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Cambodia in 2022 was at the crossroads of the past and the future. Preparations were under way for the imminent power handover to a new generation of Cambodian People’s Party (CPP) leaders, most of whom are scions of the incumbent government. The era of the military fighter generation of CPP leaders led by Prime Minister Hun Sen was drawing to an end, which necessitated the reflection on and the c
Background: Bioactive adrenomedullin (bio-ADM) is a vasoactive peptide with a key role in reducing vascular hyperpermeability and improving endothelial stability during infection, but it also has vasodilatory properties. Bioactive ADM has not been studied in conjunction with acute respiratory distress syndrome (ARDS), but it has recently been shown to correlate with outcomes after severe COVID-19.
Background: A prediction model that estimates survival and neurological outcome in out-of-hospital cardiac arrest patients has the potential to improve clinical management in emergency rooms. Methods: We used the Swedish Registry for Cardiopulmonary Resuscitation to study all out-of-hospital cardiac arrest (OHCA) cases in Sweden from 2010 to 2020. We had 393 candidate predictors describing the cir
Traditional agricultural or eco-hydrological models usually ignore soil deformation and its impact on hydrothermal properties when simulating soil water, heat, and salt transport under freeze–thaw conditions. As a result, significant errors may occur when these models are used in areas with considerable frost heave, such as arid areas with shallow groundwater tables. In this study, the simultaneou
Climate change has caused significant impacts on water resource redistribution around the world and posed a great threat in the last several decades due to intensive human activities. The impacts of human water use and management on regional water resources remain unclear as they are intertwined with the impacts of climate change. In this study, we disentangled the impact of climate-induced human
OBJECTIVE: Prior studies have reported that heart failure typically affects elderly, multimorbid and socioeconomically deprived men. Women with heart failure are generally older, have a higher EF (ejection fraction) and have more heart failure-related symptoms than men. This study explored the disparities in the prevalence of heart failure between men and women in relation to age, multimorbidity l
Accurate evapotranspiration (ET) data are required for many hydro-meteorological applications. Compared with the traditional evaluation that requires in-situ measurements, the triple collocation (TC) technique estimates geophysical product errors without the need for ground truth, which is especially suitable over large areas lacking a dense in-situ network. However, violations of the zero-error c
Increased shale gas extraction through hydraulic fracturing and its distribution through shale gas pipelines have brought about innumerable socioeconomic consequences, both tangibly and intangibly. Evidence remains unclear on what are the impacts of shale gas developments on property values. By employing a mixed method approach, combining original data collected in the Marcellus Shale through inte
West Virginia, sitting fully in the eastern US region of Appalachia, has a long history of resource extraction, including salt, timber, coal and oil. In the late 2000s, gas became another popular resource, obtained through hydraulic fracturing. The once-hilly landscape has been flattened, valleys have been filled, and caves have been dug all because of extraction. In this photo essay we document t
Photovoice is an increasingly popular research method across disciplines due to its flexibility and capacity for generating rich data. This article argues that while its practical virtues are abundant, the theoretical contributions of photovoice to qualitative research are just as important. We argue that photographs can act as boundary objects that enable collective sensemaking at multiple stages
What is the level of state capacity in developing countries today, and what have been its drivers over the past century? We construct a comprehensive new data set of tax and revenue collection for forty-six African polities from 1900 to 2015. Our data show that polities in Africa have been characterized by strong growth in fiscal capacity on average, but that substantial heterogeneity exists. The
Background: Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast. Current ihMT acquisitions utilise fast Gradient Echo sequences which are among the most acoustically noisy MRI sequences, reducing patient comfort during acquisition. We sought to address this by modifying a near silent MRI sequence to include ihMT contrast. M
Large amounts of germline sequencing data have recently become available and we sought to compare these results with population-based family history data. Family studies are able to describe aggregation of any defined cancers in families. The Swedish Family-Cancer Database is the largest of its kind in the world, covering the Swedish families through nearly a century with all cancers in family mem
Background: Patients with obesity have a higher risk of complications after total knee arthroplasty (TKA). We investigated the change in weight 1 and 2 years post-Bariatric Surgery (BS) in patients that had undergone both TKA and BS as well as the risk of revision after TKA based on if BS was performed before or after the TKA. Methods: Patients who had undergone BS within 2 years before or after T
Evidence of air pollution exposure, namely, ambient particulate matter (PM), during pregnancy and an increased risk of autism in children is growing; however, the unique PM sources that contribute to this association are currently unknown. The aim of the present study was to investigate local, source-specific ambient PM exposure during pregnancy and its associations with childhood autism, specific
Background: Molecular analyses have shown that tumours diagnosed as supratentorial primitive neuro-ectodermal tumours of the central nervous system (CNS-PNETs) in the past represent a heterogenous group of rare childhood tumours including high-grade gliomas (HGG), ependymomas, atypical teratoid/rhabdoid tumours (AT/RT), CNS neuroblastoma with forkhead box R2 (FOXR2) activation and embryonal tumour
The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases. Here, we identify SOX11 as a dependency transcription factor in adrenergic neuroblastoma based on recurrent chromosome 2p focal gains and amplifications, specific expression in the normal sympatho-adrenal lineage and adrenergic neuroblastoma,
