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Bridging the macro and the micro by considering the meso: reflections on the fractal nature of resilience

We pursued the following three interconnected points: (1) there are unexplored opportunities for resilience scholars from different disciplines to cross-inspire and inform, (2) a systems perspective may enhance understanding of human resilience in health and social settings, and (3) resilience is often considered to be fractal, i.e., a phenomenon with recognizable or recurring features at a variet

Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis.

Copper homeostasis is important for virulence of the fungus Cryptococcus neoformans, which can cause lethal meningoencephalitis in humans. Cryptococcus cells encounter high copper levels in the lung, where infection is initiated, and low copper levels in the brain. Here we demonstrate that two Cryptococcus copper transporters, Ctr1 and Ctr4, differentially influence fungal survival during pulmonar

Verifying Fire Safety Design in Sprinklered Buildings

This report contains a verification method that could be applied when evaluating trail fire safety design in a performance-based code environment. The report is focused on design alternatives (i.e. design alternatives) where fire sprinkler systems have an important role. Three possible verification methods are proposed together with the procedure on how they could be applied in design. The covered

A comparative study of digital human modelling simulation results and their outcomes in reality: A case study within manual assembly of automobiles

The objective of this study was to examine to what extent ergonomics simulations of manual assembly tasks correctly predict the real outcomes in the plants and if recommended measures originating from ergonomics simulations are taken into consideration. 155 ergonomics simulation cases were used in the study and all cases were performed by nine simulation engineers at Volvo Car Corporation in Gothe

Environmental forcing and genetic differentiation in subdivided populations

Questions: How will genetic differentiation and genetic drift in spatially structured populations be affected by different classes of autocorrelated environmental noise? How does dispersal interact with fluctuations generated from the demographic and environmental forcing in shaping the neutral genetic patterns? Model and key assumptions: Populations are regulated locally by density-dependent feed

EULAR points to consider for conducting clinical trials in systemic lupus erythematosus

Objective: Systemic lupus erythematosus (SLE) is a complex multi-organ disease, characterised by relapses and remissions. Designing a high-quality randomised controlled trial poses many challenges. We have developed evidenced-based recommendations for points to consider in conducting clinical trials in patients with SLE. Methods: The EULAR Task Force on SLE comprised 19 specialists and a clinical

Applying measures of discriminatory accuracy to revisit traditional risk factors for being small for gestational age in Sweden: a national cross-sectional study.

Small for gestational age (SGA) is considered as an indicator of intrauterine growth restriction, and multiple maternal and newborn characteristics have been identified as risk factors for SGA. This knowledge is mainly based on measures of average association (ie, OR) that quantify differences in average risk between exposed and unexposed groups. Nevertheless, average associations do not assess th

Antenna Bandwidth Optimization by Genetic Algorithms with Single Frequency Simulation

Antenna Q optimization by a genetic algorithm with method of moments simulation at a single frequency is described. The optimized antennas may have arbitrary shapes within a rectangular region. Simulations using a commercial tool show good agreement between the predicted and realized Q factor. Furthermore, comparison with the physical bound shows that the optimized antennas perform close to the op

Usefulness of computed tomography linear measurements in diagnosing Alzheimer's disease.

Background: Medial temporal lobe atrophy (MTA) is an early sign of Alzheimer's disease (AD). The current method of choice for measuring MTA is volumetric measurement based on 3D magnetic resonance imaging (MRI), but this complicated method has not been implemented clinically. Purpose: To investigate whether simple computed tomography (CT) linear measurements of the brain could be of value in AD wo

Vibration thresholds are increased at low frequencies in the sole of the foot in diabetes a novel multi-frequency approach.

AIMS: To evaluate multi-frequency tactilometry as a method to measure vibrotactile sense in the sole of the foot in subjects with diabetes. METHODS: Vibration thresholds were investigated at five frequencies (8, 16, 32, 64 and 125 Hz) at three sites (first and fifth metatarsal heads and heel) in the sole of the foot in subjects with Type 1 and Type 2 diabetes (n = 37). Thresholds were compared wit

Electroencephalography for neurological prognostication after cardiac arrest

Popular Abstract in Swedish Hjärt-kärlsjukdom är en av västvärldens stora folksjukdomar. I Sverige drabbas årligen cirka 10 000 personer av plötsligt hjärtstopp. Den vanligaste orsaken är att en akut hjärtinfarkt orsakar ett ”elektriskt kaos” i hjärtat. Vid ett hjärtstopp upphör blodförsörjningen till hjärnan, vilket leder till medvetslöshet inom några sekunder och inom några få minuter börjar hjäThis thesis focuses on the prognostic value of electroencephalography(EEG) in comatose patients resuscitated after cardiac arrest (CA), using both simplified continuous EEG monitoring (cEEG) and routine EEG. Background: Comatose survivors are admitted to an intensive care unit (ICU) to support vital functions. Postresuscitation care includes target temperature management (TTM) for 24 hours. The d

A tale of the tall : A short report on stature in Late Neolithic–Early Bronze Age southern Scandinavia

Human stature as a measurement for evaluating physical status is used by the World Health Organiza-tion (WHO) as well as bioarchaeologists. The reason for this is that only about 80% depends on genetic factors, while 20% depend on the environment. Bad living conditions decrease stature in a population. This paper aims to make a short review of earlier reports on stature in Late Neolithic–Early Bro

Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae).

Marine microbial protists, in particular, dinoflagellates, produce polyketide toxins with ecosystem-wide and human health impacts. Species of Gambierdiscus produce the polyether ladder compounds ciguatoxins and maitotoxins, which can lead to ciguatera fish poisoning, a serious human illness associated with reef fish consumption. Genes associated with the biosynthesis of polyether ladder compounds