreme BMI. However, the results are inconsistent, and there have been only a few studies of t

De vanligtvis beaktade fossilfria alternativen till dagens olje- och fossilgasbaserade drivmedel i transportsektorn är förnybar el, vätgas och biodrivmedel. De begränsningar, osäkerheter och problem som finns med batterier, vätgas och biodrivmedel gör det intressant att beakta möjligheterna att från el producera kolhaltiga drivmedel – flytande och gasformiga kolväten. Dessa så kallade elektrobräns

Knowledge of the morphology of Manota unifurcata LUNDSTRÖM, 1913 is deepened by a detailed description and illustration of the male genitalia. Based on a study of the characters of the male genitalia in specimens from various countries, it is reconfirmed that M. unifurcata is the only species of Manota WILLISTON in Europe. Its geographic distribution is reviewed, and is augmented by new records fr

The influence of adding poly(acrylic acids) of two different chain lengths (PAA(25) and PAA(6000)) on the phase behaviour of the amphiphilic triblock copolymer Pluronic (R) P104 (P104 = (EO)(27)(PO)(61)(EO)(27), where EO = ethylene oxide, PO = propylene oxide) in H2O was investigated. The resulting phase equilibria and structures were investigated by visual inspection, using crossed polarizers, an

Objective. To explore the influences of discrete positive and negative emotions on cooperation in the context of a social dilemma game. Design. Two controlled studies were undertaken. In Study 1, 69 participants were randomly assigned to an essay emotion manipulation task designed to induce either guilt, joy or no strong emotion. In Study 2, 95 participants were randomly assigned to one of the sam

This article sets out to study the ways in which reactions and adaptations to modernity and societal change among non-elite communities in late nineteenth-century Sweden are visible in contemporary attitudes to social deviants and nonconformists. In Swedish provincial cultures, narratives about local characters in the oral tradition played a significant part in regional identity formation in the n

We provide a simple set of rules for predicting interference effects in off-resonant transport through single molecule junctions. These effects fall into two classes, showing, respectively, an odd or an even number of nodes in the linear conductance within a given molecular charge state, and we demonstrate how to decide the interference class directly from the contacting geometry. For neutral alte

Objectives. Cirrhosis is a well-known risk factor for hepatocellular cancer, but the true risk in autoimmune hepatitis (AIH) is scarcely studied. Other cancers may arise after prolonged use of immune-modulating drugs. The aim of this study was to investigate the cancer risk in a large cohort of AIH patients. Material and methods. Six hundred and thirty-four Swedish patients in a well-defined cohor

Transcription factors involved in the specification and differentiation of neurons often continue to be expressed in the adult brain, but remarkably little is known about their late functions. Nurr1, one such transcription factor, is essential for early differentiation of midbrain dopamine (mDA) neurons but continues to be expressed into adulthood. In Parkinson's disease, Nurr1 expression is dimin

Background: A number of single nucleotide polymorphisms (SNPs) have been associated with broadband ultrasound attenuation (BUA) and speed of sound (SOS) as measured by quantitative ultrasound (QUS) at the calcaneus in the Framingham 100K genome-wide association study (GWAS) but have not been validated in independent studies. The aim of this analysis was to determine if these SNPs are associated wi

here have been few longitudinal studies on the effect of within-country mobility on patterns of mortality in deceased foreign-born individuals. The results have varied; some studies have found that individuals who move around within the same country have better health status than those who do not change their place of residence. Other studies have shown that changing one’s place of residence leads

The limiting accuracy for measuring the location of an optical image is set by diffraction and photon noise, i.e., by the dual wave-particle nature of light. A theoretical expression for the limiting accuracy is derived under idealized conditions and generalized to take into account more realistic circumstances, such as additive noise and finite pixel size. Its application is discussed in relation

Chronic neural interfaces that are both structurally and functionally stable inside the brain over long time periods and that have minimal effects on the physiological conditions of the neural tissue to be studied hold great promise to become invaluable research and clinical tool in the near future. In this chapter, I will briefly review the state of the art of neural interfaces and the concepts b

We propose an optical method for non-invasive characterisation of wood samples based on two optical techniques: time-resolved diffuse optical spectroscopy and gas in scattering media absorption spectroscopy. While the latter is sensitive to gases present inside wood pores, the former extracts information on the bulk material regarding light scattering and absorption. Measurements on spruce samples