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The aggregation and accumulation of pathologic forms of the microtubule-associated tau protein into fibrils, eventually forming characteristic tangle pathology, hallmarks the majority of all dementia disorders which constitute the most prevalent family of neurodegenerative disorders. These so-called tauopathies are difficult to identify and diagnose, especially at early disease stages. The relativ
This article examines changes in the repertoire of contention in Sweden during the crucial years of democratisation. Based on a dataset of applications to organise public marches in Stockholm 1887-1920, the study looks at the overall trends in the political use of demonstrations: which organisations applied to stage demonstrations and which organisations obtained permission from the authorities. T
The local average treatment effect (LATE) estimator has enabled a wide range of empirical studies that usenatural experiments to estimate causal effects from observational data. However, this empirical literature has overlooked a crucial assumption regarding the definition of the treatment—thepart of the stable unit treatment value assumption referred to asthe consistency assumption in epidemiolog
Plain Language Summary: What is the study about? Hemophilia A is a genetic bleeding disorder that causes bleeding for long periods because of lower than normal levels of factor VIII (FVIII), a protein that is important for blood clotting. FVIII replacement therapy is the typical approach to manage bleeds, but new and improved therapies are becoming widely available. Prophylaxis with the medication
EVs increase demand for critical raw materials (CRMs). Many of the CRMs are mined in just a handful of countries, raising security concerns among business and policymakers. Lithium is particularly precarious due to its high geographic supply concentration, high demand growth rate and few near term substitutes. This study conducts a bottom-up assessment of European lithium extraction projects. The
We present a Raman study of axially heterostructured InP/InGaP nanowires (NWs) for tandem solar cells. The study is carried out using both microRaman spectroscopy (µ-Raman), and tip enhanced Raman spectroscopy (TERS). The results obtained by both methods are compared. The results obtained with each one is supported by the simulation of the light/NW interaction using finite element methods. This si
Introduction: Most neurodegenerative diseases, including Alzheimer's disease (AD) and multiple sclerosis (MS), feature abnormal tau phosphorylation (p-tau) in the brain. Prior immunostaining studies have shown p-tau accumulation in the AD retina, suggesting it may mirror brain tau pathology. Methods: We used mass spectrometry to quantify p-tau peptides in matched retinal and hippocampal samples fr
This paper demonstrates how nostalgia entices consumers to re-circulate objects rather than discard them. Through multimethod qualitative inquiry into the Danish vintage cycling community, this paper highlights how consumers’ nostalgic attachment to the biographies of old objects propels re-circulation. The analysis builds on three distinct modes of nostalgia: reluctant, progressive, and playful n
To plan for a sustainable transportation network, we need to understand the values connected to existing structures. In the history of car dependency and petroculture, the promise of speed is everywhere. Through a frame analysis focusing on contestation, this paper examines values connected to fossil fuel infrastructure. Specifically, the paper interrogates the plans to construct a highway on the
Autonomous robots must operate reliably and safely under uncertain, dynamic conditions over extended periods. To ensure such operational robustness, it is vital that both developers and operators can clearly and verifiably specify functional requirements and safety constraints throughout the robot software lifecycle. My research targets different layers of robot operational safety: early error det
This paper acknowledges the influence of Dr Rita Fahy’s life’s work on a research project to evaluate fire evacuation guidance from high-rise residential buildings. It compares the application of agent-based simulations with Rita’s publications into pre-evacuation delay times. Her observed bi-modal distribution shape aligns with an approach to modelling pre-evacuation time as a series of component
Sialoblastoma is an exceedingly rare, low-grade malignancy, most frequently arising in the parotid gland. Only four case reports detailing the cytomorphology of this neoplasm exist in the English literature. Here, we describe the cytological features, histopathology, and clinical data of sialoblastomas presented at birth in two additional patients. Both neoplasms were initially examined by fine-ne
Orbit separation dimension , previously introduced as amorphic complexity, is a powerful complexity measure for topological dynamical systems with pure-point spectrum. Here, we develop methods and tools for it that allow a systematic application to translation dynamical systems of tiling spaces that are generated by primitive inflation rules. These systems share many nice properties that permit th
Lattice-based cryptography is in the process of being standardized. Several proposals to deal with side-channel information using lattice reduction exist. However, it has been shown that algorithms based on Bayesian updating are often more favorable in practice. In this work, we define distribution hints; a type of hint that allows modelling probabilistic information. These hints generalize most p
With the advancement in autonomous driving technology, the shape of vehicle seats is expected to change. Against this backdrop, a study is required to verify whether or not the diversely-changing seat arrangements are appropriate from the emotional perspective of the driver. This study set the first-row passenger scat with an adjustable seatback, such as an upright position, a 15-degree rotation,
This paper presents experimental and numerical investigations of liquid droplet/air two-phase flow through face masks. The study aims to provide a deeper understanding of the droplet filtration process, generate experimental data for modeling droplet/air two-phase flow across face masks, and develop and validate numerical models to simulate droplet motion through the mask and downstream. Droplet i
Introduction. Online pharmacies are playing an increasingly important role for both citizens and society. In the digital landscape, both legal and illegal online pharmacies are competing for visibility and customer appeal. This article analyses the layout and characteristics of online pharmacy websites. Method. The article is based on a qualitative study of legal and illegal online pharmacy websit
Accurate imputation is essential for the reliability and success of downstream tasks. Recently, diffusion models have attracted great attention in this field. However, these models neglect the latent distribution in a lower-dimensional space derived from the observed data, which limits the generative capacity of the diffusion model. Additionally, dealing with the original missing data without labe
This article is a collective response to the 2020 iteration of The Manifesto for Teaching Online. Originally published in 2011 as 20 simple but provocative statements, the aim was, and continues to be, to critically challenge the normalization of education as techno-corporate enterprise and the failure to properly account for digital methods in teaching in Higher Education. The 2020 Manifesto cont
