Background: Systematic reviews comparing untargeted antifungal treatment with placebo or no treatment in critically ill patients have provided conflicting results. We aimed to assess patient-important benefits and harms of untargeted antifungal therapy vs. placebo or no treatment in adult patients with complicated intra-abdominal infection. Methods: We conducted a systematic review with meta-analy

In the last couple of decades, countries have enacted new laws concerning environmental pollution caused by heavy-duty commercial and passenger vehicles. This is done mainly in an effort to reduce smog and health impacts caused by the different pollutions. One of the legislated pollutions, among a wide range of regulated pollutions, is nitrogen oxides (commonly abbreviated as NOx). The SCR (SelectIn the last couple of decades, countries have enacted new laws concerning environmental pollution caused by heavy-duty commercial and passenger vehicles. This is done mainly in an effort to reduce smog and health impacts caused by the different pollutions. One of the legislated pollutions, among a wide range of regulated pollutions, is nitrogen oxides (commonly abbreviated as NOx). The SCR (Select

Renal cell carcinoma (RCC), arising from the proximal tubule in the kidney, accounts for approximately 85% of kidney cancers and causes over 140,000 annual deaths worldwide. In the last decade, several new therapies have been identified for treatment of metastatic RCC. Although these therapies increase survival time compared to standard care, none of them has curative properties. The nephrotoxin o

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that affects many different organ systems, with excessive production of type I interferons (IFNs) and autoantibodies against nucleic acids as hallmarks. Activation of the type I IFN system in SLE is due to continuous stimulation of plasmacytoid dendritic cells by endogenous nucleic acids, leading to sustained type I IF

Engine efficiency is often controlled in an indirect way through combustion timing control. This requires a priori knowledge of where to phase the combustion for different operating points and conditions. With cylinder individual efficiency estimation, control strategies aiming directly at fuel consumption optimization can be developed. It has previously been shown that indicated efficiency can beEngine efficiency is often controlled in an indirectway through combustion timing control. This requires a prioriknowledge of where to phase the combustion for differentoperating points and conditions. With cylinder individual efficiencyestimation, control strategies aiming directly at fuelconsumption optimization can be developed. It has previouslybeen shown that indicated efficiency can be estim

Student engagement is an important factor when it comes to the learning process. Students who do not feel engaged in their studies risk surface learning, are more likely to fail their exams and might even drop out of their education. The teaching community has tried different methods in order to increase student engagement. One of them is the Contributing Student Pedagogy (CSP), where students con

The reflective processes in which supervisors and doctoral students indulge together may be improvisatory to an important extent. Based on a literature review and a small interview study, I argue that there are important similarities between musical improvisation and supervision dialogue regarding, for instance, the need for structure as well as continuous impulse fluidity, and the need for recept

"On the Dragon or Lindworm" was first published by Swedish ethnologist Gunnar Olof Hyltén-Cavallius in 1884, and in a second edition in 1885. This third edition includes the whole original text, with 48 accounts by people who claim having seen and in some cases even killed huge snakes called dragons or lindworms. Thomas Malm (herpetologist and human ecologist) has added an introduction, notes, ill

Here we describe the parametric response map (PRM), a voxel-wise approach for image analysis and quantification of hemodynamic alterations during treatment for 44 patients with high-grade glioma. Relative cerebral blood volume (rCBV) and flow (rCBF) maps were acquired before treatment and after 1 and 3 weeks of therapy. We compared the standard approach using region-of-interest analysis for change

The UK Government’s proposal that the Charter of Fundamental Rights of the EU (the Charter) will not be converted into UK law following Brexit (clause 5(4) of the EU Withdrawal Bill) has generated strong reaction from opposition parties. The Labour party has indicated that it considers this to be a ‘red-line’ issue, and that it will not support a bill that does not incorporate the charter into UK