Sökresultat

Filtyp

Din sökning på "*" gav 526767 sökträffar

Children's attention to online adverts is related to low-level saliency factors and individual level of gaze control

Twenty-six children in 3rd grade were observed while surfing freely on their favourite websites. Eye movement data were recorded, as well as synchronized screen recordings. Each online advert was analyzed in order to quantify low-level saliency features, such as motion, luminance and edge density. The eye movement data were used to register if the children had attended to the online adverts. A mix

Flavonoids as inhibitors of human carbonyl reductase 1

Human carbonyl reductase 1 (CBR1), that is one of the enzymes responsible for the reduced efficiency of treatments by the antineoplastic agents anthracyclines, was functionally expressed in Saccharomyces cerevisiae. CBR1 was purified and kinetically characterised using daunorubicin as substrate. CBR1-catalysed reduction of daunorubicin followed an apparent Michaelis-Menten kinetics with K-M = 85.2

Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors

Background Numerous subsets of patients with chronic lymphocytic leukemia display similar immunoglobulin gene usage with almost identical complementarity determining region 3 sequences. Among IGHV4-34 cases, two such subsets with "stereotyped" B-cell receptors were recently identified, i.e. subset #4 (IGHV4-34/IGKV2-30) and subset #16 (IGHV4-34/IGKV3-20). Subset #4 patients appear to share biologi

A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail

Background: Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a major cause of death in Africa. It's resistance to most of the current drugs accentuates the pressing need for new chemotherapies. Polyamine metabolism of the parasite is distinct from the human pathway making it an attractive target for chemotherapeutic development. Plasmodium falciparum spermidin

Decrease by 50% of plasma IgA tissue transglutaminase antibody concentrations within 2 months after start of gluten-free diet in children with celiac disease used as a confirming diagnostic test.

Background Histological examination of small bowel biopsies is normally the gold standard for the diagnosis of celiac disease (CD). The objective of this study was to investigate whether the rate of decreases in elevated plasma IgA tissue transglutaminase antibody (IgA-tTG) and/or IgG deamidated gliadin peptides antibody (IgG - DGP) concentrations could be used as a confirming test for CD in child

From Trade Preferences to Trade Facilitation: Taking Stock of the Issues

The objective of the paper is to explore and give an overview of two central policy alternatives to improve the integration between the European Union and developing countries by removing barriers to trade: trade preferences and trade facilitation. The author reviews the relevant literatures and discusses the issues which constitute problems or opportunities for practitioners and researchers in bo

Neuroplasticity and neurorestoration in the treatment of Parkinson's Disease: Experimental studies in the mouse

Popular Abstract in English Neuroplasticity is the brain´s capacity to respond to inner and outer challenges with functional and structural reorganizations. An aberrant activation of neuroplasticity pathways may contribute to the development of neurological disease. In the case of Parkinson’s disease (PD), the induction of motor complications by L-DOPA pharmacotherapy is generally regarded as an eNeuroplasticity is the brain´s capacity to respond to inner and outer challenges with functional and structural reorganizations. An aberrant activation of neuroplasticity pathways may contribute to the development of neurological disease. In the case of Parkinson’s disease (PD), the induction of motor complications by L-DOPA pharmacotherapy is generally regarded as an example of maladaptive plasti

Psychosocial factors and attendance at a population-based mammography screening program in a cohort of Swedish women

Background: A better understanding of the factors that influence mammography screening attendance is needed to improve the effectiveness of these screening programs. The objective of the study was to examine whether psychosocial factors predicted attendance at a population-based invitational mammography screening program. Methods: Data on cohabitation, social network/support, sense of control, and

Do parental heights influence pregnancy length?: a population-based prospective study, HUNT 2

Background: The objective of this study was to examine the association of maternal and paternal height with pregnancy length, and with the risk of pre- and post-term birth. In addition we aimed to study whether cardiovascular risk factors could explain possible associations. Methods: Parents who participated in the Nord-Trondelag Health Study (HUNT 2; 1995-1997) were linked to offspring data from

Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma.

Survival following a diagnosis of multiple myeloma (MM) varies between patients and some of these differences may be a consequence of inherited genetic variation. In this study, to identify genetic markers associated with MM overall survival (MM-OS), we conduct a meta-analysis of four patient series of European ancestry, totalling 3,256 patients with 1,200 MM-associated deaths. Each series is geno

Determinants for Membrane Fusion Induced by Cholesterol-Modified DNA Zippers.

Intracellular membrane fusion is coordinated by membrane-anchored fusion proteins. The cytosolic domains of these proteins form a specific complex that pulls the membranes into close proximity. Although some results indicate that membrane merger can be accomplished solely on the basis of proximity, others emphasize the importance of bilayer stress exerted by transmembrane peptides. In a reductioni

Negotiating Thainess : Religious and National Identities in Thailand's Southern Conflict

The purpose of this study is to investigate how people express religious and national identities in the conflict-ridden Patani region of southern Thailand. In a historical framework of disputes over territory and political legitimacy, where identities have developed in response to an emerging Thai nation, it is of relevance to understand the dynamics of these identities and to disclose how local p

EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis

Objective To develop evidence-based recommendations for the diagnosis of knee osteoarthritis (OA). Methods The multidisciplinary guideline development group, representing 12 European countries, generated 10 key propositions regarding diagnosis using a Delphi consensus approach. For each recommendation, research evidence was searched systematically. Whenever possible, the sensitivity, specificity a

Ljudmiljö, hälsa och stadsbyggnad

Texter om Ljudmiljö, hälsa och stadsbyggnad av Björn Hellström, Gunnar Cerwén, Patrik Grahn, Peter Währborg, Jacob Kreutzfeldt, Jonas Björk, Jonathan Stoltz m.fl. Förord av Erik Skärbäck

Coordinated unbundling: A way to stimulate entrepreneurship through public procurement for innovation

Public procurement for innovation is a matter of using public demand to trigger innovation. Empirical studies have demonstrated that demand-based policy instruments can be considered to be a powerful tool in stimulating innovative processes among existing firms. However, the existing literature has not focused on the role this policy instrument can play in the promotion of (knowledge-intensive) en

Measuring Electoral Systems

This article compares and assesses four freely available cross-sectional time-series data sets in terms of their information on ballot structure, district structure, and formula of the electoral system in use for lower house and, if relevant, upper house and presidential elections. The authors find that the choice of data source matters for conclusions drawn on the consequences of electoral system