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Steroid hydroxylation using immobilized spores of Curvularia lunata germinated in situ

Spores of Curvularia lunata were immobilized in polyacrylamide granules and in calcium alginate beads (2–3 mm in diam.). Germination of the spores, initiated by the addition of nutrients, resulted in an even distribution of mycelium throughout the beads after 48 h. Such beads were used for the conversion of cortexolone to cortisol by steroid-11β-hydroxylation. In order to improve the steroid trans

Affinity Precipitation of Enzymes

This paper describes the preparation of a bifunctional NAD compound (Bis-NAD) and its properties as a complexing/precipitating agent for the tetrameric enzyme lactate dehydrogenase (LDH).

Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment

IMPORTANCE An accurate prognosis is especially pertinent in mild cognitive impairment (MCI), when individuals experience considerable uncertainty about future progression. OBJECTIVE To evaluate the prognostic value of tau positron emission tomography (PET) to predict clinical progression from MCI to dementia. DESIGN, SETTING, AND PARTICIPANTS This was a multicenter cohort study with external valid

Hypophosphatemia attenuates improvements in vitality after intravenous iron treatment in patients with inflammatory bowel disease

Purpose: Iron deficiency anemia is common in people with inflammatory bowel disease (IBD), causing deterioration in quality of life, which can be reversed by treatment that increases iron stores and hemoglobin levels. The present post hoc analyses estimate health state utility values for patients with IBD after treatment with ferric derisomaltose or ferric carboxymaltose and evaluate the health do

N-Doping Donor-Dilute Semitransparent Organic Solar Cells to Weaken Donor : Acceptor Miscibility and Consolidate Donor-Phase Continuity

Lightweight and semi-transparent organic solar cells (ST-OSCs) offer bright promise for applications such as building integrated photovoltaics. Diluting donor content in bulk-heterojunction active layers to allow greater visible light transmittance (AVT) effectively enhances device transparency, yet the ineluctable compromise of the donor-phase continuity is challenging for efficient charge transp

Probiotic-Reduced Inflammaging in Older Adults : A Randomized, Double-Blind, Placebo-Controlled Trial

The disparity between increased lifespan and healthy aging, marked by prevalent “inflammaging”, highlights the global challenge in care of older persons. This study explored the anti-inflammatory effects of Lactiplantibacillus plantarum HEAL9 (LpHEAL9), alone or combined with berries, on older volunteers with chronic low-grade inflammation (LGI). It was a randomized, double-blind, placebo-controll

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Background. Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods. These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl

Advancements and recent explorations of anti-cancer activity of chrysin : from molecular targets to therapeutic perspective

In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly in various plant sources like honey, propolis, and certain fruits and vegetables. This active compound has garnered significant attention due to its promising therapeutic qualities and minimal toxicity. CH’s ability to c

Expiratory and inspiratory resistance and reactance from respiratory oscillometry defining expiratory flow limitation in obstructive lung diseases

Background: Expiratory flow limitation (EFL) during tidal breathing and lung hyperinflation have been identified as major decisive factors for disease status, prognosis and response to therapy in obstructive lung diseases. Aim: To investigate the delta values between expiratory and inspiratory resistance and reactance, measured using respiratory oscillometry and its correlation with air trapping a

Temperature sensitivity of OH-lines in the H-band of K-M giants

To properly understand regions of space behind interstellar dust, like the Galactic bulge, infrared (IR) observations are needed, as it passes through the dust with minimal absorption. In the past few decades, the development of IR telescopes has allowed for a much deeper understanding of our Galaxy’s stellar populations and history. To properly use the data which these IR telescopes produce howev

Inter-organizational Data Sharing Processes – an exploratory analysis of incentives and challenges

Businesses across different areas of interest areincreasingly depending on data, particularly for machine learning (ML) applications. To ensure data provisioning, interorganizational data sharing is proposed, e.g. in the form of data ecosystems. The aim of this study was to perform an exploratory investigation into the data sharing practices that existin business-to-business (B2B) and business-to-

Adaptation to fluctuating temperatures across life stages in endotherms

Accelerating rates of climate change have intensified research on thermal adaptation. Increasing temperature fluctuations, a prominent feature of climate change, means that the persistence of many species depends on both heat and cold tolerance across the entire life cycle. In endotherms, research has focused on specific life stages, with changes in thermoregulation across life rarely being examin

Embedded eigenvalues for asymptotically periodic ODE systems

We investigate the persistance of embedded eigenvalues under perturbations of a certain self-adjoint Schrödinger-type differential operator in L2(R; Rn), with an asymptotically periodic potential. The studied perturbations are small and belong to a certain Banach space with a specified decay rate, in particular, a weighted space of continuous matrix valued functions. Our main result is that the se

Thromboembolic and bleeding risk in cardiac amyloidosis

Cardiac amyloidosis represents a spectrum of conditions characterized by the accumulation of insoluble fibrils, resulting in progressive deposition and myocardial dysfunction. The exact mechanisms contributing to the heightened risk of thromboembolic events and bleeding tendencies in cardiac amyloidosis remain unclear. Proteins such as transthyretin in transthyretin amyloidosis and light chains in

Ethical V2X: Cooperative Driving as the Only Ethical Path to Multi-Vehicle Safety

We argue that an information exchange between vehicles via the vehicular communications is the foundation for ethical driving. In other words – autonomous vehicles must be cooperative to be able to resolve ethical dilemmas in a multi-vehicle scenario. We show this by exploring the minimal setting of a longitudinal driving in a formation of three vehicles.

Cytology of thyroid and parathyroid glands in oncology diagnosis – a contemporary review of updates and innovations

Fine needle aspiration (FNA) is widely used in the examination of head and neck lesions and has been considered an important diagnostic tool in the evaluation of thyroid and parathyroid nodules. Thyroid nodules are frequent findings in the general population, although 90-95% of these nodules are benign. FNA plays a crucial role to determine which nodules are at greatest risk of malignancy and whic

Systems of rationalization : New methods and changes of organization in swedish building construction around 1970

This paper is a study of the implementations of two new working methods, systems construction and incentive contracts, in Swedish State building construction around 1970 with an analysis of the implication of such implementations on the organization of the building industry. Specifically, the study is focusing on the role of the architect in the building process of the National Board of Public Bui

The LuViRA Dataset: Synchronized Vision, Radio, and Audio Sensors for Indoor Localization

We present a synchronized multisensory dataset for accurate and robust indoor localization: the Lund University Vision, Radio, and Audio (LuViRA) Dataset. The dataset includes color images, corresponding depth maps, inertial measurement unit (IMU) readings, channel response between a 5G massive multiple-input and multiple-output (MIMO) testbed and user equipment, audio recorded by 12 microphones,

Epilogue

In three thematic sections and 18 different chapters, this volume has unpacked and explored the conditions, contexts, and practices of creative work from multiple different perspectives.

Alcohol production by magnetic immobilized yeast

Saccharomyces cerevisiae was immobilized in calcium alginate gel together with varying concentrations of iron oxide, in the form of magnetite or a colloidal ferrite suspension, Ferrofluid™. Inclusion of magnetic material apparently had no adverse effect on the yeast cells as judged from their fermentation capacity, their operational stability as well as their ability to propagatein situ in the pre