INTRODUCTION: We aimed to assess the impact of cholinesterase inhibitors (ChEIs) and memantine on cognition, major adverse cardiovascular events (MACE) and mortality in dementia with Lewy bodies (DLB). METHODS: A total of 1,095 incident DLB patients from the Swedish Registry on cognitive/dementia disorders were included. Using an inverse probability of treatment weighting, the effect of initiating

STUDY QUESTION: Can human pre- and peri-pubertal testicular cells obtained from childhood cancer patients, previously treated with chemotherapy, form testicular organoids (TOs)? SUMMARY ANSWER: Organoid formation from testicular tissue collected from childhood cancer patients positively correlates with SRY-Box transcription factor 9 (SOX9) expression in Sertoli cells, which in turn negatively corr

Introduction: Infective endocarditis (IE) is a challenging diagnosis to suspect and to confirm. The purpose of this study was to clarify how often IE is suspected already on hospital admission, which clinical signs trigger the physicians’ suspicions and to investigate if the empirical treatment is adequate. Methods: A retrospective observational study of cases with definitive IE, during 2018–2019

Functional amyloids formed by the protein FapC in Pseudomonas bacteria are key structural components of Pseudomonas biofilms, which mediate chronic infections and also contribute to antimicrobial resistance. Here, we combine kinetic experiments with mechanistic modelling to probe the role of surfaces in FapC functional amyloid formation. We find that nucleation of new fibrils is predominantly hete

Background and objective: This publication represents a summary of the updated 2024 European Association of Urology (EAU) guidelines for non–muscle-invasive bladder cancer (NMIBC), TaT1, and carcinoma in situ. The information presented herein is limited to urothelial carcinoma, unless specified otherwise. The aim is to provide practical recommendations on the clinical management of NMIBC with a fo

Panel for Pollen Conference in Lund 2024Exploring transitions for marine environmental governance: the potential of communities and bottom-up processes as alternative pathways to sustainabilityFacilitating the potential of communities and bottom-up governance for transitions to sustainability (T2S) sparks key questions of political ecology. Marine environmental governance exposes such challenges r

The future of AIS conferences, thrown into sharp relief by virtual innovations during the pandemic and the subsequent return to face-to-face conferences, is debated in this special issue. This editorial introduces the seven papers contained in the special issue and provides the context for the debate on the future of conferences in the AIS Community as well as pinpointing key contributions made by

Background:Several previous studies have analyzed patient experiences of long-acting injectable buprenorphine (LAIB) in treating opioid use disorder (OUD). This treatment approach reduces the need for daily supervised clinic visits, but also fundamentally changes the dynamic of the relationship between patients and staff. The perspective of staff working with opioid agonist treatment (OAT) on LAIB

How to include knowledge and actors from local and regional levels like small-scale fishers and their communities in overarching governance frameworks? This is a pertinent question for ongoing Blue Economy processes, as highlighted e.g., in the Manifesto from the 2021 MARE conference. In an ongoing “from research to practice” project, we investigate how to include local and regional perspectives a

Introduction: Postnatal perineal pain is prevalent following childbirth and can impact women both physically and emotionally. The aim of the study was to study the effect of collegial midwifery assistance on perineal pain and pain medication 1 month after birth and to investigate the associations between the type of tear and perineal pain, satisfaction with healing, and resumption of intercourse.

Staphylococcus argenteus was recently defined as a species and has previously often been mistaken for Staphylococcus aureus due to the difficulties of conventional laboratory methods to distinguish the two species. The clinical presentation of infections caused by S. argenteus is largely unknown, and its virulence has since the definition of the species been debated. Here we present, to our knowle

As society's capacity for data collection increases, the need for automated processing techniques becomes increasingly relevant. One way to evaluate data is to find the subset which does not conform to normal behaviour, i.e., anomalies. If the data is in the form of trajectories in some space, the algorithms used to find these are trajectory anomaly detection algorithms. In this paper, the tra

Quadratic time-frequency representations are indispensable tools in non-stationary signal analysis. Thus the incorporation of such tools into signal detection is pre- dicted to yield more sensitive detectors especially in the context of non-stationary signal detection. We elucidate the theory of time-frequency representations and signal detection then implement a time-frequency detector using Wign

Inquiries into properties of brain structure and function have progressed due to developments in magnetic resonance imaging (MRI). To sustain progress in investigating and quantifying neuroanatomical details in vivo, the reliability and validity of brain measurements are paramount. Quality control (QC) is a set of procedures for mitigating errors and ensuring the validity and reliability of brain

Aim: Aquatic-terrestrial transition zones contain features essential for many species that often benefit wetland biodiversity. Shallow flood-zone areas and reed beds are indicative of natural wetland habitats; however, how such features affect the native arthropod biodiversity in constructed wetlands is scarcely investigated. We asked how these shoreline features, as well as wetland shoreline prop

Natural climate oscillations can cause extreme events such as floods and droughts. The mid-1970s is known for the occurrence of a global Climate Shift, defined as a short period when both interannual and interdecadal climate oscillations changed phases, which led the climate to a new state. Climate Shift has affected many regions and is considered an unprecedented event. In this chapter, we descri