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On the interaction between beta 2-microglobulin and group A streptococci

beta 2-microglobulin (beta 2m) was found to interact with many group A streptococcal strains. The interaction appeared to require multipoint attachment, since monomeric beta 2m in solution showed no binding, whereas both beta 2m monomers bound to liposomes, and beta 2m in aggregates showed affinity for the bacteria. Aggregated HLA antigens (-A, -B and -C) and aggregated beta 2m exhibited the same

Association studies of BMI and type 2 diabetes in the neuropeptide y pathway - A possible role for NPY2R as a candidate gene for type 2 diabetes in men

The neuropeptide Y (NPY) family of peptides and receptors regulate food intake. Inherited variation in this pathway could influence susceptibility to obesity and its complications, including type 2 diabetes. We genotyped a set of 71 single nucleotide polymorphisms (SNPs) that capture the most common variation in NPY, PPY, PYY, NPY1R, NPY2R, and NPY5R in 2,800 individuals of recent European ancestr

Scatter and attenuation correction in SPECT using density maps and Monte Carlo simulated scatter functions

A new scatter and attenuation correction method is presented in which Monte Carlo simulated scatter line-spread functions for different depth and lateral positions are used. A reconstructed emission image is used as an estimate of the source distribution in order to calculate the scatter contribution in the projection data. The scatter contribution is then subtracted from the original projection p

CSF studies in violent offenders. I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy

Low serotonin activity in man has been related to impulsive, self-destructive violence but not to instrumental aggression aimed at dominance. A relationship has also been suggested between aggression and high catecholaminergic activity. Several studies have reported signs of aberrant dopaminergic function in attention deficit hyperactivity disorder, autism, and schizophrenia. In 22 violent offende

Airborne cognitive systems in search of an appropriate context: Studies of the introduction of new technology in aviation using a cognitive systems engineering approach

Popular Abstract in Swedish Sammanfattning Teknik är alltid skapad för en förväntad brukare i ett antaget sammanhang. Inom kommersiell luftfart är dessa antaganden när det gäller design tydliga. Såväl besättning som utrustning är certifierad för en viss typ av operationer i enlighet med flygplanets drifthandbok. Trots denna genomtänkta definition av användare i sitt sammanhang händer det ändå attAbstract Technology is always designed for an assumed user in an assumed context. In commercial aviation, these design assumptions are clearly spelt out in that both crew and equipment are certificated for a specific operation as stated in the aircraft flight manual. Despite this well defined user context, the designed-for and the real contexts often differ enough so that adaptations of working p

The morphology of the chemosensory aesthetasc-like setae used during settlement of cypris larvae in the parasitic barnacle Sacculina carcini (Cirripedia : Rhizocephala)

Rhizocephalans of the suborder Kentrogonida are parasitic barnacles whose female cypris larvae must locate a suitable host organism (a decapod crustacean), while the male cypris larvae must find a host containing a virgin female. Some of the sensory structures assumed to be involved in this behaviour are the aesthetasc-like setae found on antennules of the cyprids, of which the females possess one

Optimal control for systems with varying sampling rate

The paper addresses the aspects of control of real time systems with varying sampling rate. An example is given in which a stable continuous system is sampled at two different sampling rates. Two controllers are designed to minimize the same continuous quadratic loss function with the same weights. It is shown that although the design leads to stable controlled closed loop systems, for both discre

Neurogenesis in stroke and epilepsy

Ischemic and epileptic insults promote neurogenesis from neural stem cells located in the dentate subgranular zone and in the subventricular zone lining the lateral ventricles. These findings raise the possibility that the adult brain tries to use its own stem cells to repair itself. New neurons generated by ischemic insults have now been shown to migrate from the subventricular zone and posterior

The cultured neuroretina: development, survival and transplantation

Popular Abstract in Swedish Näthinnan är den del av ögat som tar emot ljussignaler och omvandlar dem till elektriska signaler. Dessa signaler förs sedan vidare via synnerven till hjärnan för att man skall kunna erhålla en synupplevelse. Näthinnan består av flera celltyper och en av dessa är fotoreceptorcellen, som omvandlar ljus till elektriska signaler, den s.k. fototransduktionen. Den del av fotIn the cultured immature rat full-thickness neuroretina, massive apoptosis appears in the GCL within hours after explantation, but in the ONL cell death is low. Microglia cells become activated when the retina is kept in culture and are found in the GCL within 24 hours of culture. Embryonic porcine retina kept in culture can survive and develop according to its intrinsic timetable for at least si

Temperature-dependent changes in the soil bacterial community in limed and unlimed soil

A humus soil with a pH(H2O) of 4.9 was limed to a pH of 7.5 and was incubated together with samples from unlimed and field limed (pH 6.1) soils at 5, 20 and 30degreesC for up to 80 days. The changes in the phospholipid fatty acid (PLFA) pattern were most rapid for the bacterial community of the soil incubated at 30degreesC, while no changes were found in the soil incubated at 5degreesC. The respon

Selected research studies from Scandinavia : dedicated to professor Göran Fagerlund on his 60th anniversary November 11, 1997

The book contains selected articles from research in different areas produced by scientists in Scandinavia. However, many of the articles are based upon professor Göran Fagerlund's original ideas. Titles: 1.Cementitious injection grouts - penetration ability (Alemo, J. & Hansson, P.). 2.A disadvantage of high performance concrete and a simple way to avoid it (Alexanderson, J). 3. Early age t

Critical evaluation of factors affecting chloride initiated reinforcement corrosion in concrete

This licentiate study has been completed as a part of a larger experimental program "Durability of Reinforced Concrete Structures in Marine Environment" carried out in Sweden and Denmark. The aim of this work has been to identify and critically evaluate some major parameters influencing the onset of active reinforcement corrosion in concrete in marine environment. Since the topic is naturally very

Det trovärdiga vittnet

Artikeln diskuterar frågan om vittnets och vittnetsmålets trovärdighet utifrån ett antal nedslag i idéhistorien. Den berör vittnetsmålets epistemologiska, psykologiska och politiska problematik och utnyttjar som röd tråd linjen från Sokrates/Platon och Jesus/lärjungarna.

Concrete slab on the ground and moisture control : verification of some methods to improve the moisture conditions in the foundation

This work deals with different types of repair methods for concrete slab on the ground damaged by moisture. Many of the available methods involve some kind of mechanical ventilation of the foundation. The basic principle for all these systems is the same. By establishing air movement through an air-permeable layer below or above the concrete slab, the flowing air can absorb moisture from surroundi