Sökresultat

Filtyp

Din sökning på "*" gav 531027 sökträffar

Uncertainty quantification, propagation and characterization by Bayesian analysis combined with global sensitivity analysis applied to dynamical intracellular pathway models

Motivation: Dynamical models describing intracellular phenomena are increasing in size and complexity as more information is obtained from experiments. These models are often over-parameterized with respect to the quantitative data used for parameter estimation, resulting in uncertainty in the individual parameter estimates as well as in the predictions made from the model. Here we combine Bayesia

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Transient oligomeric species formed during the aggregation process of the 42-residue form of the amyloid-β peptide (Aβ42) are key pathogenic agents in Alzheimer’s disease (AD). To investigate the relationship between Aβ42 aggregation and its cytotoxicity and the influence of a potential drug on both phenomena, we have studied the effects of trodusquemine. This aminosterol enhances the rate of aggr

Proteogenomic characterization of patient-derived xenografts highlights the role of REST in neuroendocrine differentiation of castration-resistant prostate cancer

Purpose: An increasing number of castration-resistant prostate cancer (CRPC) tumors exhibit neuroendocrine (NE) features. NE prostate cancer (NEPC) has poor prognosis, and its development is poorly understood. Experimental Design: We applied mass spectrometry–based proteomics to a unique set of 17 prostate cancer patient–derived xenografts (PDX) to characterize the effects of castration in vivo, a

The language of the press in Soviet time and post-Soviet Russia: Creation of the citizen role through newspaper discourse

The Russian media system was during most of the 20th century part of the state institutions. During glasnost and perestroika, the media became gradually more independent of the state. However, the subsequent apex of journalistic freedom in the late 1980s and the early 1990s was followed by stagnation and a pronounced democratic setback following Putin’s accession to power. Despite this, the findin

Osteoporosis knowledge and awareness among university students in Saudi Arabia

Awareness and knowledge about any disease is the first step to prevent and treat it, so this study evaluates osteoporosis awareness and knowledge in university students. Our results showed a high awareness and good knowledge of osteoporosis. Females were better informed than males. Knowledge increased with increasing education level. PURPOSE: Osteoporosis is a worldwide health problem, including S

Living history: Russia's press and online media images of Poland in the 2000s. Implications for Russia's identity as a foreign policy actor

After the disintegration of the Soviet Union, the national identities of the Eastern and Central European states are finding themselves in a process of transformation and the results are having an impact on international relations in the region. National and foreign political identities of states are constituted by means of everyday discursive practices, not least in the media. In the present stud

Gate defined quantum dot realized in a single crystalline InSb nanosheet

A single crystalline InSb nanosheet is an emerging planar semiconductor material with potential applications in electronics, infrared optoelectronics, spintronics, and topological quantum computing. Here, we report on the realization of a quantum dot device from a single crystalline InSb nanosheet grown by molecular-beam epitaxy. The device is fabricated from the nanosheet on a Si/SiO2 substrate,

Daglig fysisk aktivitet på schemat : bättre skolresultat hos pojkarna - Men för flickorna var det ingen skillnad – Bunkefloprojektet följde grundskoleelever under nio år

One aim of the Bunkeflo project is to evaluate if daily school physical activity (PA) is associated with higher final school grades and improved eligibility for upper secondary school. One elementary school extended PA throughout elementary school to 200 minutes/week while control schools continued with in mean 60 minutes/week. We then registered final school grades and eligibility for upper secon

Structural imaging findings on non-enhanced computed tomography are severely underreported in the primary care diagnostic work-up of subjective cognitive decline

Purpose: The purpose of this study was to investigate how structural imaging findings of medial temporal lobe atrophy (MTA), posterior cortical atrophy (PCA), global cortical atrophy (GCA), white matter changes (WMC), and Evans’ index/width of lateral ventricles (EI/WLV) are reported in the primary care diagnostic work-up of patients with subjective cognitive decline or mild cognitive impairment.

No title

Ger en översikt av de kristnas situation i Mellanöstern

Search for lepton-flavor-violating decays of the Z boson into a τ lepton and a light lepton with the ATLAS detector

Direct searches for lepton flavor violation in decays of the Z boson with the ATLAS detector at the LHC are presented. Decays of the Z boson into an electron or muon and a hadronically decaying τ lepton are considered. The searches are based on a data sample of proton-proton collisions collected by the ATLAS detector in 2015 and 2016, corresponding to an integrated luminosity of 36.1 fb-1 at a cen

Polygenic Risk Score for Coronary Heart Disease Modifies the Elevated Risk by Cigarette Smoking for Disease Incidence

BACKGROUND: Coronary heart disease (CHD) is a multifactorial disease with both genetic and environmental components. Smoking is the most important modifiable risk factor for CHD. Our aim was to test whether the increased CHD incidence by smoking is modified by genetic predisposition to CHD. METHODS AND RESULTS: Our study included 24 443 individuals from the MDCS (Malmö Diet and Cancer Study). A we