Chronic exposure of pancreatic islets to elevated levels of palmitate leads to beta-cell dysfunction. We examined possible involvement of mitogenactivated protein kinases (MAPKs) and caspase-3 in palmitate-induced beta-cell dysfunction and tested the influence of the anti-diabetic drug rosiglitazone (ROZ). Palmitate amplified glucose-stimulated augmentation of intracellular free calcium ([Ca(2+)](

Recombinant human erythropoietins (rHuEPOs) are used to treat cancer-related anemia. Recent preclinical studies and clinical trials, however, have raised concerns about the potential tumor-promoting effects of these drugs. Because the clinical significance of erythropoietin receptor (EPOR) signaling in human non-small cell lung cancer (NSCLC) also remains controversial, our aim was to study whethe

The article deals with factors that can determine V°-to-I°-movement in Övdalian (älvdalska).

Purpose: Prostate specific antigen velocity has been proposed as a marker to aid in prostate cancer detection. We determined whether prostate specific antigen velocity could predict repeat biopsy results in men with persistently increased prostate specific antigen after initial negative biopsy. Materials and Methods: We identified 1,837 men who participated in the Goteborg or Rotterdam section of

We propose simple estimation of the location parameter for a density that is unbounded at the mode. The estimator maximizes a modified likelihood in which the singular term in the full likelihood is left out, whenever the parameter value approaches a neighborhood of the singularity location. The consistency and super-efficiency of this maximum leave-one-out likelihood estimator is shown through a

A novel technique for studying photon propagation in scattering media is proposed and demonstrated, as is believed, for the first time. Photons propagating through the medium, from a frequency-ramped single-mode diode laser, meet a reference beam from the same source, at a common detector, and beat frequencies corresponding to various temporal delays are observed by heterodyne techniques. Fourier

Proteins extracted from the seeds of Moringa trees are effective flocculents for particles dispersed in water and are attractive as a natural and sustainable product for use in water purification. Studies with a model system consisting of polystyrene latex particles have shown that the protein adsorbs to the surface and causes flocculation as unusually dense aggregates. Small-angle neutron scatter

We have investigated multiphoton multiple ionization of argon and xenon atoms at 5 keV using a new x-ray free electron laser (XFEL) facility, the SPring-8 Angstrom Compact free electron LAser (SACLA) in Japan. The experimental results are compared with the new theoretical results presented here. The absolute fluence of the XFEL pulse has been determined with the help of the calculations utilizing

The initial growth of MnBi on MnAs-terminated (GaMn)As is studied by means of synchrotron-based photoelectron spectroscopy. From analysis of surface core-level shifts we conclude that a continued epitaxial MnBi layer is formed, in which the MnAs/MnBi interface occurs between As and Bi atomic planes. The well-defined 1×2 surface reconstruction of the MnAs surface is preserved for up to 2 ML of MnBi

Digital subscriber lines (DSLs) technology is vastly used for high-speed data transmission. Crosstalk is one of the main problems in DSL. The research community has done extensive work on how to optimize spectrum allocation across DSL frequencies and mitigate crosstalk, a subject that has been called dynamic spectrum management (DSM). This text presents a novel DSM solution, referred to as semibli

Context: Scope management is a core part of software release management and often a key factor in releasing successful software products to the market. In a market-driven case, when only a few requirements are known a priori, the risk of overscoping may increase. Objective: This paper reports on findings from a case study aimed at understanding overscoping in large-scale, market-driven software dev

This paper presents the solution for optimization of the ALICE TPC readout for running at full energy in the Run2 period after 2014. For the data taking with heavy ion beams an event readout rate of 400 Hz with a low dead time is envisaged for the ALICE central barrel detectors during these three years. A new component, the Readout Control Unit 2 (RCU2), is being designed to increase the present r

A measurement of the W boson mass and width has been performed by the DELPHI collaboration using the data collected during the full LEP2 programme (1996-2000). The data sample has an integrated luminosity of 660 pb(-1) and was collected over a range of centre-of-mass energies from 161 to 209 GeV. Results are obtained by applying the method of direct reconstruction of the mass of the W from its dec