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Large-bias spectroscopy of Yu-Shiba-Rusinov states in a double quantum dot
We have performed tunnel transport spectroscopy on a quantum dot (QD) molecule proximitized by a superconducting contact. In such a system, the scattering between QD spins and Bogoliubov quasiparticles leads to the formation of Yu-Shiba-Rusinov (YSR) states within the superconducting gap. In this work, we investigate interactions appearing when one- and two-electron spin states in a double-QD ener
Burden of established cardiovascular disease in people with type 2 diabetes and matched controls : Hospital-based care, days absent from work, costs and mortality
Aims: To assess hospital-based care, work absence, associated costs, and mortality in patients with type 2 diabetes with and without established cardiovascular disease (eCVD) compared to matched controls. Materials and methods: In a population-based cohort study, we analysed individual-level data from national health, social insurance and socio-economic registers for people diagnosed with type 2 d
Design, synthesis, And applications of galectin modulators in human health
Over the last decade, the family of galectin proteins has been identified as key regulators of important biological processes. They bind β-D-galactopyranoside residues in glycoconjugates, and by presenting multiple binding sites, within one galectin or by forming dimers or multimers, they can cross-link glycoproteins and form galectin-glycoprotein lattices. Such lattices formed on the cell surface
Surface characterization and analysis of textured injection moulded PC-ABS automotive interior components
Automotive interior components are produced by injection moulding due to its cost effectiveness in mass production. The surfaces of these components are textured to control the appearance and other surface functional properties such as wear and scratch resistance. Key challenges lie in replicating the features of mould tool with high aspect ratio which are influenced by the polymer and large numbe
A dose planning study for cardiac and lung dose sparing techniques in left breast cancer radiotherapy : Can free breathing helical tomotherapy be considered as an alternative for deep inspiration breath hold?
Purpose: To investigate the possibility to be able to offer left sided breast cancer patients, not suitable for DIBH, an organ at risk saving treatment. Materials and Methods: Twenty patients receiving radiotherapy for left breast cancer in DIBH were enrolled in the study. Planning CT scans were acquired in the same supine treatment position in FB and DIBH. 3DCRT_DIBH plans were designed and optim
Lignin recovery from cocoa bean shell using microwave-assisted extraction and deep eutectic solvents
Lignin is the second most abundant natural polymer after cellulose, and valorisation of lignin-rich streams has attracted increasing attention recently. This paper presents a novel and sustainable method to recover lignin from Cocoa Bean Shells (CBS) using Deep Eutectic Solvents (DES) and microwaves. A DES containing p-toluenesulfonic acid, choline chloride and glycerol (2:1:1 M ratio) was selecte
Second-hand clothing markets and a just circular economy? Exploring the role of business forms and profit
Second-hand consumption of clothing can support the transition to circular economies by prolonging the lifespan of products through reuse. Historically, not-for-profit businesses have been dominant actors in second-hand markets across Western Europe and North America. However, with the growing interest in second-hand consumption, for-profit firms have increasingly entered this market over the last
Isothiazolinone inhibition of soil microbial activity persists despite biocide dissipation
Soil microbial growth and activity are generally assumed to recover rapidly after dissipation of organic toxicants. We studied the effects of four readily degradable isothiazolinone biocides (benzisothiazolinone, BIT; methylisothiazolinone, MIT; octylisothiazolinone, OIT; 4,5-dichloro-2-octyl-isothiazolinone, DCOIT) on bacterial growth, fungal growth, basal respiration, and substrate-induced respi
The characteristics of Michelin-starred restaurants in Mainland China, Hong Kong, Macau, and Taiwan
Chinese culinary culture has a long history of development and has unique characteristics, attracting people from all over the world. As a world-renowned restaurant award, the Michelin Guide in China plays an influential role in introducing Chinese culinary culture to the world and destination branding, while few studies have investigated Michelin-starred restaurants (MSRs) in China. This study th
Spatial inequality and housing in China
This paper investigates the evolution of inequality in China (1978–2015) through the lens of a dynamic spatial general equilibrium model with migration and capital formation. Due to an urban-rural income gap there is domestic migration from the rural to the urban areas which tends to reduce inequality. The resulting increase in urban house prices can, however, constitute an endogenous barrier to f
Application of a Magnetic-field-induced Transition in Fe x to Solar and Stellar Coronal Magnetic Field Measurements
Magnetic fields play a key role in driving a broad range of dynamic phenomena in the atmospheres of the Sun and other stars. Routine and accurate measurements of the magnetic fields at all the atmospheric layers are of critical importance to understand these magnetic activities, but in the solar and stellar coronae such a measurement is still a challenge due to the weak field strength and the high
7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection
An explorative study of inflammation-related proteins associated with kidney injury in male heat-stressed workers
Chronic kidney disease of non-traditional origin (CKDnt) and acute kidney injury (AKI) often affect heat-stressed Mesoamerican manual workers. Inflammation occurs concurrently with AKI in this population, but its role remains unknown. To explore links between inflammation and kidney injury in heat stress, we compared levels of inflammation-related proteins in cutters with and without increasing se
Uptake and use of biodiversity offsetting in urban planning – The case of Sweden
Globally, biodiversity offsetting is used to balance negative impacts on biodiversity and ecosystem services caused by exploitation. In Sweden, there is an increasing interest in biodiversity offsetting in urban planning. However, there is limited understanding about the use of the concept in a municipal context. This study aims to examine and critically reflect on the uptake and use of biodiversi
Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices
Tissue clearing is commonly used for whole-brain imaging but seldom used for brain slices. Here, we present a simple protocol to slice, immunostain, and clear sections of adult rat brains for subsequent high-resolution confocal imaging. The protocol does not require toxic reagents or specialized equipment. We also provide instructions for culturing of rat brain slices free floating on permeable cu
SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD
SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYLD with the linear ubiquitylation assembly complex (LUBAC) component HOIP. Whether SPATA2 exhibits functions independently of CYLD is unclear. Here, we show that, while Cyld−/− and Spata2−/− mice are viable, double mutants exhibit highly penetrant perinatal lethality, indicating independent functi
B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors
Induced pluripotent stem cell (iPSC) reprogramming is inefficient and understanding the molecular mechanisms underlying this inefficiency holds the key to successfully control cellular identity. Here, we report 24 reprogramming roadblock genes identified by CRISPR/Cas9-mediated genome-wide knockout (KO) screening. Of these, depletion of the predicted KRAB zinc finger protein (KRAB-ZFP) Zfp266 stro
Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease
Introduction: Plasma-measured tau phosphorylated at threonine 217 (p-tau217) is a potential non-invasive biomarker of Alzheimer's disease (AD). We investigated whether plasma p-tau217 predicts subsequent cognition and positron emission tomography (PET) markers of pathology in autosomal dominant AD. Methods: We analyzed baseline levels of plasma p-tau217 and its associations with amyloid PET, tau P
Selectively bred rodent models for studying the etiology of type 2 diabetes : Goto-Kakizaki rats and Oikawa-Nagao mice
Type 2 diabetes (T2D) is a polygenic disease and studies to understand the etiology of the disease have required selectively bred animal models with polygenic background. In this review, we present two models; the Goto-Kakizaki (GK) rat and the Oikawa-Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mouse. The GK rat was developed by continuous selective breeding for glucose tolerance f