Two-dimensional neuronal cultures have a limited ability to recapitulate the in vivo environment of the brain. Here, we introduce a three-dimensional in vitro model for human glia-to-neuron conversion, surpassing the spatial and temporal constrains of two-dimensional cultures. Focused on direct conversion to induced dopamine neurons (iDANs) relevant to Parkinson disease, the model generates functi

UNLABELLED: Serine protease inhibitors (serpins) constitute the largest family of protease inhibitors expressed in humans, but their role in infection remains largely unexplored. In infected macrophages, the mycobacterial ESX-1 type VII secretion system permeabilizes internal host membranes and causes leakage into the cytosol of host DNA, which induces type I interferon (IFN) production via the cy

Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterized by the aggregation of β-amyloid (Aβ) and tau in the brain. Breakthroughs in disease-modifying treatments targeting Aβ bring new hope for the management of AD. But to effectively modify and someday even prevent AD, a better understanding is needed of the biological mechanisms that underlie and link Aβ and tau

Before electronic products reach the market, Functional Circuit Testing (FCT) is an essential process to ensure performance and reliability. Traditional FCT requires developing dedicated testing firmware for each batch of products, which increases both development costs and time. This thesis proposes a testing method based on Boundary Scan, provides an alternative that eliminates the need for firm

Purpose: The purpose of this paper is to analyze the effect woke marketing has on the consumer and the effect it has on the brand’s identity Methodology: The research paper uses a qualitative approach, including both primary and secondary data collection. The primary data was collected through six semi-structured interviews examining brand identity, woke culture and brand versus market orientation

Purpose: This paper aims to investigate how Monki’s decision to reduce its size range, a strategic choice that contradicts its inclusive brand identity, affects its brand image and how these actions can be justified. Design/method: This paper is based on two qualitative research methods. To gather primary data, semi-structured interviews were conducted to investigate the perceptions of young Swed

Denna text analyserar musikens roll i skapandet av dokumentärer och undersöker hur kompositören kan påverka det slutliga verket och vilken roll musiken har i det. Den belyser vikten av tidigt samarbete mellan tonsättare och regissör med betoning på öppen kommunikation och ömsesidig respekt. För detta genomfördes intervjuer där samma scen presenterades med två olika musikstycken. Sedan analyseradesTitle in English: The hidden embodiment of the story - An approach to music in documentary film. This text analyzes the role of music in the creation of documentaries and examines how the composer can influence the final work and what role music plays in it. It highlights the importance of early collaboration between composer and director with an emphasis on open communication and mutual respect.

ObjectiveIndividuals with neurodevelopmental and/or neurocognitive disorders (NNDs) have complex, long-term care needs. In Bangladesh, India, and Pakistan, informal carers shoulder the responsibility and strain of providing care for people with NNDs. Intense care demand, societal and cultural care expectations, and lack of support infrastructure often lead to psychosocial strain in this inadequate

EU law has developed with close ties to economic growth, and relatedly, various scholars have historically expressed critiques which would today be considered part of the Law and Political Economy approach. What is starkly absent from the relevant critiques is the way in which EU law regulates the migration phenomenon and its relation to the market. Migration law scholarship has been focusing on t

The initial interview is a critical moment in the relationship between the patient and the palliative care team. Good communication skills, while always important in clinical medicine, are especially indispensable in this context, where a life-threatening illness and associated fear, anxiety, sadness, and hope can make for a challenging clinician-patient relationship. When done expertly, the initi

Hur möter vi vintern? Hur kan vi bidra till en bättre psykisk hälsa under vinterhalvåret med arkitekturens redskap till hjälp? Vintern kan vara en grå tid speciellt i Lund, en tid som tynger ned våra sinnen. I mitt arbete vill jag undersöka hur arkitektur och arkitekturens verktyg, kan bidra till ökad hälsa och bättre mående. Genom kunskapsinsamling om hur utomhusmiljöer påverkar oss och an

Germany‘s small towns are facing major challenges and at the same time offer great potential for relieving pressure on German cities. 24 million people currently live in the approximately 2,100 small towns, which is around 29% of the total population. The research shows that, on the one hand, small towns are struggling with demographic change and out-migration, especially of young people. On the

The entanglement of domestic and geopolitical dynamics with the evolution of the aid strategies of the Gulf States is particularly evident in the Horn of Africa (HOA), where the regional competition for exercising influence has affected the modalities of humanitarian and development interventions. A comparison of the foreign aid given by Qatar and the United Arab Emirates (UAE) to Sudan in the con

Denna avhandling undersöker 1998 års svenska förbud mot sexköp utifrån den uppmärksamhet lagen fått som ett unikt tillvägagångssätt för att reglera prostitution, den starkt polariserade politiska miljö den existerar inom och de många juridiska motsägelser den uppvisar. Genom material insamlat genom en multisituerad metod mellan åren 2009 och 2019 visar studien att sexköpsförbudet är en variant av This essay thesis examines Sweden’s 1999 ban on purchasing sexual services, considering the attention it received as an unprecedented approach to governing prostitution, the highly polarised political environment in which it exists, and the multiple legal contradictions it displays. Using material gathered through a multisited method from 2009 through 2019, the study shows that the offence is a va

Though augmented reality (AR) is increasingly adopted in marketing, its capacity to foster consumers' engagement and attachment remain tenuous, exposing an important literature-based gap. Addressing this gap, we deploy social presence theory and luxury consumption theory to develop and test a model that proposes that consumers' engagement with AR-deploying luxury brands drives the development of t

”It should be of use for the military enlightenment” : a study in History of Knowledge of The Royal Swedish Academy of War Sciences publication Handlingar 1797–1825 This thesis presents an analysis of The Royal Swedish Academy of War Sciences publication Handlingar between 1797–1825 from the perspective of history of knowledge. The purpose of this study is twofold. Partly to provide a greater un

Study region: The NekooAbad Irrigation District in central Iran faces challenges due to inefficient surface water distribution. 82 million m3 of groundwater is extracted annually from 15,000 tube-wells, leading to decreased groundwater levels and increased energy consumption of 234 million kWh per year. Study focus: This study explores implementing automation in surface water distribution to reduc