Popular Abstract in Swedish Parkinsons sjukdom (PS) karaktäriseras av långsam celldöd i hjärnan och gradvis uppträder minskad rörlighet och muskelstelhet som mest framträdande symptom. PS drabbar ungefär 0.1% av befolkningen, och inträder oftast i femtio- till sextioårsåldern. Varför sjukdomen uppkommer är till stor del okänt, men man vet att de dopamin producerande cellerna i mitthjärnan (särskilParkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. Importantly, the neuropathology of PD is dominated by a marked loss of dopaminergic neurons located in the substantia nigra.

Monitoring of events in the power system provides a great deal of insight into the behavior of the system. Events with impact on the entire power system typically occur in or near the transmission network and are therefore best monitored at transmission system substations. This puts great demands on the equipment and in general restricts the use of the data since it becomes property of the transmi

A new predictive formula for the total longshore sediment transport (LST) rate was developed from principles of sediment transport physics assuming that breaking waves mobilize the sediment, which is subsequently moved by a mean current. Six high-quality data sets on hydrodynamics and sediment transport collected during both field and laboratory conditions were employed to evaluate the predictive

Expression of the human cysteine proteinase inhibitor, cystatin C (CysC) in the cytoplasm of Escherichia coli was studied using a cDNA fragment encoding the cysteine proteinase inhibitor controlled by the phage λ pImage /cI857 system. The yield of CysC was low, probably due to proteolytic degradation. By fusing the cysC cDNA to a DNA fragment encoding the signal peptide of the E. coli outer membra

PURPOSE: The reduced size of abdominal aortic aneurysms (AAAs) after endovascular repair suggests lowered intraaneurysmal pressure. In the presence of endoleaks, the size is not decreased. Although postoperative intraaneurysmal pressure is difficult to record, the pulsatile wall motion (PWM) of aneurysms can be measured noninvasively. The aim of this study was to assess the PWM of AAAs before and

Abstract is not available

Several studies have presented data on the efficacy and tolerability of trastuzumab within clinical trials. As a minority of patients is included in these trials, we undertook this retrospective study to describe trastuzumab therapy in clinical routine and its tolerability. We reviewed the medical records of the first 48 patients in Sweden who received treatment with trastuzumab on a named patient

The unstable neutron-deficient Sn-108 isotope has been studied in inverse kinematics by intermediate-energy Coulomb excitation using the RISING/FRS experimental setup at GSI. This is the highest Z nucleus studied so far with this method. Its reduced transition probability B (E2;0(g.s.)(+)-> 2(1)(+)) has been measured for the first time. The extracted B(E2) value of 0.230(57)e(2) b(2) has been dete

Inhaled corticosteroid (ICS) therapy such as fluticasone propionate (FP) is effective in moderate-to-severe asthma, but for patients on ICS who still experience symptoms, treatment guidelines recommend either increasing the dose of ICS or adding a long-acting beta2-agonist such as salmeterol or formoterol. Several studies have now shown that adding salmeterol provides greater clinical benefit than

The introduction of nasal glucocorticosteroids, 30 years ago, has been the most important therapeutic progress in rhinitis management since the introduction of the first generation of antihistamines. Our knowledge of the mode of action of glucocorticosteroids in the nose has improved as the airway mucous membrane of the nose is easily accessible for investigation. However, the exact mechanism behi

Various examinations of sealant joints show that there are many problems with leakage, even in fairly new buildings. Two main reasons have been that the sealant properties are overrated and that the joint design or workmanship is poor due to lack of knowledge about the basic requirements and the material properties. The failure mechanism of an elastic sealant is described. This serves as a basis