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Climate change effects on marine species across trophic levels
Climate change and anthropogenic activities are producing a range of new selection pressures, both abiotic and biotic, on marine organisms. While there are numerous studies that have investigated the response of individual marine organisms to climate change, few studies have focused on differences in organismal responses across trophic levels. Such trophic differences in response to climate change
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which may influence responses to infection and vaccination. For an improved understanding of inter-individual differences in antibody responses, we isolated SARS-CoV-2 spike-specific monoclonal antibodies from convalescent h
8-band k · p modeling of strained InxGa(1-x)As/InP heterostructure nanowires
An 8-band k · p theory is implemented for studying the electronic properties of near-surface lateral InxGa(1-x)As/InP heterostructure nanowires in the (100) direction. The change in bandgap and effective mass due to inhomogeneous strain are compared to unstrained scenario nanowires, and the lattice mismatch is varied from -3.2% to 1%. The nanowires' height is H = 5, 13 nm, and the width varies fro
Theoretical, Experimental and Clinical Studies on Glucose Transport in Peritoneal Dialysis. A Bitter Sweet Symphony.
"Religion och politik är en usel mix"
Sekularistiska normer, antimuslimsk diskurs och religiösa argument i diskussioner om religion och politik på Facebook.
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Abstract in French« Un français transformé en suédois ». Voilà comment Alf Lombard se décrivait lui-même. Il est né à Paris, son père était français et sa mère était suédoise. Il manifestait un intérêt global pour les langues romanes, mais à part le français et l’italien, c’est surtout le roumain qui était son domaine préféré. Les articles sur le français, l’italien et le roumain dans ce volume re
Comparison of guideline- and model-based WWTP design for uncertain influent conditions
In this study, two methods for wastewater treatment plant (WWTP) dimensioning were compared: (1) a traditional guideline-based approach, and (2) a mechanistic model-based approach. The design outputs depended on uncertainties in correlated influent concentrations, which emphasises the importance of uncertainty analysis. The results showed that model-based design could simplify and reduce the time
Why switch? The role of customer variety-seeking and engagement in driving service switching intention
PurposeThis study aims to examine the role of service customers’ variety-seeking and engagement in driving their service switching intention. The authors also explore the moderating role of customer relationship proneness in this association.Design/methodology/approachTo test the hypotheses, the authors deployed a sample of 227 service customers, whose data was analyzed by using partial least squa
Landsbygden och invandrartäta områden i städer – två perspektiv på ojämlikhet
Denna rapport visar att de ökade skillnaderna i levnadsstandard i Sverige har en tydlig geografisk dimension. Framförallt sjunker levnadsstandarden i städernas invandrartäta områden. För Sveriges 5 procent mest invandrartäta områden var den disponibla inkomsten 34 procent lägre än för riket 2017. År 1990 var skillnaden endast 7 procent, vilket innebär ett fall på 27 procentenheter. För Sveriges 5-
A revised compartmental model for biokinetics and dosimetry of 2-[18F]FDG
Background: The aim was to review available biokinetic data, collect own experimental data, and propose an updated compartmental model for 2-[18F]FDG in the frame of the revision of the ICRP report on dose coefficients for radiopharmaceuticals used in diagnostic nuclear medicine. Methods: The compartmental model was developed based on published biokinetic data for 2-[18F]FDG. Additional data on ur
Den postreformatoriska katolicismen i Norden : Mission, konversion och alternativa identitetsdiskurser
This article summarizes and discusses some results of my earlier research focusing on the Catholic mission in Scandinavia and the alternative identity discourses that this missionary activity created. It also discusses Catholic gender discourses and ideals of masculinity. The Nordic countries were subjected to Catholic missionary activity, aimed at bringing the Nordic peoples to convert to the CatThis article summarizes and discusses some results of my earlier research focusing on the Catholic mission in Scandinavia and the alternative identity discourses that this missionary activity created. It also discusses Catholic gender discourses and ideals of masculinity. The Nordic countries were subjected to Catholic missionary activity, aimed at bringing the Nordic peoples to convert to the Cat
HIV incidence and associated risk factors in adolescent girls and young women in South Africa : A population-based cohort study
Background In sub-Saharan Africa, high HIV incidence rates in adolescent girls and young women (AGYW) persist despite extensive HIV prevention efforts. Methods A prospective cohort of 2,710 HIV-negative AGYW (15–24 years) in KwaZulu-Natal, South Africa were interviewed at baseline and followed-up approximately 18 months later (2014–2017). Associations between HIV seroconversion and socio-demograph
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Introduction to A Research Agenda for Sustainable Consumption Governance
Chapter 1, ‘Introduction to A Research Agenda for Sustainable Consumption Governance’ by Oksana Mont sets the scene for the book by discussing sustainable consumption as a grand challenge. It identifies unsustainable consumption and production patterns and levels as one of the main contributing factors to the grand sustainability challenges. Reasons for failure to address unsustainable consumption
Placental molecular mechanisms as pathways linking prenatal exposure to ambient air pollution to preeclampsia and fetal growth
Background: Preeclampsia (PE) is a “multifactorial syndrome” in which ambient air pollution may contribute to the etiology of PE. However, the underlying mechanism of this association is not clearly elucidated. This dissertation aims at understanding the placental molecular mechanism underlying the relationship of prenatal exposure to ambient air pollution with preeclampsia and fetal growth by cha
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Impaired immune function accompanies social evolution in spiders
An efficient immune system is essential to the survival of many animals. Sociality increases risk of pathogen transmission, which should select for enhanced immune function. However, two hypotheses instead predict a weakened immune function: relaxed selection caused by social immunity/protection, and reduced efficacy of selection due to inbreeding, reproductive skew and female bias in social speci
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mu
Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM
The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75–78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on mult