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Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized p

AIMS: This post hoc analysis of the ATHENA trial (NCT00174785) assessed the effect of dronedarone on the estimated burden of atrial fibrillation (AF)/atrial flutter (AFL) progression to presumed permanent AF/AFL, and regression to sinus rhythm (SR), compared with placebo. METHODS AND RESULTS: The burden of AF/AFL was estimated by a modified Rosendaal method using available electrocardiograms (ECG)

Background and aims: The lockdown of sports and gambling venues during the coronavirus disease 2019 (COVID-19) pandemic caused a fear of increased gambling on other online gambling types, with a risk for transfer to more addictive gambling than otherwise. This study aimed to estimate changes in gambling activity during COVID-19-affected periods among all gamblers at a Swedish state-owned gambling

Communication between sound and music experts is based on the shared understanding of a metaphorical vocabulary derived from other sensory modalities. Yet, the impact of sound expertise on the mental representation of these sound concepts remains blurry. To address this issue, we investigated the acoustic portraits of four metaphorical sound concepts (brightness, warmth, roundness, and roughness)

Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based vaccines are easier and cheaper to produce and do not require special storage/transportation conditions, they are suitable for low-/middle-income countries. Here, we report our vaccine development studies with the receptor binding domain of the SARS-CoV-2 Delta Plus strain (RBD-DP

Showing of two installations that result from an ecological sound art practice and its complex and radical modulation of performing/composing/curating within assemblages. The works spring out of an ecological-enactive approach, where through relational technique and fleshy listening the authors explore what the performative body can do; what connections and networks it creates across temporality a

—We exploit exogenous variation arising from the historical roll-out of the Swedish railroad network across municipalities to identify the impacts of improved transport infrastructure on innovative activity. A network connection led to a local surge in patenting due to an increased entry and productivity of inventors. As the railroad network expanded, inventors in connected areas began to develop

Context. Until now, heavy interstellar extinction has meant that only a few studies of chemical abundances have been possible in the inner Galactic bulge. However, it is crucial to learn more about this structure in order to better understand the formation and evolution of the centre of the Galaxy and galaxies in general. Aims. In this paper, we aim to derive high-precision α-element abundances us

Modeling inland water quality by remote sensing has already demonstrated its capacity to make accurate predictions. However, limitations still exist for applicability in diverse regions, as well as to retrieve non-optically active parameters (nOAC). Models are usually trained only with water samples from individual or local groups of waterbodies, which limits their capacity and accuracy in predict

BACKGROUND: The Scandinavian Diverticulitis (SCANDIV) trial and the LOLA arm of the LADIES trial randomized patients with Hinchey III perforated diverticulitis to laparoscopic peritoneal lavage or sigmoid resection. The aim of this analysis was to identify risk factors for treatment failure in patients with Hinchey III perforated diverticulitis.METHODS: This was a post hoc analysis of the SCANDIV

Recension av Mattias Legnérs bok

The pre-activation negativity (PrAN) is an event-related potential (ERP) component indexing how constraining phonological cues are. It has an early phase (136-200 ms), with sources in the left auditory cortices, and a late phase (200 ms onwards), with sources in Broca’s area. The PrAN has been found for segmental and prosodic cues increasing the certainty about upcoming words, morphemes, grammatic

With only a few exceptions, the historical study of individual-level correlates of child mortality in the United States has been limited to the period surrounding the turn of the twentieth century, when children ever born and children surviving data collected by the 1900 and 1910 censuses allow indirect estimation of child mortality. The recent release of linked census data, such as the IPUMS MLP

2021 marked the 30-year anniversary of the publication Fatal Years: Child Mortality in the late Nineteenth-Century United States, a pioneering work in historical demography by Samuel H. Preston and Michael R. Haines. This special issue showcases the current state of historical mortality studies through a collection of articles originally presented at two commemorative sessions at the 2021 meeting

This study presents 62 years of hindcast wave climate data for the south coast of Sweden from 1959–2021. The 100-km-long coast consists mainly of sandy beaches and eroding bluffs interrupted by headlands and harbours alongshore, making it sensitive to variations in incoming wave direction. A SWAN wave model of the Baltic Sea, extending from the North Sea to the Åland Sea, was calibrated and valida