The heart rate during atrial fibrillation (AF) is highly dependent on the conduction properties of the atrioventricular (AV) node, which can be affected using β-blockers or calcium channel blockers, often chosen empirically. Thus, characterization of the AV nodal conduction properties could contribute to personalized treatment of AF. We have created a mathematical network model of the AV node wher

Hjärntumör inklusive glioblastom.Glioblastom är den vanligaste sortens hjärntumör bland vuxna och samtidigt den mest elakartade. Glioblastom drabbar cirka 550 personer årligen i Sverige. När tumören upptäcks är behandlingen först operation för exakt diagnos och med syfte att avlägsna så mycket som det går av tumören, utan att orsaka skada för patienten, annars görs en diagnostisk biopsi. StandardbAbstractBackground: Glioblastoma is the most common malignant brain tumor. Operation with maximal resection, if feasible, otherwise biopsy followed by radiotherapy and chemotherapy with temozolomide is standard therapy. The prognosis remains poor, with median overall survival being 15 months despite therapy. Improved monitoring and treatment response assessment will be important when seeking to im

BACKGROUND: Low birth weight (LBW), advanced glycation end-products (AGE), and ankle-brachial index (ABI) have all been independently associated with risk of cardiovascular disease. Evidence is lacking on the effect of LBW on adult AGE, a marker of glucose metabolism, and ABI, a marker of peripheral atherosclerosis. The objective was to study these associations in a population-based cohort.METHODS

We performed a molecular phylogenetic analysis on the family Euteliidae to clarify deep divergences and elucidate evolutionary relationships at the level of the subfamily, tribe, and genus. Our dataset consists of 6.3 kbp of one mitochondrial and seven nuclear DNA loci and was analysed using model-based phylogenetic methods, that is, maximum likelihood and Bayesian inference. Based on the recovere

Neighborhood support can improve aging in place for older adults, but research on the role of public housing staff in supporting older tenants is lacking. Twenty-nine participants (janitors, n = 11; maintenance staff, n = 18) collected data about critical situations among older tenants residing in apartments in Sweden. Modifying the Critical Incident Technique (CIT) and applying a mixed-methods de

Detta är en studie i det internationella tänkandets subjekt. Människor och stater, om än ofta betraktade som varandras motsatser, delar en sak: de är det internationella tänkandets huvudsakliga subjekt. Avhandlingens argumentet är att orsaken till detta står att finna i det språk genom vilket subjektskap artikuleras, personbegreppets språk, som stipulerar vissa kriterier – i första hand rationalitThis is a study of subjecthood in international thought. Human beings and states, while often held to be opposed to one another, share this: they are international thought’s key subjects. The following chapters attempt to answer the question of why that is. The main argument advanced is that this is because of the particular language in which subjecthood is articulated, the language of personhood,

Studying how small quantum systems, like molecules and clusters, interact with X-rays is crucial to understanding the ultrafast processes that occur in nature on incredibly short timescales, ranging from femtoseconds to picoseconds. X-rays excite small quantum systems to unstable core hole states, leading to a cascade of phenomena, including Auger decay, nuclear rearrangement, and dissociation. Th

The health of coastal marine environments is severely declining with global changes. Proxies, such as those based on microeukaryote communities, can record biodiversity and ecosystem responses. However, conventional studies rely on microscopic observations of limited taxonomic range and size fraction, missing putatively ecologically informative community components. Here, we tested molecular tools

Prognostic tools are an essential component of the clinical management of patients with renal cell carcinoma (RCC). Although tumour stage and grade can provide important information, they fail to consider patient- and tumour-specific biology. In this study, we set out to find a novel molecular marker of RCC by using hepatocyte nuclear factor 4A (HNF4A), a transcription factor implicated in RCC pro

Renal cell carcinomas (RCCs) are a group of tumours that arise from the nephron within the kidney. They are characterised by an indolent growth pattern and do not display overt clinical symptoms in patients with early to locally advanced tumours. Furthermore, the global average age of a RCC patient at diagnosis is 75 and they usually present with co-morbidities that may render invasive surgical/bi

Sedan 2014 har polismyndigheten arbetat med att kartlägga diverse områden och hur de påverkas av den lokala brottsligheten. De områden som är mest drabbade kallar de för utsatta områden.Since 2014, the police authority has worked to map various areas and how they are affected by local crime. The areas that are most affected are called vulnerable areas.

Ungefär hälften av alla cancerpatienter genomgår strålbehandling, antingen som en enskild behandling eller i kombination med kirurgi och/eller medicinsk behandling. Vid strålbehandling används högenergetisk joniserande strålning för att bekämpa cancerceller. Strålningen orsakar skador på tumörcellernas DNA, men kan även skada friska celler. För att uppnå bästa möjliga behandlingseffekt med minsta FLASH radiotherapy (FLASH-RT) is a promising new approach to radiotherapy that has the potential to transform the field. By administering radiation at ultra-high dose rates (UHDR) on a millisecond timescale, FLASH-RT may increase normal tissue tolerance compared to conventional radiotherapy while maintaining the anti-tumoral effect. However, the short treatment times present unique physical and te

The subcellular localization of proteins is closely related to their functions. In this work, we propose a novel approach based on localization motifs to improve the accuracy of predicting subcellular localization of Gram-positive bacterial proteins. Our approach performed well on a five-fold cross validation with an overall success rate of 89.5%. Besides, the overall success rate of an independen

Motivation: Turns are a critical element of the structure of a protein; turns play a crucial role in loops, folds, and interactions. Current prediction methods are well developed for the prediction of individual turn types, including α-turn, β-turn, and γ-turn, etc. However, for further protein structure and function prediction it is necessary to develop a uniform model that can accurately predict

Motivation: The precise prediction of protein domains, which are the structural, functional and evolutionary units of proteins, has been a research focus in recent years. Although many methods have been presented for predicting protein domains and boundaries, the accuracy of predictions could be improved. Results: In this study we present a novel approach, DomHR, which is an accurate predictor of

A novel metabolomic method based on gas chromatography-mass spectrometry was applied to investigate serum metabolites in response to dietary Gln supplementation in piglets. Sixteen, 21-d-old pigs were weaned and assigned randomly to 2 isonitrogenous diets: 1) Gln diet, which contained 1% L-Gln (as-fed basis), and 2) control diet, which contained LAla to make this diet isonitrogenous with the Gln d

Recension av Lutz Gschwinds avhandling "Migrationand social protection inEuropean welfare states:cui bono?" från 2021.

The feasibility of different options to reduce the risks of climate change has engaged scholars for decades. Yet there is no agreement on how to define and assess feasibility. We define feasible as “do-able under realistic assumptions.” A sound feasibility assessment is based on causal reasoning; enables comparison of feasibility across climate options, contexts, and implementation levels; and ref