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Objectives: Cigarette smoke, a strong risk factor for cardiovascular diseases, upregulates contractile endothelin (ET) receptors in coronary arteries. The present study examined the effects of second hand cigarette smoke exposure on the contractile endothelin receptors and the role of the MEK1/2 pathway in rat coronary arteries. Design: Rats were exposed to secondhand smoke (SHS) for 8 weeks follo
In addition to being interesting in itself, the photon-photon interactions will be an inevitable background for the future electron-positron colliders. Thus to be able to quantify the potential of future electron-positron colliders it is important to have an accurate description of these collisions. Here we present our ongoing work to implement the photon-photon collisions in the Pythia 8 event ge
Legal pluralism provided a useful alternative framework because pluralism had always sought to identify hybrid legal spaces, where multiple normative systems occupied the same social field. An emphasis on legal pluralism also freed scholars from endless intractable debates about whether international law is truly law given that coercive enforcement power in the international and transnational aren
The MAX IV facility in Lund, Sweden consists of two storage rings for production of synchrotron radiation, and a short-pulse-facility (SPF). The two rings are designed for 3 GeV and 1.5 GeV, respectively, where the initial beam commissioning of the former has recently been completed, and commissioning of the latter was started in September 2016. Both rings will be operating with top-up injections
Introduction: Universal screening for preterm delivery by adding transvaginal ultrasound measurement of cervical length to routine second trimester ultrasound has been proposed. The aim is to estimate inter- and intraobserver agreement and reliability of second trimester transvaginal ultrasound measurements of cervical length performed by specially trained midwife sonographers. Material and method
The European Spallation Source requires a pulsed linac with an average beam power on the target of 5 MW, which is about five times higher than the most powerful spallation source in operation today. Over 97 % of the acceleration occurs in superconducting cavities. ESS will be the first accelerator to employ double spoke cavities to accelerate beam. Accelerating gradients of 9 MV/meter is required
The graptolite biostratigraphy of the 116.11-m-long Röstånga-2 drill core from Scania, southern Sweden, includes the Darriwilian (Middle Ordovician) Holmograptus lentus, Nicholsonograptus fasciculatus, Pterograptus elegans, Pseudamplexograptus distichus and Jiangxigraptus vagus biozones, and the lower Sandbian (Upper Ordovician) Nemagraptus gracilis Biozone. The early Darriwilian Komstad Limestone
This chapter deals with the significance of the thing as the outcome of labour. In terms of product design, at first a division of labour with manufacture was maintained. The design in a product has somewhat of an imperative power, yet it is has to be reconfigured to become aware. The projects were longitudinal, development project in retail chains in Norway. Even though many professions are engag
The ESS elliptical superconducting Linac consists of two types of 704.42 MHz cavities, medium and high beta, to accelerate the beam from 216 MeV (spoke cavity Linac) up to the final energy of 2 GeV. The last Linac optimization, called Optimus+ [1], has been carried out taking into account the limitations of SRF cavity performance (field emission). The medium and high-beta parts of the Linac are co
År 1919 reste astronomer söderut för att fånga en solförmörkelse och bekräfta Einsteins allmänna relativitetsteori.In 1919 astronomers journeyed south to catch a solar eclipse and to check up on Einsteins theory of general relativity.
This chapter describes a protocol for the separation of different cell fractions from Streptococcus pyogenes and sample preparation for analysis by mass spectrometry. The presented approach can be used for the analysis of all subcellular proteomes from S. pyogenes and enables identification of drug or vaccine targets within a certain cellular fraction. Here, proteins integral to the plasma membran
BACKGROUND: Over the past decades many regions have experienced a steady increase in the incidence of cutaneous melanoma. Here, we report on incidence trends for subsequent primary melanoma.METHODS: In this nationwide population-based study, patients diagnosed with a first primary cutaneous melanoma reported to the Swedish Cancer Registry, were followed for up to ten years for a diagnosis of subse
In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13 germline mutations and breast cancer risk in a previous study consisting of 3,270 familial non-BRCA1/2 breast ca
Purpose: Radiation therapy (RT) after breast-conserving surgery reduces locoregional recurrences and improves survival but may cause late side effects. The main purpose of this paper was to investigate long-term side effects after whole breast RT in a randomized clinical trial initiated in 1991 and to report dose-volume data based on individual 3-dimensional treatment plans for organs at risk. Met
The fitting attitude analysis of value states that for objects to have value is for them to be the fitting targets of attitudes. Good objects are the fitting targets of positive attitudes, while bad objects are the fitting targets of negative attitudes. The following paper presents an argument to the effect that value and the fittingness of attitudes differ in terms of their explanations. Whereas
The article analyses recent public initiatives to memorialise the establishment of India and Pakistan as postcolonial states in terms of violent partitioning rather than as a successful act of independence from British imperialism. The twin focal points of the article are the Partition Museum in Amritsar and the online 1947 Partition Archive. Both of these subscribe to and further the view that di
Pathogen-mediated balancing selection is commonly considered to play an important role in the maintenance of genetic diversity, in particular in immune genes. However, the factors that may influence which immune genes are the targets of such selection are largely unknown. To address this, here we focus on Pattern Recognition Receptor (PRR) signalling pathways, which play a key role in innate immun
This paper presents a topology optimization framework for designing periodic viscoplastic microstructures under finite deformation. To demonstrate the framework, microstructures with tailored macroscopic mechanical properties, e.g., maximum viscoplastic energy absorption and prescribed zero contraction, are designed. The simulated macroscopic properties are obtained via homogenization wherein the
We investigate the techniques and ideas used in Shefi and Teboulle (SIAM J Optim 24(1), 269–297, 2014) in the convergence analysis of two proximal ADMM algorithms for solving convex optimization problems involving compositions with linear operators. Besides this, we formulate a variant of the ADMM algorithm that is able to handle convex optimization problems involving an additional smooth function
