Triple-negative (TN) breast cancers (ER â ' PR â ' HER2 â ') are highly metastatic and associated with poor prognosis. Within this subtype, invasive, stroma-rich tumours with infiltration of inflammatory cells are even more aggressive. The effect of myeloid cells on reactive stroma formation in TN breast cancer is largely unknown. Here, we show that primary human monocytes have a survival advantag

Venous thromboembolism (VTE) is a relatively common cause of morbidity and mortality. It has an annual incidence of around 0.1- 0.3%. It is a multifactorial disease with many known risk factors, both transient and persistent. Among these, several genetic risk factors have been described. The most common genetic risk factor, factor V Leiden mutation in heterozygote form, is found in 5-8% of the Cau

Peatland net ecosystem production is a key variable to assess changes in the functional role of peatlands in the global carbon cycle. Light use efficiency (LUE) models in combination with satellite data have been used to estimate production for most major ecosystems, but peatlands have been largely ignored. The objectives of this study were: 1) to examine how the LUE parameter epsilon, ε (the amou

Background. Prevalence of childhood anxiety disorders at specific ages and genetic etiological influences on anxiety disorders in young children have been little studied. The present study reports prevalence estimates in a community sample of 6-year-old twins, and patterns of genetic and environmental influences on these early-onset anxiety disorders. Method. Using a two-phase design 4662 twin-pai

Background: From middle childhood onwards, substantial evidence points to phenotypic differentiation between anxiety diagnostic categories such as generalised anxiety, separation anxiety, specific phobia, and obsessive-compulsive disorders. However, little is known about the genetics of these categories and especially about the phenotypic and genetic structure of related behaviours in pre-school c

The Mississippi Scale for Combat-Related PTSD is widely used in the assessment of post-traumatic stress disorder (PTSD). The high face-validity of the scale may make it vulnerable to faking however. The present study found that the scores of individuals instructed to respond 'as if' they had PTSD did not differ from the scores of veterans with PTSD. Furthermore, although veterans who were diagnose

The ongoing climate change can influence the dynamic of insect populations and therefore the Insect species Responsible for Forest Damage (“insects-RFD” hereafter). The present study aims at identifying the most occurring insects-RFD in Sweden, and exploring the relationships between insects-RFD and climate and land management changes. The recorded insect attacks based on historical reports, liter

Aim: Changes in climate and land use practices have been found to affect animal populations in different parts of the world. These studies have typically been conducted during the breeding season, whereas the non-breeding season (hereafter ‘winter’) has received much less attention. Changes in regional winter abundances could be caused by changes in overall population sizes and/or redistribution o

Even though leukemia is considered to be confined to one specific hematopoietic cell type, cases of acute leukemia of ambiguous lineage and patients relapsing in phenotypically altered disease suggest that a malignant state may be transferred between lineages. Because B-cell leukemia is associated with mutations in transcription factors of importance for stable preservation of lineage identity, we

One hundred and thirty-four cases of Wolff-Parkinson-White syndrome were studied to evaluate the relative usefulness of electrocardiography (ECG), electrophysiological studies (EPS), body surface mapping (BSM), gated blood-pool phase analysis (nuclear studies), and vectorcardiography (VCG) in the localization of the accessory pathway (ACP). In comparison with the final localization verified by int

Objective There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity and breastfeeding practices with the incidence of CHD later in life among women in a large, pan-European cohort study. Methods Data were used from European Prospective Investigat

We propose a framework for calibration, positioningand tracking in a scene viewed by multiple cameras, througha flat refractive surface and one or several flat reflective walls.Refractions are explicitly modeled by Snell’s law and reflectionsare handled using virtual points. A novel bundle adjustmentframework is introduced for solving the nonlinear equationsof refractions and the linear equations

This article focuses on coordination between governance actors in higher education. The object of the study is a department at a public university, seen as a multi-project environment. The purpose of this article is to illustrate and analyze project governance as a tool that allows departmental management to coordinate with the authorities, the board and the management at different levels at the u

Inom fysiken används ofta hårda sfärer som modellsystem för att beskriva beteenden och strukturer hos grundläggande byggstenar såsom atomer och molekyler. Dessa sfärer kan ses som en samling biljardbollar och kan därav bara organiseras på ett begränsat antal sätt. Med den ökade förståelsen för många komplexa fysikaliska fenomen och den snabbt växande utvecklingen av nya material behövs modellsysteSoft and deformable ionic microgels such as poly(N-isopropylacrylamide-co-acrylic acid), PNIPAM-co-AA, microgels have shown to be a versatile alternative to the already well-established hard sphere model systems. Their tuneable interaction potential makes them well suited as model systems to study the phase behaviour found for particles interacting via a soft isotropic potential. This stems from t

In the aftermath of the Arab Spring, conflicts in Egypt and Tunisia over the authority to rule and the role of religion in society raised questions about these societies’ capacity for reconciling differences. In retrospect, the conflicts also raise questions about the theoretical tools used to analyse regional developments. In particular, the ‘post-Islamism’ thesis has significantly changed the de

Unveiling the determinants for transferase and hydrolase activity in glycoside hydrolases would allow using their vast diversity for creating novel transglycosylases, thereby unlocking an extensive toolbox for carbohydrate chemists. Three different amino acid substitutions at position 220 of a GH1 β-glucosidase from Thermotoga neapolitana caused an increase of the ratio of transglycosylation to hy

Fast substitution of chloride for bromide and iodide trans to triphenylsilyl in trans-PtCl(SiPh3)(PMe2Ph)2 has been studied by stopped-flow spectrophotometry in acetonitrile solution. Substitution is reversible with an observable solvent path via the solvento complex trans-[Pt(SiPh3)(MeCN)(PMe2Ph)2]+, which has also been synthesized and characterized in solution. Rate constants for the forward and