We consider the problem of locating multiple interacting quantitative trait loci (QTL) influencing traits measured in counts. In many applications the distribution of the count variable has a spike at zero. Zero-inflated generalized Poisson regression (ZIGPR) allows for an additional probability mass at zero and hence an improvement in the detection of significant loci. Classical model selection c

The classical model selection criteria, such as the Bayesian Information Criterion (BIC) or Akaike information criterion (AIC), have a strong tendency to overestimate the number of regressors when the search is performed over a large number of potential explanatory variables. To handle the problem of the overestimation, several modifications of the BIC have been proposed. These versions rely on su

High-spin states in 86Zr up to 30+ and 27- were observed via the 58Ni(32S,4p) reaction at 135 MeV beam energy using the combined GAMMASPHERE and MICROBALL systems. Calculations performed with the configuration-dependent shell-correction approach show that these states are built from six g9/2 neutrons and at most four protons excited from the p1/2,p3/2,f5/2 subshells to the g9/2 subshell at small d

Background: Apnea of prematurity is a common problem in preterm infants that may have significant consequences on their development. Methylxanthines (aminophylline, theophylline, and caffeine) are effective in the treatment of apnea of prematurity. Doxapram is used as a respiratory stimulant in cases refractory to the methylxanthine treatment. Objectives: To evaluate the benefits and harms of doxa

Interacting systems of events may exhibit cascading behavior where events tend to be temporally clustered. While the cascades themselves may be obvious from the data, it is important to understand which states of the system trigger them. For this purpose, we propose a modeling framework based on continuous-time Bayesian networks (CTBNs) to analyze cascading behavior in complex systems. This framew

Neurons with internal memory have been proposed for biological and bio-inspired neural networks, adding important functionality. We introduce an internal time-limited charge-based memory into a III-V nanowire (NW) based optoelectronic neural node circuit designed for handling optical signals in a neural network. The new circuit can receive inhibiting and exciting light signals, store them, perform

Background Epithelial damage, repair and remodelling are critical features of chronic airway diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 released from damaged airway epithelia causes inflammation via its receptor, serum stimulation-2 (ST2). Oxidation of IL-33 to a non-ST2-binding form (IL-33ox) is thought to limit its activity. We investigated whether IL-33

Historians of the universities have not always belonged to the avantgarde of historical research. On the contrary, many studies of the universities have tended to be rather traditional and narrow-minded. In recent years, however, the surge in the history of knowledge has opened up novel perspectives and given new impulses to how to write the history of the universities. In this presentation, Johan

Sequencing batch reactors (SBRs) are devices widely used in wastewater treatment, chemical engineering, and other areas. They allow for the sedimentation and compression of solid particles of biomass simultaneously with biochemical reactions with nutrients dissolved in the liquid. The kinetics of these reactions may be given by one of the established activated sludge models (ASMx). An SBR is opera

The 113I nucleus has been studied using the 58Ni(58Ni,3p) reaction at 250 MeV with the Gammasphere/ Microball facility. Gamma-ray three-and four-fold data gated by charged particle combinations were analyzed. Multipolarities of the γ rays were assigned following the angular correlation measurements. The present study is focused on the high spin properties, where the structure is dominated by 2p-2h

This review summarizes the presentations made to a workshop entitled “Targeting Neurotrophin and Nitric Oxide Signaling to Promote Recovery and Ameliorate Neurogenic Bladder Dysfunction following Spinal Cord Injury – Mechanistic Concepts and Clinical Implications” at the International Continence Society (ICS) 2022 Vienna Meeting. Spinal cord injury (SCI; T8-T9 contusion/transection) causes impaire

Introduction Simulation-based studies indicate that crisis checklist use improves management of patients with critical conditions in the emergency department (ED). An interview-based study suggests that use of an emergency manual (EM) - a collection of crisis checklists - improves management of clinical perioperative crises. There is a need for in-depth prospective studies of EM use during clinica

BACKGROUND: Lumbar puncture is a common invasive procedure performed in newborns for diagnostic and therapeutic purposes. Approximately one in two lumbar punctures fail, resulting in both short- and long-term negative consequences for the clinical management of patients. The most common positions used to perform lumbar puncture are the lateral decubitus and sitting position, and each can impact th

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of acupuncture in newborn infants undergoing painful procedures.

Purpose: Reablement is a multidisciplinary intervention aimed at promoting function and independence for people with functional decline. Detailed descriptions of various professions’ actions are needed for organization and evaluation of reablement services. This study describes physiotherapy practice in a reablement context in Swedish municipalities, focusing on the content and magnitude of interv

Background: Epidemiological studies have shown an association between periodontitis and nonalcoholic fatty liver disease (NAFLD)-related diseases. However, a causal relationship between these two diseases remains unclear. To examine the causal relationship between these two diseases, we conducted a bidirectional two-sample Mendelian randomization (MR) analysis using genetic markers as proxies. Met