The development of melanocytes is regulated by the tyrosine kinase receptor c-KIT and the basic-helix-loop-helix-leucine zipper transcription factor Mitf. These essential melanocyte survival regulators are also well known oncogenic factors in malignant melanoma. Despite their importance, not much is known about the regulatory mechanisms and signaling pathways involved. In this study, we therefore

This paper extends earlier works on three-dimensional scattering from a finite obstacle in a stratified halfspace, treated by means of the T-matrix method. In this paper we consider a general source configuration above the ground, that excites the subsurface medium and its inhomogeneity. Explicit expressions are given for the magnetic dipole, the circular, and rectangular antenna loops. Numerical

PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified.

This thesis aims at describing the developmental patterns of text production in four text types: spoken and written narrative texts, and spoken and written expository texts (n=316), produced by four age groups: 10-year-olds, 13-year-olds, 17-year-olds and university students (n=79). It explores material from an experimental study with a cross-sectional design comprising spoken texts recorded on vi

Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the

During 2012 - 2013 a study to evaluate conventional X-ray procedures and patient doses in Klintzi and Novozibkov areas of Bryansk region, Russia, was conducted. X-ray operation parameters included quality assurance of equipment, collection of procedure parameters and clinical practice evaluation. Effective doses were calculated for each selected procedure and dose distributions were established. 7

The technology of today, with the use of computers and the Internet, has enabled new types of map usage. Screen maps provide possibilities that could never be offered by standard paper maps, and allow maps to be integrated into information services. Mobile map services are information services adapted to mobility; using small screen presentation devices and communication networks to access various

Information on mortality in ankylosing spondylitis (AS) is scarce. Our study therefore aimed to assess: (1) mortality in AS versus the general population, and (2) predictors of death in the AS population.

Objective. Formal joint assessments are critically important to improve rheumatological care of patients with RA. The aim of this study was to determine the usefulness of patient-recorded 28 tender joint counts (TJCs) and swollen joint counts (SJCs) using a tablet personal computer and to explore the possibility of using patient-recorded data to calculate 28-joint DAS (DAS-28) and EULAR response.

The introduction of Rituximab has greatly improved therapeutic options for patients with B-cell non-Hodgkin lymphoma (B-NHL). However, a substantial fraction of patients with aggressive B-NHL fails first-line therapy, and most patients with relapsing indolent B-NHL eventually acquire Rituximab resistance. Molecular understanding of the underlying mechanisms facilitates the development of pharmacol