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Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma.

The newly identified protein BLAP75/RMI1 associates with the helicase BLM and is critical for the function of the homologous recombination complex. Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom's syndrome). We have analyzed the common polymorphism Ser455Asn in RMI1 and its association with cancer risk in acute myeloid leukemia (AML, N=93), myelody

Femoral Neck Bone Strength Estimated by Hip Structural Analysis (HSA) in Swedish Caucasians Aged 6-90 Years.

Dual-energy X-ray absorptiometry hip scans of 1,760 population-based Caucasians, 599 girls and 642 boys aged 6-19 years and 270 women and 249 men aged 20-90 years, were analyzed with the hip structural analysis (HSA) software to present age- and sex-specific normative HSA data of the femoral neck (FN). Measured traits included bone mineral density (BMD), cross-sectional area (CSA), section modulus

Mental workload in basic civil aviation training

Although the aviation industry has gone through great technological and commercial change in the last decades, basic civil aviation training has not changed accordingly. The consequences of the changes in civil aviation have rarely resulted in research programs in the field of basic civil aviation training and this phase, where future pilots gain their first sets of skills and knowledge, has long

Activity of pyramidal tract neurons in the cat during standing and walking on an inclined plane.

To keep balance when standing or walking on a surface inclined in the roll plane, the cat modifies its body configuration so that the functional length of its right and left limbs becomes different. The aim of the present study was to assess the motor cortex participation in the generation of this left/right asymmetry. We recorded the activity of fore- and hindlimb-related pyramidal tract neurons

Expressing and Examining Morality in Everyday Life: Social Comparisons among Swedish Parents of Deaf Children

Social comparisons, seeing oneself in relation to others, are universal, common, and perhaps even necessary. In a study of parents of deaf children, intense, open, and mutual examinations were voiced in parental groups, meetings between parents and professionals, and interviews. These comparisons were generated in a specific situation created by successful claims for separate milieus advocated by

Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity.

BACKGROUND: The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation. OBJECTIVE: The aim was to examine whether dietary factors (macronutrient and fiber intakes) and leisure-time physical activity modify the association between genetic variation in FTO and body mass index (BMI; in kg/m(2)). DESIGN: A cross-sectional study exam

Why Israel Is Obsessed with an Iranian Bomb

Israeli leaders constantly imagine themselves in the shoes of their Iranian counterparts and invariably conclude that it is only rational for the Islamic Republic to acquire the bomb.

Impact of antenna design on MIMO performance for compact terminals with adaptive impedance matching

Using the metrics of channel capacity and multiplexing efficiency, the adaptive impedance matching (AIM) performances of two multiple-input multiple-output (MIMO) terminals with different antenna designs were evaluated and compared. The evaluation was performed in LTE Band 18 Downlink (860-875 MHz) under realistic usage conditions of two measured user handgrips and simulated propagation channels w

Convergent evolution in aquatic tetrapods: insights from an exceptional fossil mosasaur.

Mosasaurs (family Mosasauridae) are a diverse group of secondarily aquatic lizards that radiated into marine environments during the Late Cretaceous (98-65 million years ago). For the most part, they have been considered to be simple anguilliform swimmers--i.e., their propulsive force was generated by means of lateral undulations incorporating the greater part of the body--with unremarkable, dorso

Healthcare costs for people aged 65+ two years prior to their receiving long-term municipal care.

BACKGROUND AND AIMS: More knowledge is needed about patterns of healthcare consumption at different times during old age, particularly with regard to the relationship between various agents in the healthcare and social services system. One aim was to investigate healthcare costs in the public medical healthcare system in men and women (65+) and, with regard to age, in the two years prior to the st

Child Neurodevelopmental and Behavioural Problems are Intercorrelated and Dimensionally Distributed in the General Population

The Autism – Tics, AD/HD, and other Comorbidities inventory (A-TAC) is a comprehensive interview for evaluating problems related to autism spectrum disorders (ASD), tic disorders, attention-deficit/hyperactivity disorder (AD/HD), and common comorbid conditions in children and adolescents. A-TAC telephone interviews were administered to parents of 2,957 children aged nine- or twelve-years, represen

Time-resolved and Wavelength-resolved Spectroscopy In 2-photon-excited Fluorescence Microscopy

Two-photon excited fluorescence spectroscopy has been performed at a microscopic scale in combination with normal, white-light microscopy. This gave simultaneously a spectral resolution of 20 nm and a temporal resolution of 20 ps, from a volume element less than 5 mu m in all three dimensions. The sample was excited with the light from a continuously mode-locked Ti:sapphire laser that was focused