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We investigate the computation of stable fracture paths in brittle thin films using one-dimensional damage models with an elastic foundation. The underlying variational formulation is non-convex, making the evolution path sensitive to algorithmic choices. In this paper, we inquire into the effectiveness of quasi-Newton algorithms as an alternative to conventional Newton-Raphson solvers. These algo
Att placeras på HVB är en av de mest ingripande insatserna inom socialt arbete. För ungdomar innebär den ofta att tillvaron blir präglad av förändring och en känsla av att framtiden är osäker. Licentiatuppsatsen fördjupar kunskapen kring existentiella utmaningar som kan uppstå i denna process. Studien har en teoretisk utgångspunkt i existentiell filosofi och fokuserar på hur grundläggande livsvillWhen young people are placed in residential care (HVB) it is one of the mostfar-reaching interventions in social work, often involving significantdisruptions to their everyday lives, future outlook, and sense of self. Whilesuch placements frequently raise questions about meaning and freedom thesechallenges remain largely unexplored from an existential perspective in bothresearch and practice. This
Every day, new decisions are made, ranging from trivial to critical, and their impact can vary greatly. Despite these differences, all decisions share a common goal: to choose the best possible action based on the knowledge available at the time. In some cases, past events offer little insight into what lies ahead. However, in many situations, especially in structured environments, historical patt
Industrial redevelopment has become an increasingly pressing urban challenge as cities expand and central industrial areas are drawn into the evolving urban fabric. While regeneration projects often succeed in giving former industrial sites new roles, the preservation of the industrial legacy is frequently reduced due to the conflicting demands between industrial and central urban functions. What
The eighteenth century marks a watershed in European intellectual history. It witnessed the development of many civil rights ideas that were prerequisites for the emergence of modern political systems. One principle that appears to be supported by numerous empirical examples is that evolving political pluralism fostered the right to express one’s views with a certain degree of freedom. This articl
Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema--a transient structure that houses a pool of progenitor cells that regenerate the missing tissue. We have identified the expression of von Willebrand Factor D and EGF Domains (vwde) as a common feature of blastemas capable of
Cytostatic pharmaceuticals are not completely removed in wastewater treatment plants (WWTPs) and may affect aquatic ecosystems. Their quantification is challenging due to variations in wastewater characteristics, which influence analytical performance. An analytical procedure has been developed, based on solid-phase extraction and liquid chromatography coupled with tandem mass spectrometry, for th
The increasing use of digital tools in archaeology has vastly expanded our capacity to document and visualise the past, yet the reasoning that connects evidence to interpretation often remains implicit or undocumented. This paper addresses that gapby integrating Inference to the Best Explanation (IBE)—a philosophical model of hypothesis evaluation—into the Archaeological Interactive Report (AIR),
The royal Danish-Norwegian flagship Gribshunden, launched in 1485, was amongthe earliest northern European warships purpose-built to carry artillery. However, King Hans employed his vessel as far more than a weapons platform. The ship was his ‘floating castle’, fulfilling all the various purposes of a land redoubt. At its loss in 1495 enroute to a political summit in Kalmar, where Hans expected to
Dynamic quantum effects in biological systems is a hotly debated question, which since recently has been experiencing renewed wave of broad attention [1]. This discussion was initiated by the application of the multidimensional spectroscopy techniques for investigating dynamics in biological complexes. Is nature really optimized to use non-trivial quantum effects, like dynamically evolving coheren
I denna artikel presenteras en närstudie av uppmaningar av typen Om ni är tysta, det vill säga om-inledda af-satser med uppmanande funktion. Syftet med studien är att undersöka funktionen hos uppmaningar som uttrycks med om-inledda af-satser i en idrottspedagogisk kontext. Materialet som ligger till grund för studien består av inspelningar från 26 idrottsaktivitetstillfällen. I detta material kan
När Försvarare Blir Fördärvare Vårt immunförsvar skyddar oss från infektioner och sjukdomar, och det förändras i och med att vi åldras. En speciell typ av cell går obemärkt förbi tills vi når en hög ålder, råkar ut för infektioner, eller drabbas av autoimmuna sjukdomar. De här cellerna kallas age-associated B cells (ABC) på engelska. Vissa forskare påstår att de har en betydande roll och kan föruAge-associated B cells (ABCs) are a novel subtype of B cells that accumulate with ageing, during infection, and in the progression of autoimmune diseases. Still, their exact phenotype and effector functions remain unknown. In this thesis, we aimed to provide an immunological characterisation of human ABC subsets by phenotyping them before and after in vitro stimulation and evaluating the alteratio
Type 2 diabetes is characterized by pancreatic β-cell dysfunction and insulin resistance. There are various studies about the contributing molecular mechanisms, and our recent findings show that the complement inhibitor Cd59 might play a non-canonical role in insulin secretion. Specifically, knock-out of Cd59 greatly inhibits glucose-stimulated insulin secretion. This, however, can be rescued by t
Polyhydroxyalkanoates (PHAs) are microbial bio polyesters that offer a promising biodegradable alternative to petroleum-derived plastics. This thesis focuses on the production and characterization of medium-chain-length PHAs (mcl-PHAs) by Pseudomonas putida using octanoic acid as a carbon source. The main aim was to optimize key bioprocess parameters such as temperature, pH, dissolved oxygen (DO),
Charge generation, injection and recombination in quantum dot-sensitized ZnO nanowires was probed using time resolved terahertz spectroscopy. The mobility spectrum at different representative pump-probe delays showed similar behavior during the injection time indicating free charges on the nanowire structures.
We have studied van der Waals contacts of the carotenoid rhodopin glucoside (RG) with the bacteriochlorophyll pigments absorbing at 800 nm (B800) in the crystal structure of Rhodopseudomonas acidophila, and the hydrogen positions were determined from quantum chemical calculations at the Hartree–Fock (6-31G) level. We have found strong evidence for hydrogen bonding between the B800 BChl and the
