Biomolecules preserved in deep time have potential to shed light on major evolutionary questions, driving the search for new and more rigorous methods to detect them. Despite the increasing body of evidence from a wide variety of new, high resolution/high sensitivity analytical techniques, this research is commonly met with skepticism, as the long standing dogma persists that such preservation in

It has previously been shown that the incretin effect accounts for ≈50% of the insulin response to oral glucose in normal mice. Now, I have proceeded and studied the contribution of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) to the insulin response to oral glucose in female mice by using receptor antagonists. A specific GIP receptor antagonist (mGIP(3-30

Aim To examine the associations between individual- and disease-related factors and the odds of reaching a clinically relevant pain reduction in people with knee and/or hip osteoarthritis (OA) who underwent a first-line self-management program. Materials and methods An observational registry-based study including people with knee (n = 18,871) and hip (n = 7,767) OA who participated in a self-manag

Different tau biomarkers become abnormal at different stages of Alzheimer's disease, with CSF phospho-tau typically becoming elevated at subthreshold levels of tau-PET binding. To capitalize on the temporal order of tau biomarker-abnormality and capture the earliest changes of tau accumulation, we implemented an observational study design to examine longitudinal changes in Tau-PET, cortical thickn

Although combined heat and power (CHP) production in Sweden is already largely decarbonised, this technology has further potential to alleviate pressing environmental concerns. Today, biobased CHP plants connected to district heating (DH) grids dominate the Swedish residential heating sector. The societal context in which CHP plants operate is, however, subject to continuous change. New aims and r

George Eliot predicates the two principal characters of her second novel, The Mill on the Floss (1860), not on fixed traits but on gendered differences in styles of body movement. This chapter approaches the interplay of medicine and mobility through the lens of the feminist phenomenology of perception, situating Eliot’s configuration of the gendered scripts of posture in the proto-orthopaedic dis

Under snart tre decennier har omfattande insatser genomförts för att få mäns våld mot kvinnor att upphöra, utan synbar effekt. Våldet tenderar snarare att öka. Varför tycks mäns våld mot kvinnor vara ett olösligt samhällsproblem? I denna rapport undersöker vi hur mäns våld mot kvinnor har hanterats i svensk politik de senaste 25 åren. Med utgångspunkt i offentligt tryck granskar vi den politiska r

Protein intake is higher in formula-fed than in breast-fed infants during infancy, which may lead to an increased risk of being overweight. Applying alpha-lactalbumin (α-lac)-enriched whey or casein glycomacropeptide (CGMP)-reduced whey to infant formula may enable further reduction of formula protein by improving the amino acid profile. Growth, nutrient intake, and protein metabolites were evalua

Developments in sequencing technologies and the sequencing of an ever-increasing number of genomes have revolutionised studies of biodiversity and organismal evolution. This accumulation of data has been paralleled by the creation of numerous public biological databases through which the scientific community can mine the sequences and annotations of genomes, transcriptomes, and proteomes of multip

Aims. Dust plays a crucial role in the evolution of protoplanetary disks. We study the dynamics and growth of initially submicron dust particles in self-gravitating young protoplanetary disks with various strengths of turbulent viscosity. We aim to understand the physical conditions that determine the formation and spatial distribution of pebbles when both disk self-gravity and turbulent viscosity

Calcareous nannofossils evolved in the global ocean from the Carnian (early Late Triassic) and have contributed to the accumulation of biogenic calcium carbonate in marine sediments since then. Bio-diversification and bio-productivity became more significant in the Rhaetian (Late Triassic), representing an important period to understand the dynamics of calcareous nannofossil evolution. The calcare