Obesity and type 2 diabetes are increasing at alarming rates worldwide, presenting significant public health challenges. A key player in these conditions is GLUT4, a protein that helps transports glucose into cells in response to insulin. Proper function of GLUT4 is crucial for maintaining healthy blood sugar levels and overall metabolic health.To address this, in this thesis I have explored the m

När det internationella samfundet under ”superutvecklingsåret” 2015 åtog sig uppgiften att utrota fattigdom och hunger var det under löftet ”Leave no one behind”, dvs att alla överallt ska inkluderas och få ta del av utvecklingens framsteg. Hur kan ett sådant löfte bli verklighet och vilka utmaningar ligger framför oss? Denna översiktsartikel syftar till att ta itu med dessa frågor genom att fokus

Young people have been prominent climate advocates globally and they are also becoming increasingly visible in global climate politics. They have participated in Conferences of the Parties (COPs) to the United Nations Framework Convention on Climate Change (UNFCCC) since COP1 in 1995. While recent studies have started to examine the representativeness and participation of youth at the COPs, we sti

This research presents advancements into the fabrication, operation and characterization of electronicnanomaterials and devices. It focuses on the interfaces of metals, oxides and semiconductors anddeveloping techniques to improve their integration into devices. Covering nanoelectronics fromphotovoltaics to circuit elements, a combined suite of scanning probe and X-ray techniques was usedto provid

Kraft black liquor (KBL) is a side-stream that is produced during the kraft pulping process, and mainly contains lignin, hemicelluloses, and cooking chemicals, namely sodium hydroxide and sodium sulphide. KBL is usually evaporated and burned in a recovery boiler in order to recover the cooking chemicals and generate energy. However, pulp mills are sometimes limited by the capacity of their recover

Youth represent a great part of humanity and have always been active and intriguing political actors, yet youth remain sidelined in international studies. Issues of social identity perception and its consequences have been embraced by post-positivist approaches in international studies. Yet, while race, gender, and class challenges are shaking the discipline, age is a key research gap. To fill thi

A popular uprising in 2014, led to a revolution that overthrew the sitting President of Burkina Faso. We investigate if individuals' risk attitudes changed due to this revolution. We examine this impact by the main determinants of risk attitudes: gender, age and level of education. The analysis is based on unique panel survey data, allowing us to track the changes in the risk attitudes of the sameA popular uprising in 2014, led to a revolution that overthrew the sitting President of Burkina Faso. We investigate if individuals' risk attitudes changed due to this revolution. We examine this impact by the main determinants of risk attitudes: gender, age and level of education. The analysis is based on unique panel survey data, allowing us to track the changes in the risk attitudes of the same

Causal networks are essential in many applications to illustrate causal relations in dynamical systems. In a view of statistics, Granger Causality (GC) gives a definition for causal ordering of time series, which implies a parametric model for stationary processes. In a systematic view, Dynamical Structure Function (DSF) is proposed to provide a general parametric representation for linear causal

Objectives To compare the treatment effectiveness of secukinumab in radiographic (r) versus non-radiographic (nr) axial spondyloarthritis (axSpA) patients treated in routine care across Europe. Methods Prospectively collected data on secukinumab-treated axSpA patients with known radiographic status were pooled from nine countries. Remission rates based on patient-reported outcomes (PROs; Numeric R

Non-technical summaryBrazil – one of the world's largest biocultural diversities – faces high rates of habitat loss, social inequality, and land conflicts impacting indigenous and local peoples. To challenge that, Brazilian sustainability science and education needs to be strengthened. We searched for elements in ongoing bottom-up sustainability social movements that can help serve that purpose. W

Proteins are adjustable units from which biomaterials with designed properties can be developed. However, non-native folded states with controlled topologies are hardly accessible in aqueous environments, limiting their prospects as building blocks. Here, we demonstrate the ability of a series of anhydrous deep eutectic solvents (DESs) to precisely control the conformational landscape of proteins.

One step towards understanding bone fragility and degenerative diseases is to unravel the links between fracture resistance and the compositional and structural characteristics of cortical bone. In this study, we explore an optical method for automatic crack detection to generate full fracture resistance curves of cortical bone. We quantify fracture toughness, critical failure strains at the crack

Aims To explore whether circulating matrix metalloproteinase-2 (MMP-2), MMP-9, MMP-9/neutrophil gelatinase-associated lipocalin, MMP-9/tissue inhibitor of metalloproteinase-1 (TIMP-1), MMP-14, TIMP-2 and TIMP-3 were associated with the severity and progression of diabetic retinopathy (DR) in patients with type 1 diabetes (T1D). Methods Baseline and prospective analyses were conducted over a period

The "Likhall"bed is a rare case of a single-age zircon population from a carbonate rock, which in this case is contextualised with remarkable biotic and environmental changes and with meteorite bombardment of Earth after an asteroid breakup in space. Published high-precision chemical abrasion isotope dilution thermal ionisation mass spectrometry (CA-ID-TIMS) U-Pb age estimates disagree on the typi

Objectives: Bacteremia is an acute severe infection with high mortality. Changes in healthcare services and coinfections with SARS-CoV-2 may have affected the mortality for bacteremia during the COVID-19 pandemic, which has been reported for other major diseases. In this study we examine the all-cause bacteremia mortality amidst the COVID-19 pandemic. Methods: A population-based cohort study compr

The quark spin effects are introduced for the first time in the string fragmentation routine of the Pythia 8 Monte Carlo event generator for the simulation of e+e− annihilation to hadrons. To describe the spin effects the string+3P0 model of polarized hadronization with emissions of pseudoscalar and vector mesons is used. The spin effects are activated in the generator by extending the StringSpinn

Genome-wide association studies (GWAS) for biomarkers important for clinical phenotypes can lead to clinically relevant discoveries. Conventional GWAS for quantitative traits are based on simplified regression models modeling the conditional mean of a phenotype as a linear function of genotype. We draw attention here to an alternative, lesser known approach, namely quantile regression that natural

Phosphoglucomutase-1-congenital disorder of glycosylation (PGM1-CDG) is a rare genetic disorder caused by biallelic variants in the PGM1 gene, leading to the deficiency of the PGM1 enzyme. The most common clinical presentations include muscle involvement, failure to thrive, cleft palate, and cardiac involvement. Abnormal serum N-glycosylation, hypoglycemia, and liver function abnormalities includi

Obesity and Type 2 diabetes (T2D) are known to exacerbate cerebral injury caused by stroke. Metabolomics can provide signatures of metabolic disease, and now we explored whether the analysis of plasma metabolites carries biomarkers of how obesity and T2D impact post-stroke recovery. Male mice were fed a high-fat diet (HFD) for 10 months leading to development of obesity with T2D or a standard diet