Escape from cytotoxic T lymphocyte (CTL) responses toward HIV-1 Gag and Nef has been associated with reduced control of HIV-1 replication in adults. However, less is known about CTL-driven immune selection in infants as longitudinal studies of infants are limited. Here, 1,210 gag and 1,264 nef sequences longitudinally collected within 15 months after birth from 14 HIV-1 perinatally infected infant

This paper proposes a simple framework to model contextual influences on procedural decision making. In terms of utility, we differentiate between monetary payoffs and contextual psychological ones, e.g. deriving from the subjects’ normative frame of reference. Monetary payoffs are treated as common knowledge while psychological payoffs are treated as partly unforeseeable. Regarding behaviour, we

Chemical reactivity of the superheavy elements nihonium (Nh, element 113) and moscovium (Mc, element 115) has been studied by the gas-solid chromatography method using a new combined chromatography and detection setup. The Mc isotope, 288Mc, was produced in the nuclear fusion reaction of 48Ca ions with 243Am targets at the GSI Helmholtzzentrum Darmstadt, Germany. After isolating 288Mc ions in the

We compute top quark pair production in association with a bottom quark pair at the LHC within the five-flavour scheme, matched to a parton shower, employing the FxFx merging scheme for tt¯+jets production with up to 2 jets at NLO accuracy. To enhance the selection efficiency for the events with b-jets within the inclusive five-flavour sample, we augment the generation probability of bottom quark

A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,0

This paper provides analytical solutions to the closed-loop kinematics of two almost globally exponentially stabilizing attitude control laws on the special orthogonal group SO(n). By studying the general case we give a uniform treatment to the cases of SO(2) and SO(3), which are the most interesting dimensions for application purposes. Working directly with rotation matrices in the case of SO(3)

Manipulating the light polarization properties of gold nanoparticle aggregates can facilitate their applications in sensing and imaging. However, control of the intrinsic light polarization on demand at the nanoscale is hindered by the lack of a fundamental understanding of the structure-dependent plasmon coupling in the aggregates. Here, the polarization properties of intrinsic photoluminescence

In the period between 5,300 and 4,900 calibrated years before present (cal. bp), populations across large parts of Europe underwent a period of demographic decline1,2. However, the cause of this so-called Neolithic decline is still debated. Some argue for an agricultural crisis resulting in the decline3, others for the spread of an early form of plague4. Here we use population-scale ancient genomi

In this paper, we solve an inverse resonance problem for the half-solid with vanishing stresses on the surface: Lamb's problem. Using a semiclassical approach, we are able to simplify this three-dimensional problem of the elastic wave equation for the half-solid as a Schr\"odinger equation with Robin boundary conditions on the half-line. We obtain asymptotic values on the number and the location o

IMPORTANCE Numerous prospective cohort studies have reported a J-shaped association of urinary sodium excretion with cardiovascular events and mortality. OBJECTIVE To study the association between sodium intake and incident atrial fibrillation (AF). DESIGN, SETTING, AND PARTICIPANTS This cohort study included participants in the Ongoing Telmisartan Alone and in Combination with Ramipril Global End

Objective To compare experiences of the second stage of labour in women randomised to assistance by one or by two midwives to reduce severe perineal trauma (SPT). Design Analysis of a secondary outcome within the Swedish Oneplus multicentre randomised trial. Setting Five obstetric units in Sweden between December 2018 and March 2020. Participants Inclusion criteria in the Oneplus trial were women

Background: Many individuals with hypertension remain undiagnosed. We aimed to develop a predictive model for hypertension using diagnostic codes from prevailing electronic medical records in Swedish primary care. Methods: This sex- and age-matched case-control (1:5) study included patients aged 30–65 years living in the Stockholm Region, Sweden, with a newly recorded diagnosis of hypertension dur

The aim of this study was to identify a Bifidobacterium strain that improves the performance of Limosilactobacillus reuteri DSM 17938. Initial tests showed that Bifidobacterium longum subsp. longum strains boosted the growth of DSM 17938 during in vivo-like conditions. Further characterization revealed that one of the strains, BG-L47, had better bile and acid tolerance compared to BG-L48, as well

Many animals avoid detection or recognition using camouflage tailored to the visual features of their environment.123 The appearance of those features, however, can be affected by fluctuations in local lighting conditions, making them appear different over time.45 Despite dynamic lighting being common in many terrestrial and aquatic environments, it is unknown whether dynamic lighting influences t

ChatGPT has gained increased attention as an artificial intelligence (AI)-based tool in the field of tourism and hospitality education in recent years. This study investigates the impact of perceived ease of use, perceived usefulness and authenticity on student attitude and intention to use ChatGPT by incorporating the concept of authenticity into the technology acceptance model (TAM) theoretical

Background and purpose: The Swedish Lymphoma Register (SLR) was initiated in the year 2000 with the aim to monitor quality of care in diagnostics, treatment and outcome of all lymphomas diagnosed nationally among adults. Here, we present the first systematic validation of SLR records as a basis for improved register quality and patient care. Patients and methods: We evaluated timeliness and comple

Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas

Endomucin (EMCN) currently represents the only hematopoietic stem cell (HSC) marker expressed by both murine and human HSCs. Here, we report that EMCN+ long-term repopulating HSCs (LT-HSCs; CD150+CD48−LSK) have a higher long-term multi-lineage repopulating capacity compared to EMCN− LT-HSCs. Cell cycle analyses and transcriptional profiling demonstrated that EMCN+ LT-HSCs were more quiescent compa