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With population aging, more adults across Europe face competing demands of working for pay and caring for elderly family members. Associated tradeoffs are expected to be negative, gendered, and vary across contexts with different levels of gender equality, public support for eldercare, and work-family balance. Using SHARE data from 2004–20, this study investigates how unpaid caregiving to independ
Cities with limited traditions in cycle planning often look to Northern European cities as role models, adopting their design concepts and infrastructure solutions. However, experience indicates that transferring such designs across different contexts can be challenging. In many cases, cycle paths have been constructed but remain underutilized. This chapter presents the findings of a study examin
Classical graphical modeling of random vectors uses graphs to encode conditional independence. In graphical modeling of multivariate stochastic processes, graphs may encode so-called local independence analogously. If some coordinate processes of the multivariate stochastic process are unobserved, the local independence graph of the observed coordinate processes is a directed mixed graph (DMG). Tw
Co- and post-translational modifications can significantly impact the structure, dynamics, and function of proteins. In this study, we investigate how N-terminal acetylation affects misfolding and self-assembly of the enzyme superoxide dismutase 1 (SOD1), implicated in amyotrophic lateral sclerosis (ALS). Studies of protein inclusions in patient samples and animal models have shown that wild-type
Background: Available fluid biomarkers, neuroimaging techniques, and clinical assessments may enhance prediction of conversion to secondary progressive multiple sclerosis (SPMS). Objectives: : To identify robust real-world predictors of MS progression in the literature. Methods: : A systematic review was conducted in EMBASE. A total of 20,338 MS patients from 64 eligible studies were included. A p
The glioblastoma (GBM) microenvironment undergoes adaptations to support tumor progression, including a dysregulated extracellular matrix, with altered heparan sulfate (HS) proteoglycans. We investigated N-deacetylase/N-sulfotransferase-1 (NDST1) because NDSTs are initial modifying enzymes of HS biosynthesis and have key roles in designing the HS sulfation pattern. This, in turn governs interactio
Our study examined the chemical composition of fluvial and eolian sediments at the Velika Vrbica multisection, located on the bank of the Danube River in eastern Serbia, within the westernmost part of the lower Danube (Dacian) Basin. The multisection comprises two discrete sections: an older 2.7 m thick fluvial section, and a younger 11.2 m thick loess-paleosol sequence (LPS). These are exposed al
In the 1970s, researchers and theoreticians of states of consciousnessjointly discussed hypnosis and psychedelic alterations of consciousness,but recent research has mostly kept these topics apart. This paperdiscusses the similarities and differences of hypnosis and psychedelicalterations of consciousness, stressing that states of consciousnessshould not be defined by their preceding contexts. Pre
Cutting edge preparation is crucial in metal cutting as the edge geometry significantly influences both the material removal process and tool life. However, an analytical model that can physically describe the cutting edge preparation process has not yet been established. Taking the wet abrasive jet machining (WAJM) method as an example, the following questions always remain: Why does WAJM always
Lysine acetylation, once viewed primarily as a histone mark, is now recognized as a widespread regulator of protein function. Recent breakthroughs in chemical labeling, isotopic tagging workflows, and data-independent acquisition mass spectrometry enable precise, site-specific quantification of acetylation stoichiometry. This quantitative “acetylomics” approach reveals a “rheostat” model, where mo
Multi-electron donation remains a challenge for CO2 photocatalytic conversion to multi-electron products due to the efficient Auger recombination or annihilation at multiple excitation conditions for conventional molecules or semiconductor photocatalysts. In this paper, we demonstrated possible multi-electron donation within a quantum dot (QD)/metal complex hybrid photocatalyst system when multipl
A causal inference framework was developed to investigate crop responses to agricultural drought by integrating meteorological data, Sentinel-2-derived data, and soil property maps. To account for crop rotation, soil, and topographical variables, propensity score matching was employed to estimate drought-induced yield losses at the field level for selected periods. The Plant Phenology Index (PPI)
Peatlands are vital ecosystems that regulate global carbon storage and hydrology, driven by waterlogged conditions that foster organic matter accumulation. However, disentangling the interactions between climate, hydrology, and tree growth in peatlands remains challenging. To investigate these relationships, we developed a 117-year ring width (RW) chronology (1902–2019) and complementary intra-ann
An integrated framework is introduced and applied to assess the health impact of airborne pollution with greater physiological relevance, moving beyond conventional exposure metrics. Measured particle number size distribution data was integrated with a regional respiratory tract deposition fractions to estimate total and alveolar deposited particle surface area concentrations. Land use regression
Purpose:This paper aims to contribute to the understanding of the recirculation of products by empirically exploring, conceptualising and explaining how second-hand goods are made in practices and processes of valuation.Design/methodology/approach: The paper takes a practice theory approach to valuation and draws on an ethnographic study of ReTuna, a second-hand shopping mall, to explore the valua
