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The development of multigene classifiers for cancer prognosis, treatment prediction, molecular subtypes or clinicopathological groups has been a cornerstone in transcriptomic analyses of human malignancies for nearly two decades. However, many reported classifiers are critically limited by different preprocessing needs like normalization and data centering. In response, a new breed of classifiers,

PURPOSE Periampullary adenocarcinomas encompass a heterogeneous group of tumors with dismal prognosisand limited treatment options. Emerging evidence shows that tumor morphology (ie, intestinal type [I-type] orpancreatobiliary type [PB-type]) is a more relevant prognostic factor than tumor origin. Knowledge is sparse,however, on whether key mutations differ according to morphology.MATERIALS AND ME

The project is part of the Geoinfra TRUST framework that is working towards developing techniques for more cost efficient and sustainable underground construction in urban areas (see http://trust-geoinfra.se/ for more information). This project aims at development and adaptation of DCIP (DC resistivity and induced polarisation) imaging for use in urban environments, and includes demonstration and

I Naturvårdsverkets miljömålsuppföljning från 2013 slås det fast att förorenat grundvatten utgör ett nationellt problem. Det konstateras vidare att uppföljningen och övervakning-en av förorenat grundvatten är otillräcklig, något som även uppmärksammats i EUs vattendirektivsuppföljning (2012). Förekomsten av förorenande ämnen i svenska grundvatten-magasin behöver utredas bättre, inte minst för att

Acquired mutations in TP53 as well as immunohistochemically detectable protein expression have been implicated as prognostic factors for breast cancer. We have evaluated the relationship between mutations detected in 119 breast tumours and various clinicohistopathological indices, stratifying the mutations according to the functional domains as defined by the recent elucidation of the crystal stru

Unforeseen ground conditions are risk factors often leading to delays and significant additional costs in conjunction with underground infrastructure construction work. There are two main geological hazards that are important to identify, manage, or possibly avoid, for safe and efficient underground construction. The first is unstable rock and the second is large groundwater inflow. The latter exi

Transcript variants of the estrogen receptor (ER) were investigated in 109 primary breast tumors using reverse transcription-polymerase chain reaction (RT-PCR) and primers allowing analysis of each internal exon. A high incidence of different ER variants was observed, each individual tumor often manifesting multiple variants coexisting with corresponding wildtype (wt) ER. These variants, by sequen

Thirty tumors from metastatic breast cancer patients were screened for mutations in the estrogen receptor (ER) gene using single-strand conformation polymorphism and sequence analysis. Three missense mutations, Ser47Thr, Lys531Glu, and Tyr537Asn, were identified in these lesions. To investigate these mutated ERs or altered transcriptional activation function, expression vectors containing wild-typ

The best current model of breast cancer evolution suggests that most cancers arise from certain premalignant lesions. We have identified a common (34%) somatic mutation in the estrogen receptor (ER)-alpha gene in a series of 59 typical hyperplasias, a type of early premalignant breast lesion. The mutation, which affects the border of the hinge and hormone binding domains of ER-alpha, showed increa

Den här rapporten innehåller en sammanställning av abstracts som ligger till underlag för de presentationer som presenterades på konferensen Grundvattendagarna i Lund den 16–17 oktober 2013. Konferensen anordnades av SGU i samarbete med Geologiska institutionen på Lunds uni-versitet och Länsstyrelsen Skåne. Ett av konferensens syften var att få till en bred uppslutning från olika organisationer, m

The Congress "Arsenic in the Environment" offers an international, multi- and interdisciplinary discussion platform for research and innovation aimed towards a holistic solution to the problem posed by the environmental toxin arsenic, with considerable societal impact. The congress has focused on cutting edge and breakthrough research in physical, chemical, toxicological, medical, agricultural and

Vatten är en naturresurs som vi kanske tar lite för mycket för givet i vårt land. Grundvattenforskaren charlotte Sparrenbom menar att skyddet av den kanske viktigaste naturresursen för vår överlevnad är kraftigt eftersatt. hon vill väcka till eftertanke om hur vårt fotavtryck ser ut för kommande generationer, och föreslå sätt att komma igång med bättre skydd av vårt vatten.

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In this paper, I give a short description of a language change that can be viewedas an instance of grammaticalization, namely the transition of the two adjectivesmycken/t and liten/t into quantifiers. Data from the corpus of Swedish drama dialogue reveal that liten/t became a quantifier as early as the 1700s, whereas mycken/t seems to have gone through the same change roughly 150 years later. Inhe