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Clinical, Genetic and Metabolic Characterisation of LADA (Latent Autoimmune Diabetes in Adults)

Popular Abstract in Swedish KLINISK, GENETISK OCH METABOLISK KARAKTERISERING AV LADA (LATENT AUTOIMMUNE DIABETES IN ADULTS) Diabetes mellitus, sockersjuka, har blivit en allt vanligare sjukdom över hela världen. Det finns totalt drygt 100 miljoner diabetiker idag och antalet förväntas åtminstone fördubblas till år 2010. Viktiga skäl till denna nästan epidemiska utveckling är livsstilsförändringar Latent autoimmune diabetes in adults (LADA) comprises about 10% of patients initially diagnosed with type 2 diabetes but who are positive for pancreatic islet antibodies, especially to glutamic acid decarboxylase (GADabs). The present studies focused on clinical, genetic and metabolic characterisation of patients with LADA. In LADA, the frequency of the type 1 diabetes susceptibility genotype HLA-

Beyond the Usual Suspects: Critically Informed Research.

A number of researchers have attempted to define and encapsulate the essence of ‘critical research’. It has been suggested to encompass interpretation of social phenomena, and seeks for understandings that could support efforts to bring about beneficial change. It has been further suggested that such work is characterised by: concern with substantive social issues (e.g. power, values); foundation

Verification of Dose Calculation Algorithms in Treatment Planning Systems for External Radiation Therapy: A Monte Carlo Approach

Popular Abstract in Swedish För många cancerpatienter är strålbehandling ett viktigt behandlingsalternativ. En framgångsrik behandling kräver att den absorberade dosen till patienten kan ges med stor noggrannhet. Detta eftersom en liten avvikelse i absorberad dos kan påverka behandlingens resultat. Strålbehandling sker idag med avancerad teknik och utrustning där osäkerheterna i varje led i behandThis thesis presents a new verification concept, the virtual accelerator, for dose calculation algorithms used in treatment planning systems (TPSs) for external beam radiotherapy. The algorithm input data required to implement a treatment unit in the TPS are generated by Monte Carlo simulations as are the beam reference data needed for the subsequent evaluation of the dose calculation algorithm. T

The impact of ownership and board governance on firm-level entrepreneurship in small technology based firms

A growing body of research suggests that a firm’s governance system can significantly impact the long-term value creative potential of an enterprise by disciplining and encouraging organizational efforts to pursue risky entrepreneurial projects. Following this stream of research, we present a study of the impact of ownership and board governance on entrepreneurship in small technology-based firms.

Molecular dissection of the Goodpasture epitope

Popular Abstract in Swedish Den viktigaste funktionen för kroppens immunförsvar är att försvara oss mot främmande ämnen, t.ex. bakterier eller virus. Detta försvar är väldigt kraftfullt och interaktioner mellan ett par molekyler kan snabbt komma att omfatta miljontals molekyler och celler. En urspårad inflammatorisk process kan mycket snabbt komma att förstöra kroppens egen vävnad och därför finnsGoodpasture disease is a prototype autoimmune disease that is characterized by a rapidly progressive glomerulonephritis, with or without lung haemorrhage, associated with autoantibodies against the glomerular basement membrane. The major antigen has previously been shown to be the non-collagenous domain of the a3 chain of type IV collagen, one of the six known a chains of type IV collagen. On aver

Infrared spectroscopy indicates altered bone turnover and remodeling activity in renal osteodystrophy

Renal osteodystrophy alters metabolic activity and remodeling rate of bone and also may lead to different bone composition. The objective of this study was to characterize the composition of bone in high‐turnover renal osteodystrophy patients by means of Fourier transform infrared spectroscopic imaging (FTIRI). Iliac crest biopsies from healthy bone (n = 11) and patients with renal osteodystrophy

Effects of RFID technology on logistics and supply chain management: Current status and directions for future research

RFID (radio frequency identification) technology is developing at a rapid pace. During the last few years, it has been widely discussed in logistics research, as well as in other scientific fields which also approach and contribute to the development of RFID technology. In both logistics and related fields there are findings regarding RFID technology which influence logistics. However, an overall

Nightvision Based on a Biological Model

The colors and contrasts of the nocturnal world are just as rich as those found in the diurnal world. This chapter describes a recent biomimetic advance inspired by the visual systems of nocturnal insects. Since the underlying principles of both animal and camera vision are similar, it is natural to try to mimic the neural processes of nocturnal animals in order to construct efficient computer vis