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Performance of PCR-based syndromic testing compared to bacterial culture in patients with suspected pneumonia applying microscopy for quality assessment

Syndromic testing for lower respiratory tract infections with BioFire® FilmArray® Pneumonia Panel Plus (BF) detects 27 pathogens with a turn-around-time of one hour. We compared the performance of BF with culture. Samples from 298 hospitalized patients with suspected pneumonia routinely sent for culture were also analyzed using BF. Retrospectively, patients were clinically categorized as having "p

Change in economic burden of diarrhoea in children under-five in Bangladesh : 2007 vs. 2018

BACKGROUND: In Bangladesh, diarrhoea in children under-five is a major public health problem with cost implications. Although under-five diarrhoea mortality and morbidity have declined from 2007 to 2018, change in the economic burden is unknown. This study determined the change in the societal economic burden of under-five diarrhoea in Bangladesh comparing 2007 to 2018.METHODS: A prevalence-based,

In vivo dendritic cell reprogramming for cancer immunotherapy

Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor microenvironment. Here, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, IRF8, and BATF3, which enabled them to present antigens as t

Airborne SARS-CoV-2 RNA detected during deliveries with unmasked patients

Background: Healthcare workers in obstetric clinics may be exposed to airborne SARS-CoV-2 when treating patients with COVID-19.Method: In this study, performed during the midst of the pandemic, air samples werecollected in delivery rooms during childbirth and analysed for SARS-CoV-2 RNA content.Result: Six of 28 samples collected inside delivery rooms were positive for SARS-CoV-2, but none in ante

Assessment of Childhood Stunting Prevalence over Time and Risk Factors of Stunting in the Healthy Village Programme Areas in Bangladesh

Childhood stunting is a significant public health concern in Bangladesh. This study analysed the data from the Healthy Village programme, which aims to address childhood stunting in southern coastal Bangladesh. The aim was to assess childhood stunting prevalence over time and explore the risk factors in the programme areas. A cross-sectional, secondary data analysis was conducted for point-prevale

Treatment With Reduced-Dose Trimethoprim-Sulfamethoxazole Is Effective in Mild to Moderate Pneumocystis jirovecii Pneumonia in Patients With Hematologic Malignancies

BACKGROUND: Recent studies have reported that reduced-dose trimethoprim-sulfamethoxazole (TMP-SMX) may be effective in the treatment of Pneumocystis jirovecii pneumonia (PJP), but data are lacking for patients with hematologic malignancies.METHODS: This retrospective study included all adult hematologic patients with PJP between 2013 and 2017 at 6 Swedish university hospitals. Treatment with 7.5-1

Anoikis-related genes linked with patient outcome in pancreatic cancer

Anoikis is programmed cell death occurring upon cell detachment from the extracellular matrix. Cancer cells need to evade anoikis to be able to metastasize to distant sites. However, the molecular features and prognostic value of anoikis-related genes (ARGs) in pancreatic cancer remain unclear. In this study, we utilized transcriptome data from the TCGA and GSE102238 databases to identify 64 ARGs

Statelessness and Displacement: The Cause, Consequences, and Challenges of Statelessness and Capabilities Required of Social Workers

This chapter explores the impact of being statelessness on individuals and communities who are displaced. It starts with an overview of statelessness, the numbers those people affected, the major stateless populations around the world, how statelessness is created and perpetuated and the presentation of two case studies of displaced stateless populations. Following this, it covers the challenges t

Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020 -May 2021

INTRODUCTION: Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk of hospitalisation and admission to an intensive care unit (ICU) for infections with B.1.1.7 and B.1.351 in Norway, compared to infections with non-VOC.MATERIALS AND METHODS: Using linked individual-level data from national registries, we conducted a cohort stu

Using the Futures Cone in Doctoral Supervision

I denna artikel reflekterar jag över användandet av futures cone och expanded futures cone (hämtade ur queer-teori) som verktyg för dialog och planering mellan handledare och doktorand. Detta görs genom att relatera verktyget till tre typer av handledning: ett produktorienterat, ett processorienterat och ett doktorandorienterat förhållningssätt. Jag hävdar att det är ett underanvänt och mångsidigtThis article is a reflection piece on the use of the futures cone and an expanded futures cone (which draws on queer theory) as a tool for dialogue and planning between the supervisor and the doctoral student. I do so by situating the use of this tool in relation to three supervision typologies: the product-orientated,process-orientatedand doctoral student-orientated approaches. I claim that it is

Length of hospital stay and risk of intensive care admission and in-hospital death among COVID-19 patients in Norway : a register-based cohort study comparing patients fully vaccinated with an mRNA vaccine to unvaccinated patients

OBJECTIVES: We estimated the length of stay (LoS) in hospital and the intensive care unit (ICU) and risk of admission to ICU and in-hospital death among COVID-19 patients ≥18 years in Norway who had been fully vaccinated with an mRNA vaccine (at least two doses or one dose and previous SARS-CoV-2 infection), compared to unvaccinated patients.METHODS: Using national registry data, we analyzed SARS-

Science and Innovation : A Cyclical Approach

To formally understand cyclicity in innovation and to tie to Schumpeter’s idea about waves of creative destruction, we elaborate upon Thomas Kuhn’s (1962) hypothesis that science evolves through a succession of paradigm life cycles by noting that entrepreneurs recognize the profitability of new scientific theories through a delay. The delay from innovation to entrepreneurship may be due to technol

Disruptive Possibilities: AI and Planetary Health

This short playful piece is a result of my participation in the Collaborative Foresight Cycle on the Futures of AI and Sustainability. Hosted by Media Evolution in Malmö between May and June 2022, the Cycle brought together a broad range of actors to co-create and explore the future possibilities of AI in relation to sustainability. This piece is a response to the hopelessness which has arisen due

The Participation Paradox in the Politics of AI

AI systems are increasingly being used to shift decisions made by humans over to automated systems, potentially limiting the space for democratic participation. The risk that AI erodes democracy is exacerbated where most people are excluded from the ownership and production of AI technologies that will impact them.AI learns through datasets but, very often, that data excludes key parts of the popu

'I Must Be from Somewhere. I'm Not from the Moon': Navigating the Politics of Labelling for Stateless Palestinian Refugees from Syria

This article explores the relationship between statelessness and refugeeness over time and space. It does so by drawing on how Palestinian refugees from Syria in Sweden navigate the various stateless and refugee labels imposed upon them before, during and after their flight from Syria to Sweden. Standpoint theory was deployed as the basis for understanding how this group of stateless refugees rela

Qualitative Field Study of Host Community/Refugee from Syria Relations in Croatia, Germany, Jordan and Sweden : FOCUS Research Project Deliverable 4.2

The FOCUS project is undertaking a range of research and piloting tasks which aim to improve understanding of dynamic integration and to assist the implementation of effective practices. As part of this work a detailed programme of qualitative research has been undertaken in four countries. This report presents the country-specific findings of this research, which will be further consolidated in a

Creative Work and Public Policy

In post-industrial society, creativity has become a universal remedy for a range of societal challenges. Policymakers increasingly design policies where the notion of creativity is central. This chapter takes a closer look at how policymakers seek to facilitate creative work, and why policy related to creative work assumes the form it does. The chapter draws empirically from a longitudinal study o