Glycans are biologically important structures synthesised by glycosyltransferase (GT) enzymes. Disruptive genetic null variants in GT genes can lead to serious illness but benign phenotypes are also seen, including antigenic differences on the red blood cell (RBC) surface, giving rise to blood groups. To characterise known and potential carbohydrate blood group antigens without a known underlying

The Northern Hemisphere experienced dramatic changes during the last glacial, featuring vast ice sheets and abrupt climate events, while high northern latitudes during the last interglacial (Eemian) were warmer than today. Here we use high-resolution aerosol records from the Greenland NEEM ice core to reconstruct the environmental alterations in aerosol source regions accompanying these changes. S

Genome editing has proven to be highly potent in the generation of functional gene knockouts in dividing cells. In the CNS however, efficient technologies to repair sequences are yet to materialize. Reprogramming on the mRNA level is an attractive alternative as it provides means to perform in situ editing of coding sequences without nuclease dependency. Furthermore, de novo sequences can be inser

Background: Many stroke survivors suffer from sensory impairments of their affected upper limb (UL). Although such impairments can affect the ability to use the UL in everyday activities, very little attention is paid to sensory impairments in stroke rehabilitation. The purpose of this trial is to investigate if sensory re-learning in combination with task-specific training may prove to be more ef

OBJECTIVE: Sexually transmitted diseases and unplanned pregnancies are social and health issues among Icelandic teenagers and are more prevalent than in neighbouring countries. In 2001 knowledge and attitudes to sexual education, sexually transmitted disease and contraception among 16-year olds were investigated by questionnaire. Knowledge was defective. The study was repeated in 2005-2006 in a la

Actinomycosis is an infectious disease that has been known since the late nineteenth century. In the pre-antibiotic era it was thought to be rather common but with increased use of antimicrobial agents its incidence has decreased significantly. The causative agent, most commonly Actinomyces israelii, is part of the commensal bacterial flora. It can infect any tissue, respects no tissue boundaries

BACKGROUND: Refractory neuropathic inguinodynia following inguinal herniorrhaphy is a common and debilitating complication. This prospective study evaluated long-term outcomes associated with laparoscopic retroperitoneal triple neurectomy.METHODS: Sixty-two consecutive patients (51 male; mean age, 47); all failing pain management; prior reoperation in 35, prior neurectomy in 26; average follow-up

As a therapeutic technique, psychoanalysis had variable but at times spectacular results, as depicted in the film A Dangerous Method (2011). Starting as a clinical practice, psychoanalysis developed a theory of the unconscious that encompasses a wide range of phenomena, both normal and pathological, by problematizing the former and normalizing the latter. More generally psychoanalysis developed a

Vitiation refers to the condition where the oxygen concentration in the air is reduced due to the mix of dilution gas. The vitiation effects on a premixed methane flame were investigated on a swirl-stabilized gas turbine model combustor under atmospheric pressure. The main purpose is to analyze the combustion stability and CO emission performance in vitiated air and compare the results with the fl

This paper presents a numerical method to evaluate the electromagnetic radiating characteristics of a large-scale phased antenna array by using generalized transition matrix modules. Choosing an appropriate reference surface to contain an antenna element, an associated generalized transition matrix (GTM) is defined to establish the relationships between the rotated tangential components of inciden

Time-domain generalized transition matrix (TD-GTM) based on the time-domain integral equations (TDIEs) is implemented in this letter. The TD-GTM is established on the reference Huygens surface that encloses the object, using the impulse responses obtained by the marching-on-in-time (MOT) solutions. The TD-GTM fulfills the domain decomposition of TDIEs naturally and flexibly. It allows us to analyz

Models predicting ecosystem carbon dioxide (CO2) exchange under future climate change rely on relatively few real-world tests of their assumptions and outputs. Here, we demonstrate a rapid and cost-effective method to estimate CO2 exchange from intact vegetation patches under varying atmospheric CO2 concentrations. We find that net ecosystem CO2 uptake (NEE) in a boreal forest rose linearly by 4.7

The institution ‘Barnahus’ [Children’s House] have been established in the Nordic countries in purpose to improve the investigations and collaboration of involved agencies in protecting children in suspicion of being victims of serious crimes of abuse. Sometimes children visit Barnahus with their parents. In Sweden when custodians or related persons are suspected, children can be summoned to Barna

This article explores Sweden’s multiple roles in foreign policy in relation to its actions as an EU member state, seeking also to contribute to the understanding of small-state roles and behaviour at the dawn of a new age of uncertainty in Europe. Based on analytical tools derived from role theory within foreign policy analysis, as well as European integration theory, the article presents an analy

We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional conne

Background: Heparin-binding protein (HBP) is a neutrophil-derived protein advocated as a biomarker in sepsis. We evaluated plasma HBP as a predictor of post-injury sepsis in trauma patients. Methods: Ninety-seven trauma patients were studied during the first week of intensive care. Injury-related data were collected and clinical parameters registered daily. Plasma HBP was sampled on day 1, 3 and 5

The medical professions will lose an indispensable tool in clinical practice if even simple infections cannot be cured because antibiotics have lost effectiveness. This article presents results from an exploratory enquiry into “good doctoring” in the case of antibiotic prescribing at a time when the knowledge base in the healthcare field is shifting. Drawing on in-depth interviews about diagnosing

A search for heavy resonances decaying into a pair of Z bosons leading to ℓ+ℓ-ℓ+ℓ- and ℓ+ℓ- final states, where ℓ stands for either an electron or a muon, is presented. The search uses proton–proton collision data at a centre-of-mass energy of 13 TeV corresponding to an integrated luminosity of 36.1 fb - 1 collected with the ATLAS detector during 2015 and 2016 at the Large Hadron Collider. Differe