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Determination of left ventricular long-axis orientation using MRI: changes during the respiratory and cardiac cycles in normal and diseased subjects

Background: It has previously been shown that magnetic resonance imaging (MRI) can be used to accurately determine left ventricular (LV) long-axis orientation in healthy individuals. However, the inter- and intra-observer variability in patients with acute coronary syndrome (ACS) and chronic heart failure (CHF) has not been explored. Furthermore, the changes in LV long-axis orientation because of

Interactions between Surfaces in Polydisperse Semiflexible Polymer Solutions

We generalize a recently developed polymer density functional theory (PDFT) for polydisperse polymer fluids to the case of semiflexible (stiff) polymers. As with our earlier work on flexible polymers, we show here that the generalization of the PDFT to polydisperse: mixtures of semiflexible chains allows us to obtain a remarkable simplification of the solution algorithm, compared to the monodisper

Evaluation of usage-based reading - Conclusions after three experiments

Software inspections have been introduced in software engineering in order to detect faults before testing is performed. Reading techniques provide reviewers in software inspections with guidelines on how they should check the documents under inspection. Several reading techniques with different 16 purposes have been introduced and empirically evaluated. In this paper, we describe a reading techni

Patients' needs during the year after a suicide attempt A secondary analysis of a randomised controlled intervention study.

OBJECTIVE: We first studied whether changes of needs were influenced by randomly allocated telephone interventions between 1 and 12 months after a suicide attempt in addition to treatment as usual. These were aimed at improving motivation for professional treatment. As a secondary analysis we investigated the frequency and changes of needs during this period and if changes were related to other ou

Sustained reduction of antibiotic use and low bacterial resistance: 10-year follow-up of the Swedish Strama programme

Increasing use of antibiotics and the spread of resistant pneumococcal clones in the early 1990s alarmed the medical profession and medical authorities in Sweden. Strama (Swedish Strategic Programme for the Rational Use of Antimicrobial Agents and Surveillance of Resistance) was therefore started in 1994 to provide surveillance of antibiotic use and resistance, and to implement the rational use of

Molecular characterization of protein Sir, a streptococcal cell surface protein that binds both immunoglobulin A and immunoglobulin G

Cell surface proteins that bind to the Fc part of immunoglobulin (Ig) A and/or IgG are expressed by many strains of the group A Streptococcus, an important human pathogen. Two extensively characterized proteins in this group of molecules are protein Arp that preferentially binds IgA and protein H that binds IgG. In addition, recent work has shown that many group A streptococcal strains express a n

Possible evidence for the ejection of a supermassive black hole from an ongoing merger of galaxies

Attempts of Magain et al. to detect the host galaxy of the bright quasi-stellar object (QSO) HE0450-2958 have not been successful. We suggest that the supermassive black hole (SMBH) powering the QSO was ejected from the observed ultraluminous infrared galaxy (ULIRG) at the same redshift and at 1.5 arcsec distance. Ejection could have been caused either by recoil due to gravitational wave emission

Novel "plum pudding" as potential drug-eluting stent coatings : Controlled release of fluvastatin

This study evaluated novel structural motifs known as "plum pudding" gels as potential drug-eluting stent coatings. Controlled delivery of a HMG-CoA reductase inhibitor (statin) from the intravascular stent surface represents a potential therapeutic modality for prevention of in-stent restenosis (ISR). In this study, gels were comprised of fluvastatin-loaded thermoresponsive microgel particles con

Comparison of genotyping methods by application to Salmonella livingstone strains associated with an outbreak of human salmonellosis

During 2000 and 2001, an outbreak of human salmonellosis occurred in Sweden and Norway, caused by Salmonella livingstone. In this study, the genotypic differences between three strains obtained from food sources during the outbreak, two human strains and 27 more or less unrelated strains were analysed, using the three methods; automated ribotyping, pulsed field get electrophoresis (PFGE) and rando

A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control

Ghrelin is a 28 a.a. gastric peptide, recently identified as a natural ligand of the growth hormone secretagogue receptor (orphan receptor distinct from the receptor fur growth hormone releasing hormone). In the present study. radioimmunoassay demonstrated ghrelin-like material in the rat oxyntic mucosa with moderate amounts also in antrum and duodenum. Small amounts: were found in the distal inte

Technological Change Around the World: Evidence from Heart Attack Care

Although technological change is a hallmark of health care worldwide, relatively little evidence exists on whether changes in health care differ across the very different health care systems of developed countries. We present new comparative evidence on heart attack care in seventeen countries showing that technological change—changes in medical treatments that affect the quality and cost of care—

Microsatellite markers in a complex of Horismenus sp. (Hymenoptera : Eulophidae), parasitoids of bruchid beetles

Parasitoids of the genus Horismenus (Hymenoptera: Eulophidae) are the main natural enemies of bruchid beetles that feed on several species of Phaseolus beans. Samples of Horismenus depressus, H. missouriensis and H. butcheri were collected from seeds of three Phaseolus species throughout Mexico to examine the impact of plant variability on the genetic structure of parasitoid populations. For this

Real options valuation principle in the multi-period base-stock problem

This paper analyzes the multi-period base-stock problem where there is a financial risk associated with a stochastic demand. For the single-period problem, it is known that the optimal inventory policy can be obtained with the Black and Scholes option pricing formula. This paper pushes the analysis further by applying the options valuation framework to the multi-period problem and presenting an al

Transient Aggregates in Protein Folding are Easily Mistaken for Folding Intermediates

It has been questioned recently whether populated intermediates are important for the protein folding process or are artefacts trapped in nonproductive pathways. We report here that the rapidly formed intermediate of the spliceosomal protein U1A is an off-pathway artefact caused by transient aggregation of denatured protein under native conditions. Transient aggregates are easily mistaken for stru