Methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a new drug target that is expressed in cancer cells but not in normal adult cells, which provides an Achilles heel to selectively kill cancer cells. Despite the availability of crystal structures of MTHFD2 in the inhibitor- and cofactor-bound forms, key information is missing due to technical limitations, including (a) the location

Sustainability footprints are caused by semiconductor malfunctioning; production challenges (low yield) and customer returns (wear-out). We work with standards, techniques, and methods to quickly and accurately pin-point and mitigate malfunctioning aiming at graceful degradation to prolong operational lifetime.

Denna artikel diskuterar arkivkällor med känslig information och behovet av olika etiska angreppssätt. Avsikten med att lyfta dessa frågor är att frambringa en diskussion om hur historiker kan arbeta med känsligt material på ett etiskt sätt. Artikeln lyfter fram främst tre begrepp: processetik, omsorgsetik och dygdetik.In comparison to disciplines within the humanities and social sciences working directly with living humans, as well as in comparison to oral history, historians primarily working with archival sources lack a living discussion on ethics in connection with our methods. At the same time, archival sources that contain sensitive personal information are central in many fields – such as queer history –

Background: Smoking cessation may be very difficult, even if smoking aggravates the prognosis of a disease, which has been shown to be the case for persons with rheumatoid arthritis (RA). In contrast, an association in patients with osteoarthritis (OA) is still disputed. The primary objective was to compare smokers diagnosed with RA and OA to controls, regarding smoking cessation rates after follo

Introduction: Atopic asthma and allergic rhinitis are common chronic inflammatory diseases affecting lower airways and nasal mucosa, respectively. Several reports demonstrated frequent co-occurrence of these two diseases, however, the exact molecular mechanism has not been described. The present study aimed to investigate if small non-coding RNA might be responsible for the co-occurrence of asthma

Lung transplantion (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic rejection of a lung allograft. There is great clinical need for a minimally invasive biomarker of BOS. Here, 644 different proteins were analyzed to detect biomarkers that distinguish BOS grade 0 from grades 1-3. The plasma

Most scholars attribute the development and ubiquity of global value chains to economic forces, treating law as an exogenous factor, if at all. By contrast, we assert the centrality of legal regimes and private ordering mechanisms to the creation, structure, geography, distributive effects and governance of Global Value Chains (GVCs), and thereby seek to establish the study of law and GVCs as rich

The Accord on Fire and Building Safety in Bangladesh (the Accord) is generally seen as a positive development in ensuring that Bangladeshi garment industry workers have access to safe working conditions. A central structural difference between the Accord and earlier corporate social responsibility (CSR) initiatives is that the Accord takes the form of an enforceable contract that directly connects

Global value chains (‘GVCs’) have become a basic operative unit of economic production. Their development over the twentieth and twenty-first centuries has resulted in immense creation of wealth while linking together individuals, companies and economies across the world. But GVCs are also a major cause for environmental degradation, carbon emissions and human rights abuses—the ‘externalities’ of

Conceptualizing how private actors can and should control their supply chains is a tricky question with both economic and legal dimensions. The topic is of extreme importance in today's global economy. On the one hand, this importance is highlighted by events such as the catastrophic and deadly collapse of the Rana Plaza factory building in Bangladesh and the economic fiasco of the Olkiluoto 3 nuc

Contracts are used to extend governance on supply chain and platform actors in ways that could not be envisaged when the foundations of current conceptualizations of contractual privity were laid down in the 19th century. This results in a stark contradiction. Firms use contracts to extend governance on actors beyond privity when it suits their interests, for example for reasons of supplychain-wid

The public management of urban space is an everyday practice that requires development. But how is creative work done in a public context? The idea of offering outdoor offices and outdoor conferences is being implemented in an open-air museum, owned by a middle-sized city in Sweden. This chapter focuses on their ambitions to be innovative, and the practices officials engage in, to innovate. The et