Endothelial cells release ATP in response to fluid shear stress, which activates purinergic (P2) receptor-mediated signaling molecules including endothelial nitric oxide (eNOS), a regulator of vascular tone. While P2 receptor-mediated signaling in the vasculature is well studied, the role of P2Y2 receptors in shear stress-associated endothelial cell alignment, cytoskeletal alterations, and wound r

For the purpose of this paper, Erbil city, located in the northern part of Iraq, has been chosen as a representative case study for a large number of cities, particularly in semi-arid areas, lacking sustainable drainage systems (SuDS). The study assesses (a) the role of SuDS as a measure in areas with a water shortage; (b) water scarcity in decision-making processes; (c) the lack of legislation to

Stoichiometric and very rich (1.5 ≤ ɸ ≤ 1.9) laminar flat flames of methane have been investigated using nonintrusive laser diagnostics. Premixed CH4 + O2 + N2 flames were stabilized at a pressure of 30 ± 0.3 Torr. Temperature profiles were obtained using laser-induced fluorescence of OH. Absolute concentration profiles of singlet methylene, 1CH2, were measured by intracavity laser absorption spec

Objectives To assess how suitable current chronic obstructive pulmonary disease (COPD) cost-effectiveness models are to evaluate personalized treatment options for COPD by exploring the type of heterogeneity included in current models and by validating outcomes for subgroups of patients. Methods A consortium of COPD modeling groups completed three tasks. First, they reported all patient characteri

Mitochondria are essential for early cardiac development and impaired regulation of mitochondrial function was implicated in congenital heart diseases. We described a newborn girl with hypertrophic cardiomyopathy and profound hearing loss. The mtDNA mutational analysis revealed the presence of known polymorphisms associated to cardiomyopathy and/or hearing loss, and 2 novel heteroplasmic mutations

Outdoor lighting makes public space accessible after dark and aims to improve the safety of pedestrians. A systematic literature review shows that facial recognition is the most relevant visual task for judging the potential threat of other pedestrians. In the identified literature it has been operationalized as the task of recognising gender; guessing identity or seeing facial features. However,

Inflammation and neurodegeneration characterize multiple sclerosis, as well as many other diseases of the central nervous system (CNS). The understanding of the molecular pathways that regulate these processes is of fundamental importance for the development of new therapies. Nerve lesions paradigms in animals can serve as important tools to dissect central features of human CNS disease and by usi

Purpose: The purpose of this paper is to contribute to a more complete understanding of logistics preparedness. By comparing extant research in preparedness and logistics with findings from empirical analysis of secondary data, the authors develop a definition of and framework for logistics preparedness, along with suggestions for future research agenda. Design/methodology/approach: The authors li

Nocturnal insects have evolved remarkable visual capacities, despite small eyes and tiny brains. They can see colour, control flight and land, react to faint movements in their environment, navigate using dim celestial cues and find their way home after a long and tortuous foraging trip using learned visual landmarks. These impressive visual abilities occur at light levels when only a trickle of p

Historical documents record the operation of a silver mine from the 16th century AD located near the former village of Salberget in central Sweden. The historical record describes several categories of inhabitants, including local families, workers and miners, foreign engineers and mining specialists, as well as war captives and criminals used as forced labor in the mines. A church yard in the vic

We obtain a sharp norm estimate for Hankel operators with anti-analytic symbol for weighted Bergman spaces. For the classical Bergman space, the estimate improves the corresponding classical Putnam inequality for commutators of Toeplitz operators with analytic symbol by a factor of 1/2, answering a recent conjecture by Bell, Ferguson and Lundberg. As an application, this yields a new proof of the

Solar energy is considered to be an alternative sustainable energy source in the urban environment. The potential of using solar energy in urban areas is highly dependent on urban morphology which affects the level of solar irradiance received by individual buildings. Many studies focus on solar energy potential of building form in urban areas but relatively few studies examine how urban morpholog

Gasoline partially premixed combustion (PPC) is a potential strategy to achieve high engine efficiency, as well as low NOx and soot emissions. But the in-cylinder combustion process of PPC is not well understood. In this paper, multiple optical diagnostics are applied to investigate the PPC ignition and flame development in a light-duty optical engine under single-injection condition. For the inje

Aim To investigate the association of temperature on arrival to hospital after out-of-hospital-cardiac arrest (OHCA) with the primary outcome of mortality, in the targeted temperature management (TTM) trial. Methods The TTM trial randomized 939 patients to TTM at 33 or 36 °C for 24 h. Patients were categorized according to their recorded body temperature on arrival and also categorized to groups o

The aim of this study was to further investigate the psychometric properties (with focus on construct validity and scale function) of the Swedish version of the Person-centred Care Assessment Tool (P-CAT) in a sample consisting of staff working in elderly care units (N = 142). The aim was also to further develop and psychometrically test a modified, noncontext-specific version of the instrument (m

This study analyses psychological an tecedents of feelings of fear of wolves in a proportional sample of the Swedish population ( national sample, n = 545) andin a sample of people in c ounties with wolf presence (regi onal sample, n = 1,892). Structural equation model-ling of survey data suggests a dual pathway to self-re porte d fear. One path encompa sses the appraisal of the environmental cont