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Effect of glibenclamide on membrane response to metabolic inhibition in smooth muscle of rat portal vein

Vascular smooth muscle tone is dependent on oxidative metabolism, a phenomenon of potential importance for the metabolic regulation of blood flow to tissues. The response of the rat portal vein to inhibition of cell respiration by cyanide (0.1-1 mM) is a reduction of its spontaneous myogenic activity. The trains of action potentials triggering phasic contractions are reduced in duration, while the

Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+

The block of rabbit skeletal ryanodine receptors (RyR1) and dog heart RyR2 by cytosolic [Mg2+], and its reversal by agonists Ca2+, ATP and caffeine was studied in planar bilayers. Mg2+ effects were tested at submaximal activating [Ca2+] (5 microM). Approximately one third of the RyR1s had low open probability ("LA channels") in the absence of Mg2+. All other RyR1s displayed higher activity ("HA ch

An integrated analysis of ergonomics and time consumption in Swedish "craft-type' car disassembly

Car disassembly is at the edge of extensive rationalisations due to increased legislative demands for recycling. This study focused on (1) assessing Current mechanical exposures (physical work loads) for comparison with future rationalised systems, with particular emphasis on time aspects, (2) analysing disassembly work in terms of time consumption and exposures in constituent tasks as defined by

Skapa plats i landskapet : tidig- och mellanneolitiska samhällen utmed två västskånska dalgångar

Popular Abstract in SwedishDenna arkeologiska studie syftar till att förstå de neolitiska samhällenas framväxt, organisation och förändring kring de västskånska ådalgångarna vid Saxån-Välabäcken och Lödde å-Kävlingeån. Arkeologiska undersökningar och fornminnesinventeringen har visat att området hyser omfattande lämningar av neolitiska bebyggelsekomplex — i form av bosättningar, gravfält, megalitgThis dissertation deals with Early and Middle Neolithic societies in a valley landscape in western Scania, in the southern part of Sweden. Several archaeological excavations conducted by the National Heritage Board have revealed a great number of Neolithic remains in this region. The sites constitute a substantial continuous sequence from the earliest to the latest phase of the Funnel Beaker Cultu

Serum concentrations of cartilage oligomeric matrix protein, fibrinogen and hyaluronan distinguish inflammation and cartilage destruction in experimental arthritis in rats.

OBJECTIVES:We investigated if changes in serum/plasma fibrinogen (FIB), hyaluronan (HA) and cartilage oligomeric matrix protein (COMP) levels can be used to differentiate between inflammation and cartilage involvement during arthritis. METHODS:Collagen-induced arthritis (CIA), oil-induced arthritis (OIA) and for comparison, experimental autoimmune encephalitis (EAE) induced in DA rats were investi

Review of Oloph Bexell, Präster i S:t Sigfrids stift 3. Minnesteckningar till prästmötet i Växjö stift 2002. Lund 2002

Bexell tecknar minnet av 78 präster. Omfattande forskningsinsatser ligger bakom den 29 sidor långa biografin över domprosten Gustaf Adolf Danell, som utreder frågan varför Danell, som uppfördes på åtta biskopsförslag, aldrig utnämndes. Ärkebiskop Brilioth sökte redan 1956 aktivt avvärja utnämning av Danell, som kritiserat biskoparnas ämbetsförvaltning och saknade kompromissförmåga. Bexell förenar

Morphology, structure, and electronic properties of Ce@C-82 films on Ag : Si(111)-(root 3x root 3)R30 degrees

The adsorption behaviour and electronic properties of Ce@C-82 molecules on the Ag: Si(l I I)-(root3 x root3)R30degrees surface have been studied using scanning tunnelling microscopy and photoelectron spectroscopy. Submonolayer coverages and multilayer films of Ce@C-82 comprise highly ordered molecular domains which have a single, well-defined orientation with respect to the underlying substrate cr

Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase.

The kinetics of furfural inhibition of the enzymes alcohol dehydrogenase (ADH; EC 1.1.1.1), aldehyde dehydrogenase (AlDH; EC 1.2.1.5) and the pyruvate dehydrogenase (PDH) complex were studied in vitro. At a concentration of less than 2 mM furfural was found to decrease the activity of both PDH and AlDH by more than 90%, whereas the ADH activity decreased by less than 20% at the same concentration.

Hepatic lipase activity increases after liver denervation in the rat

We have investigated the effects of hilar denervation of rat liver upon the activity of hepatic lipase determined in tissue extracts. Denervated animals had an enzyme activity of 7.89 +/- 0.37 mU/mg protein, compared to 6.45 +/- 0.43 in sham-operated controls (mean +/- S.E.; P less than 0.05). We conclude that hepatic innervation may contribute to the regulation of hepatic lipase activity.

Performance of health-status scales when used selectively or within multi-scale questionnaire

BACKGROUND: Little work has been done to investigate the suggestion that the use of selected scales from a multi-scale health-status questionnaire would compromise reliability and validity. The aim of this study was to compare the performance of three scales selected from the SF-36 generic health questionnaire when administered in isolation or within the entire SF-36 to patients with musculoskelet

On the systematic measurement errors of correlative mobile radio channel sounders

We show that measurements of time-varying mobile radio channels obtained with uncalibrated correlative channel sounders are affected by four different types of systematic errors (commutation, pulse-compression, aliasing, and misinterpretation error). We analyze these errors and provide upper error bounds that are formulated in terms of channel and sounder parameters. Based on these error bounds, w

Mesenchymal Stem Cells in Tumor Growth Inhibition and Cartilage Differentiation

The work presented in this thesis has been focused on mesenchymal stem cells (MSCs). In the two first studies, the effects of MSCs on tumor growth and development in vitro and in vivo was investigated. In the third study the expression of the integrins alpha10beta1 and alpha11beta1 on MSCs was characterized and the involvement of these two integrins in cartilage development was investigated in vit

Essential fatty acids and phosphorus in seston from lakes with contrasting terrestrial dissolved organic carbon content

1. It is often assumed that lakes highly influenced by terrestrial organic matter (TOM) have low zooplankton food quality because of elemental and/or biochemical deficiencies of the major particulate organic carbon pools. We used the biochemical [polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA) - 20:5 omega 3] and elemental (C : P ratio) composition of particulate matter (PM) as