Background: Metastatic breast cancer (MBC) is a challenging disease, and despite new therapies, prognosis is still poor for a majority of patients. There is a clinical need for improved prognostication where immuno-oncology markers can provide important information. The aim of this study was to evaluate serum immuno-oncology markers in MBC patients and their respective relevance for prediction of

Background: Functionally disruptive variants in the glucokinase gene (GCK) cause a form of mild non-progressive hyperglycemia, which does not require pharmacological treatment. A substantial proportion of patients with type 2 diabetes (T2D) carry GCK variants. We aimed to investigate whether carriers of rare GCK variants diagnosed with T2D have a glycemic phenotype and treatment response consisten

Surveys of urban history from ancient times to the present reveal a continuum of collective responses to pandemics ranging from quarantine facilities and monitoring the spread of disease to building new wastewater networks. The contemporary COVID-19 pandemic includes new digital tools and techniques that supplement (and sometimes replace) the existing analogue responses, while raising new ethical

This study investigates the impact in terms of radiation dose when performing simultaneous digital breast tomosynthesis(DBT) and mechanical imaging (MI) – DBTMI. DBTMI has demonstrated the potential to increase specificity of cancerdetection, and reduce unnecessary biopsies, as compared to digital mammography (DM) screening. The presence of theMI sensor during simultaneous image acquisition may in

Uppgifter om de tidigaste hedersdoktoraten respektive första kvinnliga hedersdoktorerna vid de olika fakulteterna inom Lunds universitet samt fördjupningar kring några specifika historiska fall av tilltänkta eller utdelade hedersdoktorat.

This study investigates how art museums of Copenhagen currently (2022) are rediscovering the “forgotten” female artists associated with the Danish modernism. Through discourses in exhibition labels, the methods for curating rediscovering narratives are examined. Specifically, it studies the textual subject positioning of artists in relation to their gender, to the art they create and to the social

Objectives: Artificial intelligence (AI) is increasingly tested and integrated into breast cancer screening. Still, there are unresolved issues regarding its possible ethical, social and legal impacts. Furthermore, the perspectives of different actors are lacking. This study investigates the views of breast radiologists on AI-supported mammography screening, with a focus on attitudes, perceived be

The brain is the key organ that orchestrates the stress response which translates to the retina. The retina is an extension of the brain and retinal symptoms in subjects with neurodegenerative diseases substantiated the eye as a window to the brain. The retina is used in this study to determine whether chronic stress reflects neurodegenerative signs indicative of neurodegenerative conditions. A 3-

PURPOSE: Galectin-3, a β-galactoside-binding lectin, plays a key role in several cellular pathways involved in chronic inflammation, heart disease and cancer. GB1211 is an orally bioavailable galectin-3 inhibitor, developed to be systemically active. We report safety and pharmacokinetics (PK) of GB1211 in healthy participants.METHODS: This phase 1, double-blind, placebo-controlled, first-in-human

The main goal of this thesis is to find an effective way to fuzz trusted applications (TAs) with source code residing in trusted execution environment (TEE). While fuzzing TAs has been previously done, no work has been found to utilize the source code of TAs to improve the fuzzing. Utilizing the source code in fuzzing can lead to an increase in code coverage compared to black-box fuzzing, and ther

Asthma is a chronic inflammatory lung disease affecting over 300 million individuals worldwide. Both respiratory viral infections and aeroallergens have been identified as important risk factors for asthma. Rhinovirus (RV) infection has been recognized as a major cause of asthma exacerbations, and current research indicates that RV and allergens may have a synergistic effect, resulting in a higher

This study explores how a contemporary systemic shift regarding secrecy and intelligence is affecting the strategic performance of states engaged in overt or covert intervention. These changes are conceptualized by researchers as “implausible deniability”, “delayed disclosure” and “the democratization of intelligence” and their significance are applied to limited-war theory with a theoretical focu

In state formation research, princely houses have been a blind spot. The development of states has been discussed from many perspectives, like interstate competition, internal social conflicts, fiscal-military developments, etc., but at the centre of most European states, there was a princely house. These ruling houses have been overlooked in studies about state formation. What’s more, when discus

Objective Blood cell populations, including red blood cells (RBC) unique to the extremely preterm (EPT) infant, are potentially lost due to frequent clinical blood sampling during neonatal intensive care. Currently, neonatal RBC population heterogeneity is not described by measurement of total haemoglobin or haematocrit. We therefore aimed to describe a subpopulation of large RBCs with hyper high

Hydrothermal explosions are significant potential hazards in Yellowstone National Park, Wyoming, USA. The northern Yellowstone Lake area hosts the three largest hydrothermal explosion craters known on Earth empowered by the highest heat flow values in Yellowstone and active seismicity and deformation. Geological and geochemical studies of eighteen sublacustrine cores provide the first detailed syn

Miniessä om Johan Jönsons diktsamling ProponeisiS

Transportation noise is a growing public health concern worldwide and epidemiological evidence has linked road traffic noise with mortality. However, incongruent effect estimates have been reported between incidence and mortality studies. Therefore, the present study aimed to investigate whether long-term exposure to residential road traffic noise at the most and least exposed façades was associat