Acute-phase inhibition of the pro-inflammatory alarmin S100A8/A9 improves cardiac function post-myocardial infarction (MI), but the mechanisms underlying the long-term benefits of this short-term treatment remain to be elucidated. Here, we assessed the effects of S100A8/A9 blockade with the small-molecule inhibitor ABR-238901 on myocardial neovascularization in mice with induced MI. The treatment

Applying research into assessments of community theatre, epidemiology, and young people's shared and private stories using a wide range of methodologies, this book explores the potential efficacy of community theatre to prevent the spread of HIV/AIDS in Tanzania with reference to several other comparable sites in Africa.Applying research into assessments of community theatre, epidemiology, and young people's shared and private stories using a wide range of methodologies, this book explores the potential efficacy of community theatre to prevent the spread of HIV/AIDS in Tanzania with reference to several other comparable sites in Africa.

Chorea-acanthocytosis (ChAc), an autosomal recessive disorder, is associated with cognitive and behavioral abnormalities. Previous studies were focused around exploring the functional annotation of VPS13A gene in ChAc, whereas the genetic labyrinth underlying this disease and plausible drug targets were underexplored. In the present study, we have identified the pivotal genes and molecular pathway

This study explores the implementation of a complementary currency – an alternative approach to addressing the problem of poverty caused by the scarcity of conventional money. Complementary currencies can be defined as agreement within communities to use something different to a national currency as a standardized medium of exchange. Previous research has examined the various classifications and o

Gastrointestinal malignancies are one of the major worldwide health concerns. In the present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) against gastrointestinal cancer. By modulating several signaling pathways critical in cancer development, UA could offer anti-inflammatory, anti-proliferative, and anti-metastatic properties. However, being of low oral bioa

For many severe lung diseases, non-invasive biomarkers from imaging could improve early detection of lung injury or disease onset, establish a diagnosis, or help follow-up disease progression and treatment strategies. Imaging of the thorax and lung is challenging due to its size, respiration movement, transferred cardiac pulsation, vast density range and gravitation sensitivity. However, there is

The lifestyle and consumption patterns of the wealthy exceed our planet's ecological limits. Surprisingly, little experimental research explores the effectiveness of choice architecture interventions targeting the lifestyles and consumption behaviours of the affluent. Addressing this gap, our study investigates the extent to which the top income decile in Sweden can be motivated to take climate ac

Sammanfattning Som en konsekvens av den pågående debatten om vattenkraftverkens samhällsnytta och klimatpåverkan finns ett allt större krav på att riva eller miljöanpassa kraftverksdammar i Sverige. I Rönne å i Klippans kommun har tre vattenkraftverk lagt ner sin elproduktion i samband med att dammarna ska rivas nästa år. I det här examensarbete tar jag ställning till en ny potentiell framtid förAbstract As a consequence of the ongoing debate about the human benefits and detrimental climate impact of hydropower plants, there is an increasing call to either demolish the dams or environmentally adapt them across Sweden. In Rönne å, three hydropower plants have shut down their electric production as their dams are set to be demolished next year. In my thesis, I take a position on a new pote

Since the fall of 2017, when it was brought to the public debate, gender-inclusive writing has sparked passionate reactions. The debates generated by this linguistic practice are divisive and the discussion on certain aspects, such as the so called midpoint, is paralysed. Many arguments are mobilised by opponents, such as the unreadability of gender-inclusive writing, or the absence of ambiguity i

This article investigates the dependence on standard contracts in Swedish construction law, particularly AB 04 and ABT 06, due to a lack of specialized laws. Comparing them to similar contracts from other Nordic countries demonstrates the value of cross-border legal understanding. A 2018 Swedish Supreme Court judgment highlights this technique, implying that comparative analysis might improve lega

The use of N-heterocyclic carbenes in conjunction with iron has been studied over the last decade for the purpose of achieving well-functioning iron-based photosensitisers. This is based on the strong σ- donating ability of the carbene, and the effect this has on the metal-based orbitals of iron, for achieving more stable excited states. This work has been done to harness this earth-abundant metal

Stories of successful works have often dominated the history of Scandinavian encyclopedias. This is understandable given the rich encyclopedia tradition that characterizes the Scandinavian book market. Among the publications within this tradition, one encyclopedia stands out in particular. By being in print for more than sixty years, Salmonsens Konversationsleksikon had a special impact on the dev

Many modern city centres are struggling with the aftermath of car-centric and consumption-driven urban planning from the last century. This approach has led to widespread vacancies, a lack of green spaces, and unattractive public areas, that fail to offer diverse functions. While many cities have pedestrian-friendly zones, these areas are often dominated by retail spaces that cater primarily to co

The number of connected IoT devices increases rapidly and so do cyber threats against them. In contrast to high-end computers, IoT devices are extra vulnerable to threats since they many times don’t have the same defense mechanisms because of their limited resources. Intrusion detection systems (IDS) are typically used to monitor IoT devices externally on a server/client setup. The purpose of this

This chapter analyses the Spanish Habsburg crypt at the Escorial and the dynamics that caused it to become increasingly inclusive. Two main dynamics are identif ied: family heads exercising increased authority in mandating burials in the Escorial, including for individuals who had indicated other wishes, like siblings and adult children. And peripheral relatives who previously would not have expec