Sustainable business model innovation is about creating superior customer and firm value by addressing societal and environmental needs through the way business is done. Business models require intentional design if they are to deliver aspired sustainability impacts. Scant research has been done on ‘ecologies’ of different business models in order to understand and improve these and create positiv

Nanowire array solar cells have reached efficiencies where it becomes feasible to talk about creating tandem solar cells in order to achieve even higher efficiencies. An example of such a tandem solar cell could be a nanowire array embedded in a membrane and integrated on top of a Si bottom cell. Such a system, however, requires understanding and control of its interaction with light, especially t

Modern transportation requires advanced powertrain systems to reduce the production of greenhouse gas CO2. Partially premixed combustion (PPC) is one of the most promising methods to achieve low emission and low fuel consumption of internal combustion engines. The present paper evaluated the effects of the calibration parameters on the efficiency and emissions of a multi-cylinder engine using PPC

Many of the basic ideas in multiparton interaction (MPI) phenomenology were first developed in the context of the Pythia event generator, and MPIs have been central in its modeling of both minimum-bias (MB) and underlying-event physics in one unified framework. This chapter traces the evolution towards an increasingly sophisticated description of MPIs in Pythia, including topics such as the orderi

The aim of this study is to explore the links between modal options and opportunities to participate in everyday activities among people aged 65–79 and living in Sweden's large metropolitan regions (Stockholm, Gothenburg and Malmö). This incorporated a specific focus on those considered at a greater risk of transport-related social exclusion. This study applies the Capability Approach as a concept

We describe the DIPSY model for initial state evolution and the implementation of this in an event generator for producing fully exclusive hadronic final states. The model is formulated in impact parameter space and rapidity. Including non-leading and nonlinear effects, it gives a unique picture of fluctuations and correlations in the initial state parton evolutions. It also gives an impact-parame

A metaphyseal bone defect due to infection, tumor or fracture leads to loss of cancellous and cortical bone. An animal model separating the cancellous and cortical healing was used with a combination of a macroporous gelatin-calcium sulphate-hydroxyapatite (Gel-CaS-HA) biomaterial as a cancellous defect filler, and a thin collagen membrane (CM) guiding cortical bone regeneration. The membrane was

Formation of partially constrained precipitates such as hydride blisters and oxide nodules have been reported on surfaces of Zr-alloy components of pressurised heavy water reactors and is associated with a large increase in volume. Such a change in volume imposes large stresses in the material surrounding the precipitate and may facilitate stable crack growth through delayed hydride cracking. In t

BACKGROUND:: There is a lack of knowledge about how the provision and availability of specialized palliative care relates to the quality of dying in hospital and community-based settings. AIM:: We aimed to explore the quality of care during last week of life in relation to different levels of palliative care development. DESIGN:: We investigated access to palliative care in Southern Sweden, where

Context: Epigenetics may contribute to sex-specific differences in human liver metabolism. Objective: To study the impact of sex on DNA methylation and gene expression in human liver. Design/Setting: Cross-sectional, Kuopio Obesity Surgery Study. Participants/Intervention: We analyzed DNA methylation with the Infinium HumanMethylation450 BeadChip in liver of an obese population (34 males, 61 femal

Coiled-coil domains of intermediate filaments (IF) and prokaryotic IF-like proteins enable oligomerisation and filamentation, and no additional function is ascribed to these coiled-coil domains. However, an IF-like protein from Streptomyces reticuli was reported to display cellulose affinity. We demonstrate that cellulose affinity is an intrinsic property of the IF-like proteins FilP and Scy and t

En del moraliska dilemman och samhällsproblem uppstår ur många sinsemellan orelaterade individuella handlingar eller underlåtelser, samtidigt som problemen bara kan åtgärdas genom kollektiv handling. Vi kritiserar tre sätt att resonera om ostrukturerade gruppers moraliska plikter och ansvar i sådana situationer. Därefter föreslår vi att intuitionen att en sådan grupp kan ha moraliska plikter och v

The prognosis of triple-negative breast cancer with metastases after chemotherapy remains dismal. We report the case of a 50-year-old female with first disease recurrence at the axillary lymph node and, later on, bilateral pulmonary metastases with severe shortness of breath. The patient received low-dose immune checkpoint blockade (concurrent nivolumab and ipilimumab) weekly over 3 weeks with reg

Objective: Hyperglycaemia during pregnancy increases the risk of adverse health outcomes in mother and child, but the genetic aetiology is scarcely studied. Our aims were to (1) assess the overlapping genetic aetiology between the pregnant and non-pregnant population and (2) assess the importance of genome-wide polygenic contributions to glucose traits during pregnancy, by exploring whether geneti

Background: Substance-related addictive disorders are known to be overrepresented in non-heterosexual individuals, but it is largely unknown whether this is also the case for behavioral addictions such as problem gaming and gambling. This study aimed, in a pilot web survey design, to assess whether problematic gambling, gaming and internet use may be more common in individuals with a non-heterosex

OBJECTIVE: To examine the clinical phenotype, gray matter atrophy patterns, and small vessel disease in patients who developed prodromal or probable Alzheimer disease dementia, despite carrying the protective APOEε2 allele. METHODS: We included 36 β-amyloid-positive (by CSF or PET) APOEε2 carriers (all ε2/ε3) with mild cognitive impairment or dementia due to Alzheimer disease who were matched for

BACKGROUND: In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression was inversely correlated with patient survival. The aim of the study was to further validate the prognostic significance of CLCA1 in pancreatic cancer. METHODS: CLCA1 expression was

OBJECTIVES: To compare and examine whether, when and how patients with lung cancer in three countries, with different survival rates, talk about cigarette smoking and its relationship with help-seeking. DESIGN: A qualitative cross-country comparison with analysis of narrative interviews. SETTING: Participants in Sweden, Denmark and England were interviewed during 2015-2016. Interviews, using a nar

Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal structure of human AQP10 determined at 2.3 Å resolution unveils the molecular basis for pH modulatio