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A genome-wide association study in multiple system atrophy

Objective: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS). Methods: We performed a GWAS with >5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European center

The prognostic impact of COX-2 expression in breast cancer depends on oral contraceptive history, preoperative NSAID use, and tumor size

The association between tumor cyclooxygenase 2 (COX-2) expression and breast cancer prognosis has been inconsistent. The purpose of this study was to evaluate the prognostic significance of COX-2 tumor expression according to adjuvant treatment, and potential effect modifications of non-steroid anti-inflammatory drug (NSAID) use, and other tumor and lifestyle factors. A prospective cohort of 1,116

Helicity-dependent terahertz radiation from topological insulator Sb2Te3 thin film by femtosecond optical excitation

We report on terahertz radiation from topological insulator (TI) Sb2Te3 thin film under ultrafast optical excitation with different helicity. Polarity-reversals of the emitted THz radiation were observed as the helicity of optical pulses reversed. The observed phenomena are coincident with the characteristics of the helicity-dependent photocurrent on TIs. Our work demonstrates the potential applic

Improved Relay Autotuning using Normalized Time Delay

The relay autotuner provides a simple way offinding PID controllers of sufficient performance. By usingan asymmetric relay function the excitation of the process isimproved. This gives better models, and hence a better tuning,without increasing the time consumption or complexity of theexperiment. Some processes demand more accurate modelingand tuning to obtain controllers of sufficient performanceThe relay autotuner provides a simple way offinding PID controllers of sufficient performance. By usingan asymmetric relay function the excitation of the process isimproved. This gives better models, and hence a better tuning,without increasing the time consumption or complexity of theexperiment. Some processes demand more accurate modelingand tuning to obtain controllers of sufficient performance

Physical risk factors influencing wheeled mobility in children with cerebral palsy : A cross-sectional study

Background: There is a lack of understanding of the factors that influence independent mobility and participation in meaningful activities. The purpose of this study was to analyse physical factors influencing independent use of manual and power wheelchairs in a total population of children with cerebral palsy (CP). Methods: A cross-sectional study based on the most recent examination of all child

IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively

Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional dendritic cells (cDC1s) and remains highly expressed in differentiated DCs. Transcription factors that are required to maintain the identity of terminally differentiated cells are designated “terminal selectors.” Using BM chimeras, condit

Is nitric oxide (NO) produced by invertebrate neurons?

NADPH-DIAPHORASE (NADPHd) is known to be identical to nitric oxide (NO) synthase in the mammalian nervous system, and is therefore used as a marker of NO-producing neurones. Using the histochemical reaction for NADPHd, we searched for such neurones in a selection of invertebrates. Special emphasis was given to molluscs. No selective neuronal staining was found in representatives of coelenterates,

ANALYSIS OF CLUSTER OF DIFFERENTIATION (CD) MARKERS IN PEDIATRIC BRAIN TUMORS CAN BE USED AS A DIAGNOSTIC AND PROGNOSTIC TOOL

BACKGROUND: Malignant pediatric brain tumors constitute a heterogeneic group of central nervous system tumors, and general markers of diagnosis and prognosis are not available. Recently, a panel of CD markers (CD15, CD24, CD29) was used to define increasing neural differentiation of embryonic stem cells. Although these CD markers have been associated with worse prognosis due to presence of tumor p

Signed value of monophasic action potential duration difference. A useful measure in evaluation of dispersion of repolarization in patients with ventricular arrhythmias

AIMS: To evaluate the usefulness of the signed value of monophasic action potential duration difference in analysing the cause of dispersion of ventricular repolarization.METHODS AND RESULTS: Monophasic action potentials were simultaneously recorded from the right ventricular apex and outflow tract during programmed stimulation in 36 patients with ventricular arrhythmias. The time difference betwe

Electron dynamics in solar energy converting materials

Solar energy is the most abundant renewable energy source available. Conversion of light into electricity and chemical energy are the two major paths for solar energy conversion. Nanostructured organic and hybrid materials are being explored for applications in photovoltaic solar energy conversion, as well as photocatalysis for solar fuel generation. Light harvesting, energy transport, charge phot

Exocomet signatures around the A-shell star φ Leonis?

We present an intensive monitoring of high-resolution spectra of the Ca ii K line in the A7IV shell star φ Leo at very short (minutes, hours), short (night to night), and medium (weeks, months) timescales. The spectra show remarkable variable absorptions on timescales of hours, days, and months. The characteristics of these sporadic events are very similar to most that are observed toward the debr

Development and functional demonstration of a wireless intraoral inductive tongue computer interface for severely disabled persons

Purpose: Individuals with tetraplegia depend on alternative interfaces in order to control computers and other electronic equipment. Current interfaces are often limited in the number of available control commands, and may compromise the social identity of an individual due to their undesirable appearance. The purpose of this study was to implement an alternative computer interface, which was full

A public health perspective to environmental barriers and accessibility problems for senior citizens living in ordinary housing

Background: Housing environments that hinder performance of daily activities and impede participation in social life have negative health consequences particularly for the older segment of the population. From a public health perspective accessible housing that supports active and healthy ageing is therefore crucial. The objective of the present study was to make an inventory of environmental barr

Being a homebirth midwife in the Nordic countries - a phenomenological study

OBJECTIVE: To describe the lived experience of being a homebirth midwife in the Nordic countries.METHODS: Interviews conducted with 21 homebirth midwives from the five Nordic countries were analyzed with a phenomenological approach.RESULTS: The essential structure of being a homebirth midwife in the Nordic countries can be understood as realizing altruistic values and fulfilling one's own desires

A new time optimizing probabilistic load balancing algorithm in grid computing

The computing grid is a distributed parallel processing system that share and choosing resources dynamically and provide need of user operation power, cost and quality .grid management resources does as a diagnostic and assigning resources scheduling and resource monitoring in grid . Scheduling process directs tasks to suitable resources. It must take place some how that load work distributed equa

Effect of pentisomide (CM 7857) on myocardial excitation, conduction, repolarization, and refractoriness. An electrophysiological study in humans

The electrophysiological effects of pentisomide upon the intact human heart were evaluated using programmed stimulation and recording of intracardiac monophasic action potentials (MAP) in 17 patients with various ventricular arrhythmias. After i.v. administration of pentisomide, 85-135 mg, the atrial-His interval increased by 8 +/- 12 ms (p less than 0.05) during sinus rhythm and by 13 +/- 21 ms (

The association between sleep duration, insulin sensitivity, and β-cell function : The EGIR-RISC study

Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing. Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in th