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Circulating endothelial progenitor cells in periodontitis

Background: Several biologically plausible mechanisms have been proposed to mediate the association between periodontitis and atherosclerotic vascular disease (AVD), including adverse effects on vascular endothelial function. Circulating endothelial progenitor cells (cEPCs) are known to contribute to vascular repair, but limited data are available regarding the relationship between cEPC levels and

Long‐term use of aversive drugs in outpatient alcoholism treatment

In a 2‐year outpatient treatment programme for alcoholics, 90% of the patients used aversive drugs during some part of the treatment period. Long‐term use was significantly related to a favourable drinking outcome during 2 years subsequent to treatment compared with short‐term use. Long‐term and short‐term users did not differ in background data. Continued use of aversive drugs after the first 6 m

Inhibition of platelet aggregation by granulocytes stimulated during experimental trauma

The effect of granulocytes, stimulated in vivo by standardized soft tissue trauma, on the aggregation of autologous platelets in vitro, was studied in the pig. Platelet aggregation induced by ADP and arachidonic acid was inhibited when platelets harvested before trauma were incubated with granulocytes obtained 5 min after trauma. The granulocytes were separated from the platelets during the incuba

Bargaining for Trade: When Exporting Becomes Detrimental for Female Wages

In this paper we study the link between globalization of firms and gender inequality. Specifically, we examine how the need for interpersonal contacts in trade and gender-specific differences in negotiations are related to the gender wage gap. Our key finding is that export of goods that are intensive in interpersonal contacts widens the gender wage gap. The effect is robust across various specifi

Collegiality and efficiency in bureaucracy

This article addresses the relation between the design of regulatory agencies and efficiency, arguing that authority concentrated to a single individual outperforms more collegial decision-making when the regulated firms’ interests are aligned. The tentative explanation is that concentrated leadership reduces the risk for capture. This argument is developed from an empirical case on the markets fo

Fluid sloshing hydrodynamics in a cryogenic fuel storage tank under different order natural frequencies

Liquid hydrogen is a promising energy carrier due to its excellent performance. However, liquid hydrogen sloshing usually causes serious issues on its safety production, storage, transportation, application and management. To study fluid sloshing in cryogenic storage tanks, a numerical calculation model is developed with considerations of the environmental heat leakage and phase change occurring a

Peer gender and mental health

Adolescent mental health is key for later well-being. Yet, causal evidence on environmental drivers of adolescent mental health is scant. We study how an important classroom feature—the gender composition in compulsory-school—affects mental health. We use Swedish administrative data (N = 576,285) to link variation in gender composition across classrooms within cohorts to mental health. We find tha

Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort

Food additives (e.g. artificial sweeteners, emulsifiers, dyes, etc.) are ingested by billions of individuals daily. Some concerning results, mainly derived from animal and/or cell-based experimental studies, have recently emerged suggesting potential detrimental effects of several widely consumed additives. Profiles of additive exposure as well as the potential long-term impact of multiple exposur

Prospective association between organic food consumption and the risk of type 2 diabetes : findings from the NutriNet-Santé cohort study

BACKGROUND: Organic food (OF) consumption has substantially increased in high income countries, mostly driven by environmental concerns and health beliefs. Lower exposure to synthetic pesticides has been systematically documented among consumers of organic products compared to non-consumers. While experimental studies suggest that pesticides currently used in food production may be associated with

Energy transfer in multi-funnel systems quantitatively assessed by two-dimensional polarization imaging and single funnel approximation : From single molecules to ensembles

Two-dimensional polarization imaging (2D POLIM) is an experimental method where correlations between fluorescence excitation- and fluorescence emission-polarization properties are measured. One way to analyze 2D POLIM data is to apply a so-called single funnel approximation (SFA). The SFA allows for quantitative assessment of energy transfer between chromophores with identical spectra [homo-FRET (

Measuring Oral Direct Inhibitors (ODIs) of thrombin and factor Xa : A recommendation from the Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis

Oral direct inhibitors (ODIs) of thrombin and factor Xa are now approved as anticoagulant drugs. The first two drugs to complete phase III clinical trials for thromboprophylaxis in orthopaedic surgery and treatment of patients with atrial fibrillation or venous thromboembolism were dabigatran and rivaroxaban. These small molecules are given at fixed dose with no requirement for monitoring as pharm

More efficient reversal of dabigatran inhibition of coagulation by activated prothrombin complex concentrate or recombinant factor VIIa than by four-factor prothrombin complex concentrate

The number of patients on antithrombotic treatment due to atrial fibrillation and venous thromboembolism is increasing fast due to an aging population. A growing proportion will be treated with novel oral anticoagulants, the first in clinical use was the direct oral thrombin inhibitor dabigatran (Pradaxa®). A small percentage of the patients on dabigatran will experience serious bleeding or be in